By NMR, the cyclic alpha-MSH analogues, including MTII, had similar backbone structures, with beta-turns spanning His6 and D-Phe7 or D-Nal7.
In plain wordsIn lab tests, MTII and related cyclic peptides showed similar three-dimensional shapes with a turn near the key amino acids.
- Peptide
- Melanotan II
- Outcome
- Not applicableBackbone structure of cyclic melanocortin analogues including MTII
- Study
n: not reported in source
2D NMR in water at pH 4.5 and 25 degrees C- Outcome group
- Receptor activity and mechanism · Pharmacology
Source sentences
beta-Turns spanning His(6) and D-Phe(7)/D-Nal(2')(7) were identified in all analogues, and an amphiphilic molecular surface was obtained for the message sequence residues in most structures within the NMR ensembles.
1 context sentence(design, population, supporting numbers)
The solution structures of the cyclic melanocortin agonists, partial agonist, and antagonists MTII, VJH085, SHU9119, MK5, and MK9 were determined by two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy at pH 4.5 and 25 degrees C in water (90% H(2)O/10% D(2)O).
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.