Skip to content

Study · Measured the body's own peptide · 2004

7 results

Expression of the arginine vasopressin gene in response to salt loading in oxytocin gene knockout mice.

Ozaki Y, Nomura M, Saito J, Luedke CE, Muglia LJ, Matsumoto T, Ogawa S, Ueta Y, Pfaff DW

Journal of neuroendocrinology1 Jan 2004Cited by 14 (Europe PMC)

PMID14962074 (opens in a new tab)DOI10.1111/j.1365-2826.2004.01119.x (opens in a new tab)PepBankPUB-14962074
Publisher pagePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mice, basal oxytocin mRNA in the paraventricular and supraoptic nuclei was significantly lower in heterozygous knockout mice than in wild-type mice.

    In plain wordsIn mice, the body's own oxytocin gene activity in two brain areas was lower with one working gene copy than in normal mice.

    Peptide
    Oxytocin
    Outcome
    DecreaseBasal oxytocin mRNA in heterozygous mice
    Study

    mousen: not reported in source

    Oxytocin gene knockout, heterozygous and wild-type mice
    Comparator
    Wild-type mice
    Outcome group
    Brain and neuronal activity · Endocrine and hormones

    Source sentences

    Summary
    The basal levels of oxytocin mRNA in the PVN and SON of heterozygous mice were significantly lower than those in wild-type mice.
    1 context sentence
    Summary · context
    In the present study, we examined the effects of salt loading (drinking 2% NaCl for 5 days) on the expression of the AVP gene in the paraventricular (PVN) and supraoptic nuclei (SON) of wild-type, OTKO and heterozygous littermates using in situ hybridization histochemistry.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In wild-type and heterozygous mice, salt loading increased oxytocin mRNA levels in the paraventricular and supraoptic nuclei.

    In plain wordsIn mice, salt loading raised the body's own oxytocin gene activity in two brain areas.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin mRNA after salt loading
    Study

    mousen: not reported in source

    Oxytocin gene knockout, heterozygous and wild-type mice
    Comparator
    Non salt-loaded mice
    Outcome group
    Brain and neuronal activity · Endocrine and hormones

    Source sentences

    Summary
    Salt loading caused an increase of oxytocin mRNA levels in the PVN and SON of both wild-type and heterozygous mice.
    1 context sentence
    Summary · context
    In the present study, we examined the effects of salt loading (drinking 2% NaCl for 5 days) on the expression of the AVP gene in the paraventricular (PVN) and supraoptic nuclei (SON) of wild-type, OTKO and heterozygous littermates using in situ hybridization histochemistry.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mice, the ratios of increase of oxytocin mRNA after salt loading were very similar in wild-type and heterozygous mice.

    In plain wordsIn mice, salt loading raised the body's own oxytocin gene activity by a similar ratio in normal mice and in mice with one working copy.

    Peptide
    Oxytocin
    Outcome
    No significant changeRatio of oxytocin mRNA increase after salt loading, heterozygous versus wild-type
    Study

    mousen: not reported in source

    Oxytocin gene knockout, heterozygous and wild-type mice
    Comparator
    Wild-type mice
    Outcome group
    Brain and neuronal activity · Endocrine and hormones

    Source sentences

    Summary
    The ratios of increase of oxytocin mRNA levels were very similar between wild-type and heterozygous mice, suggesting that the single remaining oxytocin gene in heterozygous mice responds normally to an osmotic cue.
    1 context sentence
    Summary · context
    In the present study, we examined the effects of salt loading (drinking 2% NaCl for 5 days) on the expression of the AVP gene in the paraventricular (PVN) and supraoptic nuclei (SON) of wild-type, OTKO and heterozygous littermates using in situ hybridization histochemistry.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In mice, loss of the oxytocin gene lowered arginine vasopressin mRNA in the paraventricular and supraoptic nuclei compared with wild-type mice without salt loading.

    In plain wordsIn mice, lacking the oxytocin gene lowered vasopressin gene activity in two brain areas compared with normal mice.

    Peptide
    Oxytocin
    Outcome
    DecreaseAVP mRNA in PVN and SON under non salt-loaded condition
    Study

    mousen: not reported in source

    Oxytocin gene knockout, heterozygous and wild-type mice
    Comparator
    Wild-type mice
    Outcome group
    Brain and neuronal activity · Endocrine and hormones

    Source sentences

    Summary
    Under the non salt-loaded condition, the levels of AVP mRNA in the PVN and SON of OTKO mice were significantly decreased compared to those in wild-type mice.
    1 context sentence
    Summary · context
    In the present study, we examined the effects of salt loading (drinking 2% NaCl for 5 days) on the expression of the AVP gene in the paraventricular (PVN) and supraoptic nuclei (SON) of wild-type, OTKO and heterozygous littermates using in situ hybridization histochemistry.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In mice lacking the oxytocin gene, salt loading still up-regulated arginine vasopressin gene expression.

    In plain wordsIn mice lacking the oxytocin gene, salt loading still raised vasopressin gene activity.

    Peptide
    Oxytocin
    Outcome
    IncreaseAVP gene up-regulation after salt loading in OTKO mice
    Study

    mousen: not reported in source

    Oxytocin gene knockout, heterozygous and wild-type mice
    Comparator
    Non salt-loaded OTKO mice
    Outcome group
    Brain and neuronal activity · Endocrine and hormones

    Source sentences

    Summary
    Nevertheless, the up-regulation of the expression of the AVP gene in response to salt loading was preserved in OTKO mice.
    1 context sentence
    Summary · context
    In the present study, we examined the effects of salt loading (drinking 2% NaCl for 5 days) on the expression of the AVP gene in the paraventricular (PVN) and supraoptic nuclei (SON) of wild-type, OTKO and heterozygous littermates using in situ hybridization histochemistry.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In mice lacking the oxytocin gene, the up-regulation of arginine vasopressin expression after salt loading tended to be greater than in wild-type mice, without a stated significant difference.

    In plain wordsIn mice lacking the oxytocin gene, the rise in vasopressin gene activity after salt loading tended to be larger than in normal mice.

    Peptide
    Oxytocin
    Outcome
    No significant changeDegree of AVP up-regulation after salt loading, OTKO versus wild-type
    Study

    mousen: not reported in source

    Oxytocin gene knockout, heterozygous and wild-type mice
    Comparator
    Wild-type mice
    Outcome group
    Brain and neuronal activity · Endocrine and hormones

    Source sentences

    Summary
    The degree of the up-regulation in OTKO mice tended to be greater compared to those in wild-type mice, suggesting compensatory up-regulation of the expression of the AVP gene in OTKO mice after salt loading.
    1 context sentence
    Summary · context
    In the present study, we examined the effects of salt loading (drinking 2% NaCl for 5 days) on the expression of the AVP gene in the paraventricular (PVN) and supraoptic nuclei (SON) of wild-type, OTKO and heterozygous littermates using in situ hybridization histochemistry.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 07AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In mice, salt loading tended to increase serum sodium regardless of genotype, with no genotype differences in the control and salt-loaded groups.

    In plain wordsIn mice, salt loading tended to raise blood sodium in all genotypes, and the genotypes did not differ.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerum sodium by genotype after salt loading
    Study

    mousen: not reported in source

    Oxytocin gene knockout, heterozygous and wild-type mice
    Comparator
    Wild-type mice
    Outcome group
    Brain and neuronal activity · Endocrine and hormones

    Source sentences

    Summary
    Finally, salt loading tended to increase the serum concentration of sodium regardless of genotype, and there were no genotype differences in both the control and salt-loaded groups.
    1 context sentence
    Summary · context
    In the present study, we examined the effects of salt loading (drinking 2% NaCl for 5 days) on the expression of the AVP gene in the paraventricular (PVN) and supraoptic nuclei (SON) of wild-type, OTKO and heterozygous littermates using in situ hybridization histochemistry.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.