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Study · Animal study (in vivo) · rat · 2004

6 results

Long-term modulation by postnatal oxytocin of the alpha 2-adrenoceptor agonist binding sites in central autonomic regions and the role of prenatal stress.

Díaz-Cabiale Z, Díaz-Cabiale Z, Olausson H, Sohlström A, Agnati LF, Narváez JA, Uvnäs-Moberg K, Fuxe K

Journal of neuroendocrinology1 Mar 2004Cited by 19 (Europe PMC)

PMID15049848 (opens in a new tab)DOI10.1111/j.0953-8194.2004.01146.x (opens in a new tab)PepBankPUB-15049848
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In male rat offspring of ad libitum fed dams, postnatal oxytocin significantly increased the density of alpha(2)-agonist binding sites in the nucleus of the solitary tract.

    In plain wordsIn rats, oxytocin given early in life raised the number of alpha(2) receptor binding sites in one brainstem area in adulthood.

    Peptide
    Oxytocin
    Outcome
    IncreaseAlpha(2)-agonist binding site density in the NTS (ad libitum fed dams)
    Study

    ratn: not reported in source

    Male rat offspring, receptor autoradiography of alpha(2)-agonist binding sites
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    In offspring from ad libitum fed dams, oxytocin treatment significantly increased the density of alpha(2)-agonist binding sites in the NTS and in the hypothalamus.
    1 context sentence
    Summary · context
    The aim of this work was to evaluate whether oxytocin administered in male rats subcutaneously early in life in the absence or presence of food restriction during pregnancy has life-long effects on the alpha(2)-agonist binding sites in the nucleus of the solitarii tract (NTS), in the hypothalamus an…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male rat offspring of ad libitum fed dams, postnatal oxytocin significantly increased the density of alpha(2)-agonist binding sites in the hypothalamus.

    In plain wordsIn rats, oxytocin given early in life raised the number of alpha(2) receptor binding sites in the hypothalamus in adulthood.

    Peptide
    Oxytocin
    Outcome
    IncreaseAlpha(2)-agonist binding site density in the hypothalamus (ad libitum fed dams)
    Study

    ratn: not reported in source

    Male rat offspring, receptor autoradiography of alpha(2)-agonist binding sites
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    In offspring from ad libitum fed dams, oxytocin treatment significantly increased the density of alpha(2)-agonist binding sites in the NTS and in the hypothalamus.
    1 context sentence
    Summary · context
    The aim of this work was to evaluate whether oxytocin administered in male rats subcutaneously early in life in the absence or presence of food restriction during pregnancy has life-long effects on the alpha(2)-agonist binding sites in the nucleus of the solitarii tract (NTS), in the hypothalamus an…
  3. 03AnimalAnimal study (in vivo)Mechanism

    In male rat offspring of ad libitum fed dams, postnatal oxytocin significantly increased the Kd of alpha(2)-agonist binding sites in the hypothalamus, but not in the other regions studied.

    In plain wordsIn rats, oxytocin given early in life changed the binding affinity of alpha(2) receptors in the hypothalamus, but not in other regions studied.

    Peptide
    Oxytocin
    Outcome
    IncreaseKd of alpha(2)-agonist binding sites in the hypothalamus (ad libitum fed dams)
    Study

    ratn: not reported in source

    Male rat offspring, receptor autoradiography of alpha(2)-agonist binding sites
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The K(d) value of the alpha(2)-agonist binding sites in the hypothalamus of these rats, but not in the other regions studied, was also significantly increased.
    1 context sentence
    Summary · context
    The aim of this work was to evaluate whether oxytocin administered in male rats subcutaneously early in life in the absence or presence of food restriction during pregnancy has life-long effects on the alpha(2)-agonist binding sites in the nucleus of the solitarii tract (NTS), in the hypothalamus an…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In male rat offspring of food-restricted dams, postnatal oxytocin significantly increased Bmax of alpha(2)-agonist binding sites in the hypothalamus.

    In plain wordsIn rats whose mothers were food restricted, oxytocin given early in life raised alpha(2) binding capacity in the hypothalamus.

    Peptide
    Oxytocin
    Outcome
    IncreaseBmax of alpha(2)-agonist binding sites in the hypothalamus (food-restricted dams)
    Study

    ratn: not reported in source

    Male rat offspring, receptor autoradiography of alpha(2)-agonist binding sites
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    In offspring from food-restricted dams, oxytocin treatment produced a significant increase of the B(max) values in the hypothalamus and the amygdala and the K(d) value of the alpha(2)-agonist binding sites in the NTS of these rats also was selectively and significantly increased.
    1 context sentence
    Summary · context
    The aim of this work was to evaluate whether oxytocin administered in male rats subcutaneously early in life in the absence or presence of food restriction during pregnancy has life-long effects on the alpha(2)-agonist binding sites in the nucleus of the solitarii tract (NTS), in the hypothalamus an…
  5. 05AnimalAnimal study (in vivo)Mechanism

    In male rat offspring of food-restricted dams, postnatal oxytocin significantly increased Bmax of alpha(2)-agonist binding sites in the amygdala.

    In plain wordsIn rats whose mothers were food restricted, oxytocin given early in life raised alpha(2) binding capacity in the amygdala.

    Peptide
    Oxytocin
    Outcome
    IncreaseBmax of alpha(2)-agonist binding sites in the amygdala (food-restricted dams)
    Study

    ratn: not reported in source

    Male rat offspring, receptor autoradiography of alpha(2)-agonist binding sites
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    In offspring from food-restricted dams, oxytocin treatment produced a significant increase of the B(max) values in the hypothalamus and the amygdala and the K(d) value of the alpha(2)-agonist binding sites in the NTS of these rats also was selectively and significantly increased.
    1 context sentence
    Summary · context
    The aim of this work was to evaluate whether oxytocin administered in male rats subcutaneously early in life in the absence or presence of food restriction during pregnancy has life-long effects on the alpha(2)-agonist binding sites in the nucleus of the solitarii tract (NTS), in the hypothalamus an…
  6. 06AnimalAnimal study (in vivo)Mechanism

    In male rat offspring of food-restricted dams, postnatal oxytocin selectively and significantly increased the Kd of alpha(2)-agonist binding sites in the nucleus of the solitary tract.

    In plain wordsIn rats whose mothers were food restricted, oxytocin given early in life changed alpha(2) binding affinity in one brainstem area.

    Peptide
    Oxytocin
    Outcome
    IncreaseKd of alpha(2)-agonist binding sites in the NTS (food-restricted dams)
    Study

    ratn: not reported in source

    Male rat offspring, receptor autoradiography of alpha(2)-agonist binding sites
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    In offspring from food-restricted dams, oxytocin treatment produced a significant increase of the B(max) values in the hypothalamus and the amygdala and the K(d) value of the alpha(2)-agonist binding sites in the NTS of these rats also was selectively and significantly increased.
    1 context sentence
    Summary · context
    The aim of this work was to evaluate whether oxytocin administered in male rats subcutaneously early in life in the absence or presence of food restriction during pregnancy has life-long effects on the alpha(2)-agonist binding sites in the nucleus of the solitarii tract (NTS), in the hypothalamus an…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

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