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Study · Other design · 2004

9 results

[Interspecies differences of noopept pharmacokinetics].

Boĭko SS, Korotkov SA, Zherdev VP, Gudasheva TA, Ostrovskaia RU, Voronina TA

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2004Cited by 2 (Europe PMC)

PMID15079908 (opens in a new tab)PepBankPUB-15079908
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 3 results from people.

  1. 01HumanOther designPharmacokinetics

    In humans, noopept elimination was slower than in rats and rabbits.

    In plain wordsNoopept left the human body more slowly than it left rats and rabbits.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseInterspecies elimination rate
    Study

    n: not reported in source

    Comparator
    Rats and rabbits
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The noopept pharmacokinetics in humans differs from that in animals by still slower elimination and considerable individual variability.
    1 context sentence
    Summary · context
    Significant interspecific differences in the pharmacokinetics of noopept are manifested by a decrease in the drug elimination rate on the passage from rats to rabbits and humans.
  2. 02HumanOther designPharmacokinetics

    In humans, noopept pharmacokinetics showed considerable individual variability.

    In plain wordsNoopept processing varied considerably between people.

    Peptide
    Noopept (omberacetam)
    Outcome
    Direction not reportedIndividual pharmacokinetic variability
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The noopept pharmacokinetics in humans differs from that in animals by still slower elimination and considerable individual variability.
  3. 03HumanOther designPharmacokinetics

    In humans, no noopept metabolites were found in blood plasma.

    In plain wordsTests found no noopept metabolites in human blood plasma.

    Peptide
    Noopept (omberacetam)
    Outcome
    Direction not reportedPlasma metabolites
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No drug metabolites are found in the human blood plasma, probably because of a relatively small dose and low concentration.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, noopept elimination was slower than in rats.

    In plain wordsIn rabbits, noopept left the body more slowly than in rats.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseInterspecies elimination rate
    Study

    rat and rabbitn: not reported in source

    Comparator
    Rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Significant interspecific differences in the pharmacokinetics of noopept are manifested by a decrease in the drug elimination rate on the passage from rats to rabbits and humans.
  5. 05AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, intravenously administered noopept underwent very intensive metabolism.

    In plain wordsIn rats, noopept underwent very intensive metabolism after intravenous administration.

    Peptide
    Noopept (omberacetam)
    Outcome
    Direction not reportedMetabolism
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Very intensive metabolism of noopept was observed upon intravenous administration in rats.
  6. 06AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, presystemic noopept elimination formed a metabolite hydroxylated at the phenyl ring.

    In plain wordsIn rats, noopept breakdown before systemic circulation formed a metabolite with a hydroxylated phenyl ring.

    Peptide
    Noopept (omberacetam)
    Outcome
    Not applicablePhenyl-ring hydroxylated metabolite formation
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In these animals, presystemic elimination mechanisms lead to the formation of a specific metabolite representing a product of drug biotransformation hydroxylated at the phenyl ring.
  7. 07AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, unchanged noopept circulated longer than in rats after intravenous and oral administration.

    In plain wordsIn rabbits, unchanged noopept remained in blood longer than in rats after intravenous and oral administration.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseUnchanged drug circulation time
    Study

    rabbitn: not reported in source

    Comparator
    Rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenous and oralAs given in this study (rabbit).

    Source sentences

    Summary
    In rabbits, unchanged noopept circulates in the blood for a longer time upon both intravenous and peroral introduction, biotransformation proceeds at a much slower rate, and no metabolites analogous to that found in rats are detected.
  8. 08AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, noopept biotransformation proceeded much more slowly than in rats.

    In plain wordsIn rabbits, noopept changed into other substances more slowly than in rats.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseBiotransformation rate
    Study

    rabbitn: not reported in source

    Comparator
    Rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenous and oralAs given in this study (rabbit).

    Source sentences

    Summary
    In rabbits, unchanged noopept circulates in the blood for a longer time upon both intravenous and peroral introduction, biotransformation proceeds at a much slower rate, and no metabolites analogous to that found in rats are detected.
  9. 09AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, noopept metabolites analogous to the rat metabolite were not detected.

    In plain wordsIn rabbits, tests detected no noopept metabolites similar to the rat metabolite.

    Peptide
    Noopept (omberacetam)
    Outcome
    Direction not reportedRat-analogous metabolites
    Study

    rabbitn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenous and oralAs given in this study (rabbit).

    Source sentences

    Summary
    In rabbits, unchanged noopept circulates in the blood for a longer time upon both intravenous and peroral introduction, biotransformation proceeds at a much slower rate, and no metabolites analogous to that found in rats are detected.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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