Intermittent parathyroid hormone (1-34) enhances mechanical strength and density of new bone after distraction osteogenesis in rats.

Seebach C, Skripitz R, Andreassen TT, Aspenberg P

Journal of orthopaedic research : official publication of the Orthopaedic Research Society1 May 2004Cited by 60 (Europe PMC)

PMID15099623DOI10.1016/j.orthres.2003.08.018PepBankPUB-15099623

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased ultimate load by 56% versus untreated distraction specimens after 20 days consolidation.
In plain wordsIn rats, PTH increased new bone breaking strength versus untreated specimens after 20 days consolidation.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseUltimate load at 20 days consolidation
Study
Rattus norvegicusn: not reported in source
Male Sprague-Dawley rats undergoing femoral distraction osteogenesis
Comparator
Untreated distraction osteogenesis specimens
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg every second day · 30 daysAs given in this study (Rattus norvegicus).
Measurements
Ultimate load increase
56%
20 days consolidation versus untreated
Source sentences
Summary
In the 20 days consolidation experiment, PTH(1-34) increased ultimate load (56%), stiffness (117%), total regenerate callus volume (58%), callus BMC (24%) and histologic bone density (35%) compared to untreated distraction osteogenesis specimens.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator.
Summary · context
A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed.
Report a problemFND-1509962301
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased stiffness by 117% versus untreated distraction specimens after 20 days consolidation.
In plain wordsIn rats, PTH increased new bone stiffness versus untreated specimens after 20 days consolidation.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseStiffness at 20 days consolidation
Study
Rattus norvegicusn: not reported in source
Male Sprague-Dawley rats undergoing femoral distraction osteogenesis
Comparator
Untreated distraction osteogenesis specimens
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg every second day · 30 daysAs given in this study (Rattus norvegicus).
Source sentences
Summary
In the 20 days consolidation experiment, PTH(1-34) increased ultimate load (56%), stiffness (117%), total regenerate callus volume (58%), callus BMC (24%) and histologic bone density (35%) compared to untreated distraction osteogenesis specimens.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator.
Summary · context
A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed.
Report a problemFND-1509962302
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased total regenerate callus volume by 58% versus untreated specimens after 20 days consolidation.
In plain wordsIn rats, PTH increased healing bone volume versus untreated specimens after 20 days consolidation.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseRegenerate callus volume at 20 days consolidation
Study
Rattus norvegicusn: not reported in source
Male Sprague-Dawley rats undergoing femoral distraction osteogenesis
Comparator
Untreated distraction osteogenesis specimens
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg every second day · 30 daysAs given in this study (Rattus norvegicus).
Source sentences
Summary
In the 20 days consolidation experiment, PTH(1-34) increased ultimate load (56%), stiffness (117%), total regenerate callus volume (58%), callus BMC (24%) and histologic bone density (35%) compared to untreated distraction osteogenesis specimens.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator.
Summary · context
A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed.
Report a problemFND-1509962303
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased callus bone mineral content by 24% versus untreated specimens after 20 days consolidation.
In plain wordsIn rats, PTH increased healing bone mineral content versus untreated specimens after 20 days consolidation.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus BMC at 20 days consolidation
Study
Rattus norvegicusn: not reported in source
Male Sprague-Dawley rats undergoing femoral distraction osteogenesis
Comparator
Untreated distraction osteogenesis specimens
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg every second day · 30 daysAs given in this study (Rattus norvegicus).
Source sentences
Summary
In the 20 days consolidation experiment, PTH(1-34) increased ultimate load (56%), stiffness (117%), total regenerate callus volume (58%), callus BMC (24%) and histologic bone density (35%) compared to untreated distraction osteogenesis specimens.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator.
Summary · context
A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed.
Report a problemFND-1509962304
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased histologic bone density by 35% versus untreated specimens after 20 days consolidation.
In plain wordsIn rats, PTH increased healing bone density versus untreated specimens after 20 days consolidation.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseHistologic bone density at 20 days consolidation
Study
Rattus norvegicusn: not reported in source
Male Sprague-Dawley rats undergoing femoral distraction osteogenesis
Comparator
Untreated distraction osteogenesis specimens
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg every second day · 30 daysAs given in this study (Rattus norvegicus).
Source sentences
Summary
In the 20 days consolidation experiment, PTH(1-34) increased ultimate load (56%), stiffness (117%), total regenerate callus volume (58%), callus BMC (24%) and histologic bone density (35%) compared to untreated distraction osteogenesis specimens.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator.
Summary · context
A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed.
Report a problemFND-1509962305
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased ultimate load by 54% versus untreated specimens after 40 days consolidation.
In plain wordsIn rats, PTH increased new bone breaking strength versus untreated specimens after 40 days consolidation.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseUltimate load at 40 days consolidation
Study
Rattus norvegicusn: not reported in source
Male Sprague-Dawley rats undergoing femoral distraction osteogenesis
Comparator
Untreated distraction osteogenesis specimens
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg every second day · 30 daysAs given in this study (Rattus norvegicus).
Source sentences
Summary
In the 40 days consolidation experiment, PTH(1-34) increased ultimate load (54%), stiffness (55%), callus BMC (33%) and histologic bone density (23%) compared to untreated distraction osteogenesis specimens.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator.
Summary · context
A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed.
Report a problemFND-1509962306
07AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased stiffness by 55% versus untreated specimens after 40 days consolidation.
In plain wordsIn rats, PTH increased new bone stiffness versus untreated specimens after 40 days consolidation.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseStiffness at 40 days consolidation
Study
Rattus norvegicusn: not reported in source
Male Sprague-Dawley rats undergoing femoral distraction osteogenesis
Comparator
Untreated distraction osteogenesis specimens
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg every second day · 30 daysAs given in this study (Rattus norvegicus).
Source sentences
Summary
In the 40 days consolidation experiment, PTH(1-34) increased ultimate load (54%), stiffness (55%), callus BMC (33%) and histologic bone density (23%) compared to untreated distraction osteogenesis specimens.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator.
Summary · context
A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed.
Report a problemFND-1509962307
08AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased callus bone mineral content by 33% versus untreated specimens after 40 days consolidation.
In plain wordsIn rats, PTH increased healing bone mineral content versus untreated specimens after 40 days consolidation.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus BMC at 40 days consolidation
Study
Rattus norvegicusn: not reported in source
Male Sprague-Dawley rats undergoing femoral distraction osteogenesis
Comparator
Untreated distraction osteogenesis specimens
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg every second day · 30 daysAs given in this study (Rattus norvegicus).
Source sentences
Summary
In the 40 days consolidation experiment, PTH(1-34) increased ultimate load (54%), stiffness (55%), callus BMC (33%) and histologic bone density (23%) compared to untreated distraction osteogenesis specimens.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator.
Summary · context
A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed.
Report a problemFND-1509962308
09AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH increased histologic bone density by 23% versus untreated specimens after 40 days consolidation.
In plain wordsIn rats, PTH increased healing bone density versus untreated specimens after 40 days consolidation.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseHistologic bone density at 40 days consolidation
Study
Rattus norvegicusn: not reported in source
Male Sprague-Dawley rats undergoing femoral distraction osteogenesis
Comparator
Untreated distraction osteogenesis specimens
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg every second day · 30 daysAs given in this study (Rattus norvegicus).
Source sentences
Summary
In the 40 days consolidation experiment, PTH(1-34) increased ultimate load (54%), stiffness (55%), callus BMC (33%) and histologic bone density (23%) compared to untreated distraction osteogenesis specimens.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator.
Summary · context
A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed.
Report a problemFND-1509962309
10AnimalAnimal study (in vivo)Efficacy outcome
In rats, total regenerate callus volume was unchanged with PTH versus untreated specimens after 40 days consolidation.
In plain wordsIn rats, PTH did not change healing bone volume versus untreated specimens after 40 days consolidation.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeRegenerate callus volume at 40 days consolidation
Study
Rattus norvegicusn: not reported in source
Male Sprague-Dawley rats undergoing femoral distraction osteogenesis
Comparator
Untreated distraction osteogenesis specimens
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg every second day · 30 daysAs given in this study (Rattus norvegicus).
Source sentences
Summary
Total regenerate callus volume was unchanged.
3 context sentences(design, population, supporting numbers)
Summary · context
In the 40 days consolidation experiment, PTH(1-34) increased ultimate load (54%), stiffness (55%), callus BMC (33%) and histologic bone density (23%) compared to untreated distraction osteogenesis specimens.
Summary · context
Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator.
Summary · context
A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed.
Report a problemFND-1509962310
11AnimalAnimal study (in vivo)Efficacy outcome
In rats, contralateral femora became stronger, stiffer and denser with PTH, but less than distracted femora.
In plain wordsIn rats, PTH also improved the opposite thigh bone's properties, but less than the lengthened bone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseContralateral femur properties
Study
Rattus norvegicusn: not reported in source
Male Sprague-Dawley rats undergoing femoral distraction osteogenesis
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 microg/kg every second day · 30 daysAs given in this study (Rattus norvegicus).
Source sentences
Summary
The contralateral femur also became stronger, stiffer and denser under PTH(1-34) treatment, but to a lesser degree.
2 context sentences(design, population, supporting numbers)
Summary · context
Forty-seven, 3-months-old male Sprague-Dawley rats underwent lengthening of the right femur using an external fixator.
Summary · context
A dose of 60 microg of human PTH(1-34)/kg body weight/injection or vehicle was given every second day beginning 30 days before the rats were killed.
Report a problemFND-1509962311

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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