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Study · Not a test of the peptide alone · 2004

1 result

Fibroblast growth factor-2 over-rides insulin-like growth factor-I induced proliferation and cell survival in human neuroblastoma cells.

Russo VC, Andaloro E, Fornaro SA, Najdovska S, Newgreen DF, Bach LA, Werther GA

Journal of cellular physiology1 Jun 2004Cited by 20 (Europe PMC)

PMID15095284 (opens in a new tab)DOI10.1002/jcp.10416 (opens in a new tab)PepBankPUB-15095284
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 01LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism

    In SK-N-MC cells, des(1‑3)IGF-I could not overcome FGF-2 inhibition of cell proliferation.

    In plain wordsIn cells, des(1‑3)IGF-I did not overcome FGF-2 inhibition of neuroblastoma cell growth.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeReversal of FGF-2 inhibition of proliferation
    Study

    humann: not reported in source

    SK-N-MC neuroblastoma cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Modulation of IGFBP-2 and -6 levels were not significant mechanisms involved in the blockade of IGF-I action since the potent IGF-I analogues [QAYL]IGF-I and des(1-3)IGF-I (minimal IGFBP affinity) were unable to overcome FGF-2 inhibition of cell proliferation.
    1 context sentence
    Summary · context
    To investigate IGF/FGF interactions in neuronal cells, we employed neuroblastoma cells (SK-N-MC).

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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