Study · Other design · mouse · 2004

1 result

Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice.

Roseberry AG, Liu H, Jackson AC, Cai X, Friedman JM

Neuron1 Mar 2004Cited by 156 (Europe PMC)

PMID15003171DOI10.1016/s0896-6273(04)00074-1PepBankPUB-15003171

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

01LabOther designActivity measurement
In patch-clamp recordings of GFP-labeled NPY neurons, the alphaMSH analog melanotan II had no effect on neuron activity.
In plain wordsIn lab tests on mouse brain neurons, melanotan II did not change the activity of NPY neurons.
Peptide
Melanotan II
Outcome
No significant changeActivity of NPY neurons after MTII
Study
mousen: not reported in source
GFP-labeled NPY neurons, patch-clamp electrophysiology
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
the alphaMSH analog, MTII, had no effect on activity of NPY neurons.
Report a problemFND-1500317101

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

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