The effect of oxytocin on cortisol and corticosterone secretion in cyclic gilts--in vivo and in vitro studies.

Kotwica G, Kamińska B, Franczak A, Kurowicka B, Staszkiewicz J, Skowroński MT, Kraziński B, Okrasa S

Reproductive biology1 Mar 2004Cited by 11 (Europe PMC)

PMID15094794PepBankPUB-15094794

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In luteal-phase gilts, oxytocin injections increased plasma cortisol.
In plain wordsIn pigs in the luteal phase, oxytocin injections raised blood cortisol.
Peptide
Oxytocin
Outcome
IncreasePlasma cortisol after OT injection, luteal phase
Study
pign = 5
Cyclic gilts, in vivo
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated · injectionAs given in this study (pig).
Source sentences
Summary
In the luteal-phase gilts (n=5), OT injections increased both cortisol (p<0.01) and corticosterone (p<0.05) plasma concentrations, but in the follicular-phase gilts (n=5) only the concentration of cortisol (p<0.05) was elevated in response to the treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study changes in plasma cortisol and corticosterone concentrations in response to exogenous OT (in vivo experiment) and a direct influence of OT on adrenocortical steroidogenesis (in vitro experiment) were determined in luteal- and follicular-phase gilts.
Report a problemFND-1509479401
02AnimalAnimal study (in vivo)Efficacy outcome
In luteal-phase gilts, oxytocin injections increased plasma corticosterone.
In plain wordsIn pigs in the luteal phase, oxytocin injections raised blood corticosterone.
Peptide
Oxytocin
Outcome
IncreasePlasma corticosterone after OT injection, luteal phase
Study
pign = 5
Cyclic gilts, in vivo
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated · injectionAs given in this study (pig).
Source sentences
Summary
In the luteal-phase gilts (n=5), OT injections increased both cortisol (p<0.01) and corticosterone (p<0.05) plasma concentrations, but in the follicular-phase gilts (n=5) only the concentration of cortisol (p<0.05) was elevated in response to the treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study changes in plasma cortisol and corticosterone concentrations in response to exogenous OT (in vivo experiment) and a direct influence of OT on adrenocortical steroidogenesis (in vitro experiment) were determined in luteal- and follicular-phase gilts.
Report a problemFND-1509479402
03AnimalAnimal study (in vivo)Efficacy outcome
In follicular-phase gilts, oxytocin injections increased plasma cortisol.
In plain wordsIn pigs in the follicular phase, oxytocin injections raised blood cortisol.
Peptide
Oxytocin
Outcome
IncreasePlasma cortisol after OT injection, follicular phase
Study
pign = 5
Cyclic gilts, in vivo
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated · injectionAs given in this study (pig).
Source sentences
Summary
In the luteal-phase gilts (n=5), OT injections increased both cortisol (p<0.01) and corticosterone (p<0.05) plasma concentrations, but in the follicular-phase gilts (n=5) only the concentration of cortisol (p<0.05) was elevated in response to the treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study changes in plasma cortisol and corticosterone concentrations in response to exogenous OT (in vivo experiment) and a direct influence of OT on adrenocortical steroidogenesis (in vitro experiment) were determined in luteal- and follicular-phase gilts.
Report a problemFND-1509479403
04AnimalAnimal study (in vivo)Efficacy outcome
In follicular-phase gilts, oxytocin injections did not raise plasma corticosterone.
In plain wordsIn pigs in the follicular phase, oxytocin injections did not raise blood corticosterone.
Peptide
Oxytocin
Outcome
No significant changePlasma corticosterone after OT injection, follicular phase
Study
pign = 5
Cyclic gilts, in vivo
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated · injectionAs given in this study (pig).
Source sentences
Summary
In the luteal-phase gilts (n=5), OT injections increased both cortisol (p<0.01) and corticosterone (p<0.05) plasma concentrations, but in the follicular-phase gilts (n=5) only the concentration of cortisol (p<0.05) was elevated in response to the treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study changes in plasma cortisol and corticosterone concentrations in response to exogenous OT (in vivo experiment) and a direct influence of OT on adrenocortical steroidogenesis (in vitro experiment) were determined in luteal- and follicular-phase gilts.
Report a problemFND-1509479404
05AnimalAnimal study (in vivo)Efficacy outcome
In gilts, the cortisol area under the curve after oxytocin injection was higher in the luteal than in the follicular phase.
In plain wordsIn pigs, oxytocin raised cortisol more in the luteal phase than in the follicular phase.
Peptide
Oxytocin
Outcome
IncreaseCortisol area under the curve after OT injection, luteal versus follicular
Study
pign: not reported in source
Cyclic gilts, in vivo
Comparator
Follicular-phase gilts
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated · injectionAs given in this study (pig).
Source sentences
Summary
Areas under the cortisol and corticosterone curves calculated for 30 min period after the OT injection were statistically higher (p<0.05) during the luteal than the follicular phase.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study changes in plasma cortisol and corticosterone concentrations in response to exogenous OT (in vivo experiment) and a direct influence of OT on adrenocortical steroidogenesis (in vitro experiment) were determined in luteal- and follicular-phase gilts.
Report a problemFND-1509479405
06AnimalAnimal study (in vivo)Efficacy outcome
In gilts, the corticosterone area under the curve after oxytocin injection was higher in the luteal than in the follicular phase.
In plain wordsIn pigs, oxytocin raised corticosterone more in the luteal phase than in the follicular phase.
Peptide
Oxytocin
Outcome
IncreaseCorticosterone area under the curve after OT injection, luteal versus follicular
Study
pign: not reported in source
Cyclic gilts, in vivo
Comparator
Follicular-phase gilts
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated · injectionAs given in this study (pig).
Source sentences
Summary
Areas under the cortisol and corticosterone curves calculated for 30 min period after the OT injection were statistically higher (p<0.05) during the luteal than the follicular phase.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study changes in plasma cortisol and corticosterone concentrations in response to exogenous OT (in vivo experiment) and a direct influence of OT on adrenocortical steroidogenesis (in vitro experiment) were determined in luteal- and follicular-phase gilts.
Report a problemFND-1509479406
07LabIn vitro (cells)Efficacy outcome
In porcine adrenocortical cells from the luteal phase, oxytocin at two doses increased cortisol secretion.
In plain wordsIn pig adrenal cells grown in a dish, oxytocin raised cortisol release in cells from the luteal phase.
Peptide
Oxytocin
Outcome
IncreaseCortisol secretion by luteal-phase adrenocortical cells
Study
pign: not reported in source
Porcine adrenocortical cells
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
10(-7) and 10(-6) MAs given in this study (pig).
Source sentences
Summary
In the in vitro experiment, two doses of OT (10(-7) and 10(-6) M) increased (p<0.05) secretion of cortisol by porcine adrenocortical cells representing the luteal phase, but not the follicular phase.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study changes in plasma cortisol and corticosterone concentrations in response to exogenous OT (in vivo experiment) and a direct influence of OT on adrenocortical steroidogenesis (in vitro experiment) were determined in luteal- and follicular-phase gilts.
Report a problemFND-1509479407
08LabIn vitro (cells)Efficacy outcome
In porcine adrenocortical cells from the follicular phase, oxytocin did not increase cortisol secretion.
In plain wordsIn pig adrenal cells grown in a dish, oxytocin did not raise cortisol release in cells from the follicular phase.
Peptide
Oxytocin
Outcome
No significant changeCortisol secretion by follicular-phase adrenocortical cells
Study
pign: not reported in source
Porcine adrenocortical cells
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
10(-7) and 10(-6) MAs given in this study (pig).
Source sentences
Summary
In the in vitro experiment, two doses of OT (10(-7) and 10(-6) M) increased (p<0.05) secretion of cortisol by porcine adrenocortical cells representing the luteal phase, but not the follicular phase.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study changes in plasma cortisol and corticosterone concentrations in response to exogenous OT (in vivo experiment) and a direct influence of OT on adrenocortical steroidogenesis (in vitro experiment) were determined in luteal- and follicular-phase gilts.
Report a problemFND-1509479408
09LabIn vitro (cells)Efficacy outcome
In porcine adrenocortical cells, oxytocin did not affect corticosterone release.
In plain wordsIn pig adrenal cells grown in a dish, oxytocin did not change corticosterone release.
Peptide
Oxytocin
Outcome
No significant changeCorticosterone release by adrenocortical cells
Study
pign: not reported in source
Porcine adrenocortical cells
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
However, OT did not affect the release of corticosterone by the cells.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study changes in plasma cortisol and corticosterone concentrations in response to exogenous OT (in vivo experiment) and a direct influence of OT on adrenocortical steroidogenesis (in vitro experiment) were determined in luteal- and follicular-phase gilts.
Report a problemFND-1509479409

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

10LabNot a test of Oxytocin aloneIn vitro (cells)Efficacy outcome
In porcine adrenocortical cells, incubation with an oxytocin antagonist abolished the effect of oxytocin on cortisol secretion; the result describes the antagonist.
In plain wordsIn pig adrenal cells grown in a dish, an oxytocin blocker removed the cortisol rise caused by oxytocin.
Peptide
Oxytocin
Outcome
DecreaseCortisol secretion with an oxytocin antagonist
Study
pign: not reported in source
Porcine adrenocortical cells
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
Incubation of the cells with the OT-antagonist (10(-5) M) abolished the effects of OT on cortisol secretion.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study changes in plasma cortisol and corticosterone concentrations in response to exogenous OT (in vivo experiment) and a direct influence of OT on adrenocortical steroidogenesis (in vitro experiment) were determined in luteal- and follicular-phase gilts.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1509479410

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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