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Study · Not a test of the peptide alone · 2004

3 results

Short-term testosterone supplementation relieves growth hormone autonegative feedback in men.

Veldhuis JD, Evans WS, Iranmanesh A, Weltman AL, Bowers CY

The Journal of clinical endocrinology and metabolism1 Mar 2004Cited by 15 (Europe PMC)

PMID15001624 (opens in a new tab)DOI10.1210/jc.2003-031017 (opens in a new tab)PepBankPUB-15001624
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 01HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In healthy men aged 43-71 years, three weekly testosterone injections blunted GH secretion stimulated by GHRP‑2 by 1.9-fold compared with placebo.

    In plain wordsIn older healthy men, testosterone reduced the growth hormone rise caused by a GHRP‑2 test dose, compared with placebo.

    Peptide
    GHRP-2
    Outcome
    DecreaseGHRP-2-stimulated GH secretion after testosterone
    Study

    n = 13

    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Blunting of GHRP-2-stimulated GH secretion
    1.9 fold
    testosterone vs placebo

    Source sentences

    Summary
    3) blunted GHRP-2-stimulation by 1.9-fold (P < 0.01)
    2 context sentences
    Summary · context
    To this end, 13 healthy men (ages 43-71 yr) received three consecutive weekly im injections of placebo (Pl) (n = 7) or Te (200 mg) (n = 6) in a prospectively randomized, double-blind, parallel-cohort design.
    Summary · context
    An iv pulse of saline or recombinant human (rh)GH (3 micro g/kg.6 min) was infused 2 h before bolus saline or GH-releasing peptide (GHRP)-2 (1 micro g/kg) in the fasting state.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 02HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In healthy men given placebo, a recombinant human GH pulse suppressed GHRP‑2-stimulated GH secretion by 2.1-fold.

    In plain wordsIn healthy men on placebo, a dose of human growth hormone lowered the growth hormone release caused by a GHRP‑2 test dose.

    Peptide
    GHRP-2
    Outcome
    DecreaseGHRP-2-stimulated GH secretion after rhGH pulse
    Study

    n = 7

    Comparator
    Saline pulse
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Suppression of GHRP-2-stimulated GH secretion
    2.1 fold
    after placebo

    Source sentences

    Summary
    After Pl, rhGH suppressed basal, pulsatile, and GHRP-2-stimulated GH secretion by 2.6-, 2.4-, and 2.1-fold, respectively (each P < 0.03)
    2 context sentences
    Summary · context
    To this end, 13 healthy men (ages 43-71 yr) received three consecutive weekly im injections of placebo (Pl) (n = 7) or Te (200 mg) (n = 6) in a prospectively randomized, double-blind, parallel-cohort design.
    Summary · context
    An iv pulse of saline or recombinant human (rh)GH (3 micro g/kg.6 min) was infused 2 h before bolus saline or GH-releasing peptide (GHRP)-2 (1 micro g/kg) in the fasting state.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  3. 03HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In healthy men given placebo, a recombinant human GH pulse truncated GHRP‑2-stimulated GH secretory bursts.

    In plain wordsIn healthy men on placebo, a dose of human growth hormone shortened the bursts of growth hormone released after GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    DecreaseGHRP-2-stimulated GH secretory bursts after rhGH pulse
    Study

    n = 7

    Comparator
    Saline pulse
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    and truncated GHRP-2-stimulated GH secretory bursts (P < 0.005).
    2 context sentences
    Summary · context
    To this end, 13 healthy men (ages 43-71 yr) received three consecutive weekly im injections of placebo (Pl) (n = 7) or Te (200 mg) (n = 6) in a prospectively randomized, double-blind, parallel-cohort design.
    Summary · context
    An iv pulse of saline or recombinant human (rh)GH (3 micro g/kg.6 min) was infused 2 h before bolus saline or GH-releasing peptide (GHRP)-2 (1 micro g/kg) in the fasting state.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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