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Study · In vitro (cells) · rat · 2004

5 results

Protective peptides that are orally active and mechanistically nonchiral.

Brenneman DE, Spong CY, Hauser JM, Abebe D, Pinhasov A, Golian T, Gozes I

The Journal of pharmacology and experimental therapeutics8 Mar 2004Cited by 36 (Europe PMC)

PMID15007105 (opens in a new tab)DOI10.1124/jpet.103.063891 (opens in a new tab)PepBankPUB-15007105
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In rat cortical cultures with tetrodotoxin, l-NAPVSIPQ showed neuroprotective potency similar to its d-amino acid counterpart.

    In plain wordsIn lab tests, l-NAPVSIPQ had similar protective potency to d-NAPVSIPQ in rat cortical cultures with tetrodotoxin.

    Peptide
    Davunetide
    Outcome
    No significant changeNeuroprotective potency
    Study

    ratn: not reported in source

    Cerebral cortical cultures
    Comparator
    d-NAPVSIPQ
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In rat cerebral cortical test cultures cotreated with 1 microM tetrodotoxin, the d-amino acid peptides produced similar potency and efficacy for neuroprotection as that observed for their respective l-amino acid peptides.
    1 context sentence
    Summary · context
    In the present study, all d-amino acid peptides of NAPVSIPQ and SALLRSIPA were synthesized and compared respectively to the corresponding all l-amino acid peptides.
  2. 02LabIn vitro (cells)Efficacy outcome

    In rat cortical cultures with tetrodotoxin, l-NAPVSIPQ showed neuroprotective efficacy similar to its d-amino acid counterpart.

    In plain wordsIn lab tests, l-NAPVSIPQ had similar protective efficacy to d-NAPVSIPQ in rat cortical cultures with tetrodotoxin.

    Peptide
    Davunetide
    Outcome
    No significant changeNeuroprotective efficacy
    Study

    ratn: not reported in source

    Cerebral cortical cultures
    Comparator
    d-NAPVSIPQ
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In rat cerebral cortical test cultures cotreated with 1 microM tetrodotoxin, the d-amino acid peptides produced similar potency and efficacy for neuroprotection as that observed for their respective l-amino acid peptides.
    1 context sentence
    Summary · context
    In the present study, all d-amino acid peptides of NAPVSIPQ and SALLRSIPA were synthesized and compared respectively to the corresponding all l-amino acid peptides.
  3. 03LabIn vitro (cells)Activity measurement

    In rat cortical cultures, individually tested l-NAPVSIPQ exhibited attenuation of efficacy at concentrations above 10 pM.

    In plain wordsIn lab tests, l-NAPVSIPQ protection weakened at concentrations above 10 pM in rat cortical cultures.

    Peptide
    Davunetide
    Outcome
    DecreaseAttenuation of neuroprotective efficacy
    Study

    ratn: not reported in source

    Cerebral cortical cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    >10 pMAs given in this study (rat).

    Source sentences

    Summary
    Since all these peptides tested individually exhibited attenuation of efficacy at concentrations of >10 pM, combinations of these peptides were tested for possible synergies.
    2 context sentences
    Summary · context
    In the present study, all d-amino acid peptides of NAPVSIPQ and SALLRSIPA were synthesized and compared respectively to the corresponding all l-amino acid peptides. In rat cerebral cortical test cultures cotreated with 1 microM tetrodotoxin, the d-amino acid peptides produced similar potency and eff…
    Summary · context
    In the present study, all d-amino acid peptides of NAPVSIPQ and SALLRSIPA were synthesized and compared respectively to the corresponding all l-amino acid peptides.

Studies that did not test the peptide alone2

In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Davunetide.

  1. 04LabNot a test of Davunetide aloneIn vitro (cells)Activity measurement

    In rat cortical cultures, l-NAPVSIPQ plus d-SALLRSIPA produced neuroprotection with EC(50) of 0.07 fM.

    In plain wordsIn lab tests, l-NAPVSIPQ plus d-SALLRSIPA protected rat cortical cultures, with EC(50) of 0.07 fM.

    Peptide
    Davunetide
    Outcome
    Not applicableCombination neuroprotective potency
    Study

    ratn: not reported in source

    Cerebral cortical cultures
    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    EC(50)
    0.07 fM
    l-NAPVSIPQ plus d-SALLRSIPA

    Source sentences

    Summary
    Similarly, the combination of l-NAPVSIPQ and d-SALLRSIPA also had high potency (EC(50), 0.07 fM) without attenuation of efficacy.
    2 context sentences
    Summary · context
    In rat cerebral cortical test cultures cotreated with 1 microM tetrodotoxin, the d-amino acid peptides produced similar potency and efficacy for neuroprotection as that observed for their respective l-amino acid peptides.
    Summary · context
    In the present study, all d-amino acid peptides of NAPVSIPQ and SALLRSIPA were synthesized and compared respectively to the corresponding all l-amino acid peptides.

    In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.

  2. 05LabNot a test of Davunetide aloneIn vitro (cells)Activity measurement

    In rat cortical cultures, l-NAPVSIPQ plus d-SALLRSIPA showed no attenuation of neuroprotective efficacy with increasing concentrations.

    In plain wordsIn lab tests, protection from l-NAPVSIPQ plus d-SALLRSIPA did not weaken as concentrations increased.

    Peptide
    Davunetide
    Outcome
    No significant changeCombination efficacy with increasing concentration
    Study

    ratn: not reported in source

    Cerebral cortical cultures
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Similarly, the combination of l-NAPVSIPQ and d-SALLRSIPA also had high potency (EC(50), 0.07 fM) without attenuation of efficacy.
    2 context sentences
    Summary · context
    Equimolar d-NAPVSIPQ and d-SALLRSIPA combination treatment produced potent neuroprotection (EC(50), 0.03 fM) that did not attenuate with increasing concentrations.
    Summary · context
    In the present study, all d-amino acid peptides of NAPVSIPQ and SALLRSIPA were synthesized and compared respectively to the corresponding all l-amino acid peptides.

    In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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