Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats.

Mollet A, Gilg S, Riediger T, Lutz TA

Physiology & behavior1 Mar 2004Cited by 106 (Europe PMC)

PMID15059694DOI10.1016/j.physbeh.2004.01.006PepBankPUB-15059694

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, salmon calcitonin infused into the area postrema inhibited food intake for about 2 h after food presentation.
In plain wordsIn rats, salmon calcitonin infused into the area postrema reduced food intake for about two hours.
Peptide
Calcitonin-salmon
Outcome
DecreaseFood intake
Study
ratn: not reported in source
rats with area postrema cannulas
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · infusion into area postremaAs given in this study (rat).
Source sentences
Summary
Amylin and sCT inhibited food intake for about 2 h after food presentation, mainly by reducing meal size when infused into the AP [e.g., 1 h food intake after amylin (0.4 microg/rat) infusion in 12-h deprived rats: NaCl 4.0+/-0.5 vs. amylin 2.4+/-0.5, P<.05].
1 context sentence(design, population, supporting numbers)
Summary · context
Rats with chronic cannulas aiming at the AP were infused with various doses of amylin, its agonist salmon calcitonin (sCT) or a cyclic guanosine monophosphate (cGMP) analogue.
Report a problemFND-1505969401
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, salmon calcitonin infused into the area postrema reduced meal size.
In plain wordsIn rats, salmon calcitonin infused into the area postrema reduced meal size.
Peptide
Calcitonin-salmon
Outcome
DecreaseMeal size
Study
ratn: not reported in source
rats with area postrema cannulas
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · infusion into area postremaAs given in this study (rat).
Source sentences
Summary
Amylin and sCT inhibited food intake for about 2 h after food presentation, mainly by reducing meal size when infused into the AP [e.g., 1 h food intake after amylin (0.4 microg/rat) infusion in 12-h deprived rats: NaCl 4.0+/-0.5 vs. amylin 2.4+/-0.5, P<.05].
1 context sentence(design, population, supporting numbers)
Summary · context
Rats with chronic cannulas aiming at the AP were infused with various doses of amylin, its agonist salmon calcitonin (sCT) or a cyclic guanosine monophosphate (cGMP) analogue.
Report a problemFND-1505969402
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, salmon calcitonin's feeding inhibition was comparable in ad libitum fed and 12-h food-deprived animals.
In plain wordsIn rats, salmon calcitonin reduced feeding similarly in freely fed and food-deprived animals.
Peptide
Calcitonin-salmon
Outcome
Direction not reportedFeeding inhibition by feeding state
Study
ratn: not reported in source
rats with area postrema cannulas
Comparator
Ad libitum fed versus food-deprived rats
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · infusion into area postremaAs given in this study (rat).
Source sentences
Summary
The effect was comparable in ad libitum fed and 12-h food-deprived rats with a minimal effective dose of 0.04 microg/rat.
2 context sentences(design, population, supporting numbers)
Summary · context
Amylin and sCT inhibited food intake for about 2 h after food presentation, mainly by reducing meal size when infused into the AP [e.g., 1 h food intake after amylin (0.4 microg/rat) infusion in 12-h deprived rats: NaCl 4.0+/-0.5 vs. amylin 2.4+/-0.5, P<.05].
Summary · context
Rats with chronic cannulas aiming at the AP were infused with various doses of amylin, its agonist salmon calcitonin (sCT) or a cyclic guanosine monophosphate (cGMP) analogue.
Report a problemFND-1505969403
04AnimalAnimal study (in vivo)Activity measurement
In rats, the reported minimal effective dose for feeding inhibition was 0.04 microg/rat.
In plain wordsIn rats, the reported minimal effective dose for feeding inhibition was 0.04 microg/rat.
Peptide
Calcitonin-salmon
Outcome
Not applicableMinimal effective dose
Study
ratn: not reported in source
rats with area postrema cannulas
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
0.04 microg/rat · infusion into area postremaAs given in this study (rat).
Source sentences
Summary
The effect was comparable in ad libitum fed and 12-h food-deprived rats with a minimal effective dose of 0.04 microg/rat.
2 context sentences(design, population, supporting numbers)
Summary · context
Amylin and sCT inhibited food intake for about 2 h after food presentation, mainly by reducing meal size when infused into the AP [e.g., 1 h food intake after amylin (0.4 microg/rat) infusion in 12-h deprived rats: NaCl 4.0+/-0.5 vs. amylin 2.4+/-0.5, P<.05].
Summary · context
Rats with chronic cannulas aiming at the AP were infused with various doses of amylin, its agonist salmon calcitonin (sCT) or a cyclic guanosine monophosphate (cGMP) analogue.
Report a problemFND-1505969404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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