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Study · Animal study (in vivo) · mouse · 2004

11 results

Activation of tumor-associated macrophages by thymosin alpha 1.

Shrivastava P, Singh SM, Singh N

International journal of immunopathology and pharmacology1 Jan 2004Cited by 18 (Europe PMC)

PMID15000865 (opens in a new tab)DOI10.1177/039463200401700106 (opens in a new tab)PepBankPUB-15000865
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice bearing Dalton's lymphoma, intraperitoneal thymosin alpha‑1 activated tumor-associated macrophages.

    In plain wordsIn mice with a T-cell lymphoma, thymosin alpha‑1 injected into the abdomen activated tumor-associated macrophages.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseTumor-associated macrophage activation in vivo
    Study

    mousen: not reported in source

    Dalton's lymphoma-bearing mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    It was observed that intraperitoneal administration of thymosin alpha 1 to DL-bearing mice resulted in activation of TAM.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Dalton's lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages produced more interleukin-1.

    In plain wordsIn lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages made more interleukin-1.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseIL-1 production by TAM
    Study

    mousen: not reported in source

    Dalton's lymphoma-bearing mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Such TAM were found to produce enhanced amount of interleukin-1 (IL-1), tumor necrosis factor (TNF), reactive oxygen intermediates (ROI), nitric oxide (NO) and showed an increased abilities of pinocytosis, phagocytosis, antigen presentation and tumor cytotoxicity.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In Dalton's lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages produced more tumor necrosis factor.

    In plain wordsIn lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages made more tumor necrosis factor.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseTNF production by TAM
    Study

    mousen: not reported in source

    Dalton's lymphoma-bearing mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Such TAM were found to produce enhanced amount of interleukin-1 (IL-1), tumor necrosis factor (TNF), reactive oxygen intermediates (ROI), nitric oxide (NO) and showed an increased abilities of pinocytosis, phagocytosis, antigen presentation and tumor cytotoxicity.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In Dalton's lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages produced more reactive oxygen intermediates.

    In plain wordsIn lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages made more reactive oxygen intermediates.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseReactive oxygen intermediate production by TAM
    Study

    mousen: not reported in source

    Dalton's lymphoma-bearing mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Such TAM were found to produce enhanced amount of interleukin-1 (IL-1), tumor necrosis factor (TNF), reactive oxygen intermediates (ROI), nitric oxide (NO) and showed an increased abilities of pinocytosis, phagocytosis, antigen presentation and tumor cytotoxicity.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In Dalton's lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages produced more nitric oxide.

    In plain wordsIn lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages made more nitric oxide.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseNitric oxide production by TAM
    Study

    mousen: not reported in source

    Dalton's lymphoma-bearing mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Such TAM were found to produce enhanced amount of interleukin-1 (IL-1), tumor necrosis factor (TNF), reactive oxygen intermediates (ROI), nitric oxide (NO) and showed an increased abilities of pinocytosis, phagocytosis, antigen presentation and tumor cytotoxicity.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In Dalton's lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages showed increased pinocytosis.

    In plain wordsIn lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages took up more fluid by pinocytosis.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePinocytosis by TAM
    Study

    mousen: not reported in source

    Dalton's lymphoma-bearing mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Such TAM were found to produce enhanced amount of interleukin-1 (IL-1), tumor necrosis factor (TNF), reactive oxygen intermediates (ROI), nitric oxide (NO) and showed an increased abilities of pinocytosis, phagocytosis, antigen presentation and tumor cytotoxicity.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In Dalton's lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages showed increased phagocytosis.

    In plain wordsIn lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages engulfed more particles.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePhagocytosis by TAM
    Study

    mousen: not reported in source

    Dalton's lymphoma-bearing mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Such TAM were found to produce enhanced amount of interleukin-1 (IL-1), tumor necrosis factor (TNF), reactive oxygen intermediates (ROI), nitric oxide (NO) and showed an increased abilities of pinocytosis, phagocytosis, antigen presentation and tumor cytotoxicity.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In Dalton's lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages showed increased antigen presentation.

    In plain wordsIn lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages showed more antigen presentation.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAntigen presentation by TAM
    Study

    mousen: not reported in source

    Dalton's lymphoma-bearing mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Such TAM were found to produce enhanced amount of interleukin-1 (IL-1), tumor necrosis factor (TNF), reactive oxygen intermediates (ROI), nitric oxide (NO) and showed an increased abilities of pinocytosis, phagocytosis, antigen presentation and tumor cytotoxicity.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In Dalton's lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages showed increased tumor cytotoxicity.

    In plain wordsIn lymphoma-bearing mice given thymosin alpha‑1, tumor-associated macrophages killed more tumor cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseTumor cytotoxicity of TAM
    Study

    mousen: not reported in source

    Dalton's lymphoma-bearing mice
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Such TAM were found to produce enhanced amount of interleukin-1 (IL-1), tumor necrosis factor (TNF), reactive oxygen intermediates (ROI), nitric oxide (NO) and showed an increased abilities of pinocytosis, phagocytosis, antigen presentation and tumor cytotoxicity.
  10. 10LabIn vitro (cells)Mechanism

    In vitro treatment of tumor-associated macrophages with thymosin alpha‑1 activated them to a tumoricidal state.

    In plain wordsIn cells, thymosin alpha‑1 activated tumor-associated macrophages to a state that kills tumor cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseTAM activation to tumoricidal state in vitro
    Study

    mousen: not reported in source

    Tumor-associated macrophages treated in vitro
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The TAM were found to be directly responsive to thymosin alpha1 as in vitro treatment with thymosin alpha 1 could activate TAM to tumoricidal state.
  11. 11LabIn vitro (cells)Mechanism

    Treatment of tumor-associated macrophages with thymosin alpha‑1 enhanced their responsiveness to LPS.

    In plain wordsIn cells, thymosin alpha‑1 made tumor-associated macrophages respond more strongly to LPS.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseLPS responsiveness of TAM
    Study

    mousen: not reported in source

    Tumor-associated macrophages treated in vitro
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment of TAM with thymosin alpha 1 also enhanced their LPS responsiveness for an augmented state of activation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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