Effects of short peptides on lymphocyte chromatin in senile subjects.

Khavinson VKh, Lezhava TA, Malinin VV

Bulletin of experimental biology and medicine1 Jan 2004Cited by 2 (Europe PMC)

PMID15085253DOI10.1023/b:bebm.0000024393.40560.05PepBankPUB-15085253

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In leukocytes of elderly subjects, treatment with epithalon led to decondensation of chromosome 1 pericentromeric structural chromatin.
In plain wordsIn cells from elderly donors, epithalon loosened the packed chromatin near the centre of chromosome 1.
Peptide
Epitalon
Outcome
DecreaseChromosome 1 pericentromeric chromatin condensation
Study
humann: not reported in source
leukocytes from subjects aged 75-88 years
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
Treatment with Epithalon, Livagen, and Prostamax led to decondensation of chromosome 1 pericentromeric structural chromatin
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic short peptides (Vilon, Epithalon, Livagen, Prostamax, and Cortagen) on activity of ribosome genes, parameters of common heterochromatin melting, polymorphism of structural heterochromatin (C segments) of chromosomes 1, 9, and 16, and variability of facultative heterochromatin we…
Report a problemFND-1508525304
02LabIn vitro (cells)Mechanism
In leukocytes of elderly subjects, epithalon treatment led to changes in chromosome 9; the direction is not stated.
In plain wordsIn cells from elderly donors, epithalon changed chromosome 9. The abstract does not say in which direction.
Peptide
Epitalon
Outcome
Direction not reportedChromosome 9 chromatin changes
Study
humann: not reported in source
leukocytes from subjects aged 75-88 years
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
while Epithalon and Livagen treatment led to changes in chromosome 9 as well.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic short peptides (Vilon, Epithalon, Livagen, Prostamax, and Cortagen) on activity of ribosome genes, parameters of common heterochromatin melting, polymorphism of structural heterochromatin (C segments) of chromosomes 1, 9, and 16, and variability of facultative heterochromatin we…
Report a problemFND-1508525305
03LabIn vitro (cells)Mechanism
In leukocytes from senile subjects, Livagen induced chromosome 1 pericentromeric structural chromatin decondensation.
In plain wordsIn cells from old donors, Livagen induced chromosome 1 pericentromeric structural chromatin decondensation.
Peptide
Livagen (KEDA)
Outcome
IncreaseChromosome 1 pericentromeric structural chromatin decondensation
Study
humann: not reported in source
Leukocytes from subjects aged 75-88 years
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
Treatment with Epithalon, Livagen, and Prostamax led to decondensation of chromosome 1 pericentromeric structural chromatin, while Epithalon and Livagen treatment led to changes in chromosome 9 as well.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic short peptides (Vilon, Epithalon, Livagen, Prostamax, and Cortagen) on activity of ribosome genes, parameters of common heterochromatin melting, polymorphism of structural heterochromatin (C segments) of chromosomes 1, 9, and 16, and variability of facultative heterochromatin we…
Report a problemFND-1508525306
04LabIn vitro (cells)Mechanism
In leukocytes from senile subjects, Livagen induced changes in chromosome 9 structural chromatin.
In plain wordsIn cells from old donors, Livagen induced changes in chromosome 9 structural chromatin.
Peptide
Livagen (KEDA)
Outcome
Direction not reportedChromosome 9 structural chromatin changes
Study
humann: not reported in source
Leukocytes from subjects aged 75-88 years
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
Treatment with Epithalon, Livagen, and Prostamax led to decondensation of chromosome 1 pericentromeric structural chromatin, while Epithalon and Livagen treatment led to changes in chromosome 9 as well.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic short peptides (Vilon, Epithalon, Livagen, Prostamax, and Cortagen) on activity of ribosome genes, parameters of common heterochromatin melting, polymorphism of structural heterochromatin (C segments) of chromosomes 1, 9, and 16, and variability of facultative heterochromatin we…
Report a problemFND-1508525307
05LabIn vitro (cells)Mechanism
In leukocytes from older subjects, Prostamax induced decondensation of chromosome 1 pericentromeric structural chromatin.
In plain wordsIn lab tests with older subjects' leukocytes, Prostamax loosened structural chromatin near the chromosome 1 centromere.
Peptide
Prostamax (KEDP)
Outcome
IncreaseChromosome 1 pericentromeric structural chromatin decondensation
Study
humann: not reported in source
Leukocytes from subjects aged 75-88 years
Outcome group
Receptor activity and mechanism · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
Treatment with Epithalon, Livagen, and Prostamax led to decondensation of chromosome 1 pericentromeric structural chromatin
2 context sentences(design, population, supporting numbers)
Summary · context
Effects of synthetic short peptides (Vilon, Epithalon, Livagen, Prostamax, and Cortagen)
Summary · context
were studied in leukocytes of subjects aged 75-88 years.
Report a problemFND-1508525308

Studies that did not test the peptide alone3

In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Epitalon.

06LabNot a test of Epitalon aloneIn vitro (cells)Mechanism
In leukocytes of elderly subjects, the five short peptides tested (Vilon, Epithalon, Livagen, Prostamax, Cortagen) pooled together activated ribosome genes.
In plain wordsIn cells from elderly donors, the five short peptides together switched on ribosome genes. This result is not for epithalon alone.
Peptide
Epitalon
Outcome
IncreaseRibosome gene activity
Study
humann: not reported in source
leukocytes from subjects aged 75-88 years
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
All the studied peptides induced activation of ribosome genes
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic short peptides (Vilon, Epithalon, Livagen, Prostamax, and Cortagen) on activity of ribosome genes, parameters of common heterochromatin melting, polymorphism of structural heterochromatin (C segments) of chromosomes 1, 9, and 16, and variability of facultative heterochromatin we…
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-1508525301
07LabNot a test of Epitalon aloneIn vitro (cells)Mechanism
In leukocytes of elderly subjects, the five short peptides tested pooled together decondensed densely packed chromatin fibrils.
In plain wordsIn cells from elderly donors, the five short peptides together loosened tightly packed chromatin. This result is not for epithalon alone.
Peptide
Epitalon
Outcome
DecreaseChromatin fibril condensation
Study
humann: not reported in source
leukocytes from subjects aged 75-88 years
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
All the studied peptides induced activation of ribosome genes, decondensation of densely packed chromatin fibrils
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic short peptides (Vilon, Epithalon, Livagen, Prostamax, and Cortagen) on activity of ribosome genes, parameters of common heterochromatin melting, polymorphism of structural heterochromatin (C segments) of chromosomes 1, 9, and 16, and variability of facultative heterochromatin we…
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-1508525302
08LabNot a test of Epitalon aloneIn vitro (cells)Mechanism
In leukocytes of elderly subjects, the five short peptides tested pooled together released genes repressed by age-specific condensation of euchromatin.
In plain wordsIn cells from elderly donors, the five short peptides together released genes that age had switched off. This result is not for epithalon alone.
Peptide
Epitalon
Outcome
IncreaseRelease of repressed genes (deheterochromatinization)
Study
humann: not reported in source
leukocytes from subjects aged 75-88 years
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
All the studied peptides induced activation of ribosome genes, decondensation of densely packed chromatin fibrils, and release of genes repressed as a result of age-specific condensation of the cellular euchromatin regions (deheterochromatinization of facultative chromatin).
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic short peptides (Vilon, Epithalon, Livagen, Prostamax, and Cortagen) on activity of ribosome genes, parameters of common heterochromatin melting, polymorphism of structural heterochromatin (C segments) of chromosomes 1, 9, and 16, and variability of facultative heterochromatin we…
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-1508525303

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 6 to 12Current
28 Oct 2026, 02:02 UTC
The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.
Study results updated
Versions 3 to 5
21 Oct 2026, 16:35 UTC
The same notice was added 3 times, first on 21 Oct 2026, 16:35 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 2
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Effects of short peptides on lymphocyte chromatin in senile subjects.

Summary

Results from this study8

Studies that did not test the peptide alone3

Version history

Subjects

Publication types

MeSH terms