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Study · In vitro (cells) · mouse · 2004

8 results

The modulation of thymosin alpha 1 in the maturation, differentiation and function of murine bone marrow-derived dendritic cells in the absence or presence of tumor necrosis factor-alpha.

Huang Y, Chen Z, Zhou C, Yao H, Li M, Xu C

International immunopharmacology1 Apr 2004Cited by 11 (Europe PMC)

PMID15099531 (opens in a new tab)DOI10.1016/j.intimp.2004.02.008 (opens in a new tab)PepBankPUB-15099531
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In murine bone marrow-derived dendritic cells without TNF-alpha, thymosin alpha‑1 promoted CD4-expressed DC differentiation.

    In plain wordsIn lab tests on mouse immune cells, thymosin alpha‑1 promoted dendritic cell differentiation.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD4-expressed DC differentiation without TNF-alpha
    Study

    mousen: not reported in source

    Murine bone marrow-derived dendritic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Talpha1 promoted CD4-expressed DC differentiation and the expression of activation markers, but did not influence IL-12 production and T cell-stimulatory capacity of DCs in the absence of TNFalpha during BMDCs maturation.
    1 context sentence
    Summary · context
    In this study, the effect of Talpha1 in vitro on murine bone marrow-derived DCs (BMDCs) maturation, differentiation, and function with or without tumor necrosis factor-alpha (TNF-alpha), which is one of the important inflammatory parameters, has been investigated.
  2. 02LabIn vitro (cells)Mechanism

    In murine dendritic cells without TNF-alpha, thymosin alpha‑1 promoted the expression of activation markers.

    In plain wordsIn lab tests on mouse immune cells, thymosin alpha‑1 raised activation markers on dendritic cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseActivation marker expression without TNF-alpha
    Study

    mousen: not reported in source

    Murine bone marrow-derived dendritic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We have shown, through flow cytometry, ELISA and mixed leukocyte reaction (MLR), that Talpha1 promoted CD4-expressed DC differentiation and the expression of activation markers, but did not influence IL-12 production and T cell-stimulatory capacity of DCs in the absence of TNFalpha during BMDCs maturation.
    1 context sentence
    Summary · context
    In this study, the effect of Talpha1 in vitro on murine bone marrow-derived DCs (BMDCs) maturation, differentiation, and function with or without tumor necrosis factor-alpha (TNF-alpha), which is one of the important inflammatory parameters, has been investigated.
  3. 03LabIn vitro (cells)Mechanism

    In murine dendritic cells without TNF-alpha, thymosin alpha‑1 did not influence IL-12 production.

    In plain wordsIn lab tests on mouse immune cells, thymosin alpha‑1 did not change IL-12 production.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeIL-12 production without TNF-alpha
    Study

    mousen: not reported in source

    Murine bone marrow-derived dendritic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We have shown, through flow cytometry, ELISA and mixed leukocyte reaction (MLR), that Talpha1 promoted CD4-expressed DC differentiation and the expression of activation markers, but did not influence IL-12 production and T cell-stimulatory capacity of DCs in the absence of TNFalpha during BMDCs maturation.
    1 context sentence
    Summary · context
    In this study, the effect of Talpha1 in vitro on murine bone marrow-derived DCs (BMDCs) maturation, differentiation, and function with or without tumor necrosis factor-alpha (TNF-alpha), which is one of the important inflammatory parameters, has been investigated.
  4. 04LabIn vitro (cells)Mechanism

    In murine dendritic cells without TNF-alpha, thymosin alpha‑1 did not influence T cell-stimulatory capacity.

    In plain wordsIn lab tests on mouse immune cells, thymosin alpha‑1 did not change how strongly the cells stimulated T cells.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeT cell-stimulatory capacity of DCs without TNF-alpha
    Study

    mousen: not reported in source

    Murine bone marrow-derived dendritic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We have shown, through flow cytometry, ELISA and mixed leukocyte reaction (MLR), that Talpha1 promoted CD4-expressed DC differentiation and the expression of activation markers, but did not influence IL-12 production and T cell-stimulatory capacity of DCs in the absence of TNFalpha during BMDCs maturation.
    1 context sentence
    Summary · context
    In this study, the effect of Talpha1 in vitro on murine bone marrow-derived DCs (BMDCs) maturation, differentiation, and function with or without tumor necrosis factor-alpha (TNF-alpha), which is one of the important inflammatory parameters, has been investigated.
  5. 05LabIn vitro (cells)Mechanism

    In murine dendritic cells exposed to TNF-alpha, thymosin alpha‑1 promoted CD4 expression on MHC class II+ DCs.

    In plain wordsIn lab tests on mouse immune cells exposed to TNF-alpha, thymosin alpha‑1 raised CD4 on dendritic cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD4 expression on MHC class II+ DCs with TNF-alpha
    Study

    mousen: not reported in source

    Murine bone marrow-derived dendritic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, in the presence of TNF-alpha, Talpha1 has been shown not only to promote the expression of CD4 on MHC class II+ DCs and enhance the up-regulated levels of mature markers induced by TNF-alpha, but also to suppress the up-regulated IL-12 production.
    1 context sentence
    Summary · context
    In this study, the effect of Talpha1 in vitro on murine bone marrow-derived DCs (BMDCs) maturation, differentiation, and function with or without tumor necrosis factor-alpha (TNF-alpha), which is one of the important inflammatory parameters, has been investigated.
  6. 06LabIn vitro (cells)Mechanism

    In murine dendritic cells exposed to TNF-alpha, thymosin alpha‑1 enhanced the up-regulated levels of mature markers induced by TNF-alpha.

    In plain wordsIn lab tests on mouse immune cells, thymosin alpha‑1 further raised maturation markers that TNF-alpha had increased.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseMature marker levels induced by TNF-alpha
    Study

    mousen: not reported in source

    Murine bone marrow-derived dendritic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, in the presence of TNF-alpha, Talpha1 has been shown not only to promote the expression of CD4 on MHC class II+ DCs and enhance the up-regulated levels of mature markers induced by TNF-alpha, but also to suppress the up-regulated IL-12 production.
    1 context sentence
    Summary · context
    In this study, the effect of Talpha1 in vitro on murine bone marrow-derived DCs (BMDCs) maturation, differentiation, and function with or without tumor necrosis factor-alpha (TNF-alpha), which is one of the important inflammatory parameters, has been investigated.
  7. 07LabIn vitro (cells)Mechanism

    In murine dendritic cells exposed to TNF-alpha, thymosin alpha‑1 suppressed the up-regulated IL-12 production.

    In plain wordsIn lab tests on mouse immune cells, thymosin alpha‑1 lowered the IL-12 production that TNF-alpha had raised.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseIL-12 production with TNF-alpha
    Study

    mousen: not reported in source

    Murine bone marrow-derived dendritic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, in the presence of TNF-alpha, Talpha1 has been shown not only to promote the expression of CD4 on MHC class II+ DCs and enhance the up-regulated levels of mature markers induced by TNF-alpha, but also to suppress the up-regulated IL-12 production.
    1 context sentence
    Summary · context
    In this study, the effect of Talpha1 in vitro on murine bone marrow-derived DCs (BMDCs) maturation, differentiation, and function with or without tumor necrosis factor-alpha (TNF-alpha), which is one of the important inflammatory parameters, has been investigated.
  8. 08LabIn vitro (cells)Mechanism

    Thymosin alpha‑1 did not inhibit the TNF-alpha-induced T-cell stimulating function of murine dendritic cells.

    In plain wordsIn lab tests on mouse immune cells, thymosin alpha‑1 did not reduce the cells' ability to stimulate T cells.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeTNF-alpha-induced T-cell stimulating function of DCs
    Study

    mousen: not reported in source

    Murine bone marrow-derived dendritic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, Talpha1 did not inhibit TNF-alpha-induced T-cell stimulating function of DCs.
    1 context sentence
    Summary · context
    In this study, the effect of Talpha1 in vitro on murine bone marrow-derived DCs (BMDCs) maturation, differentiation, and function with or without tumor necrosis factor-alpha (TNF-alpha), which is one of the important inflammatory parameters, has been investigated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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