Skip to content

Study · In vitro (cells) · 2004

4 results

Identification and functional characterization of two alternatively spliced growth hormone secretagogue receptor transcripts from the pituitary of black seabream Acanthopagrus schlegeli.

Chan CB, Cheng CH

Molecular and cellular endocrinology1 Feb 2004Cited by 111 (Europe PMC)

PMID15062547 (opens in a new tab)DOI10.1016/j.mce.2003.11.020 (opens in a new tab)PepBankPUB-15062547
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In HEK293 cells expressing sbGHSR-1a, GHRP‑6 triggered an increase in intracellular calcium.

    In plain wordsIn lab tests, GHRP‑6 increased calcium inside cells with the seabream sbGHSR-1a receptor.

    Peptide
    GHRP-6
    Outcome
    IncreaseIntracellular calcium through sbGHSR-1a
    Study

    n: not reported in source

    HEK293 cells expressing seabream sbGHSR-1a
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A variety of structurally diverse growth hormone secretogogues (GHS), including the peptide GHS (GHRP-6 and ghrelin), the benzolactam GHS (L692,585) and the spiropiperidine GHS (L163,255), were able to trigger an elevation of intracellular Ca(2+) ion concentration in HEK293 cells expressing sbGHSR-1…
  2. 02LabIn vitro (cells)Mechanism

    In HEK293 cells expressing sbGHSR-1b, GHRP‑6 did not trigger an intracellular calcium increase.

    In plain wordsIn lab tests, GHRP‑6 did not increase calcium inside cells with the seabream sbGHSR-1b receptor.

    Peptide
    GHRP-6
    Outcome
    No significant changeIntracellular calcium through sbGHSR-1b
    Study

    n: not reported in source

    HEK293 cells expressing seabream sbGHSR-1b
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A variety of structurally diverse growth hormone secretogogues (GHS), including the peptide GHS (GHRP-6 and ghrelin), the benzolactam GHS (L692,585) and the spiropiperidine GHS (L163,255), were able to trigger an elevation of intracellular Ca(2+) ion concentration in HEK293 cells expressing sbGHSR-1…
  3. 03LabIn vitro (cells)Mechanism

    In CHO cells expressing sbGHSR-1a, GHRP‑6 increased extracellular acidification rate.

    In plain wordsIn lab tests, GHRP‑6 increased acidification outside cells with the seabream sbGHSR-1a receptor.

    Peptide
    GHRP-6
    Outcome
    IncreaseExtracellular acidification through sbGHSR-1a
    Study

    n: not reported in source

    CHO cells expressing seabream sbGHSR-1a
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Microphysiometry revealed that an increase in extracellular acidification rate (EAR) could be detected in CHO cells expressing the sbGHSR-1a receptor when stimulated with GHRP-6.
  4. 04LabIn vitro (cells)Mechanism

    In CHO cells expressing sbGHSR-1b, GHRP‑6 produced no detectable extracellular acidification rate change.

    In plain wordsIn lab tests, GHRP‑6 did not change acidification outside cells with the seabream sbGHSR-1b receptor.

    Peptide
    GHRP-6
    Outcome
    No significant changeExtracellular acidification through sbGHSR-1b
    Study

    n: not reported in source

    CHO cells expressing seabream sbGHSR-1b
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the contrary, CHO cells expressing the sbGHSR-1b receptor registered no detectable EAR changes.
    1 context sentence
    Summary · context
    Microphysiometry revealed that an increase in extracellular acidification rate (EAR) could be detected in CHO cells expressing the sbGHSR-1a receptor when stimulated with GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.