Responses of cells in the rat supraoptic nucleus in vivo to stimulation of afferent pathways are different at different times of the light/dark cycle.

Saeb-Parsy K, Dyball RE

Journal of neuroendocrinology1 Feb 2004Cited by 9 (Europe PMC)

PMID14763999DOI10.1111/j.0953-8194.2004.01142.xPepBankPUB-14763999

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anaesthetized rats, about 27% of supraoptic cells classified as oxytocin neurones (29/108) were excited by optic nerve stimulation.
In plain wordsIn rats, about a quarter of cells classified as oxytocin neurones fired more when the optic nerve was stimulated.
Peptide
Oxytocin
Outcome
Not applicableOxytocin neurones excited by optic nerve stimulation
Study
ratn: not reported in source
Anaesthetized rats, extracellular single cell recordings in the supraoptic nucleus
Outcome group
Brain and neuronal activity · Nervous system and cognition
Source sentences
Summary
Approximately 27% of both oxytocin (29/108) and vasopressin (39/147) neurones were excited by stimulation of the optic nerve, and the majority of responses had a long latency (>20 ms).
2 context sentences(design, population, supporting numbers)
Summary · context
To determine whether the daily rhythms of spike activity in the supraoptic nucleus (SON) were accompanied by changes in the behaviour of its inputs, we used conventional extracellular single cell recordings from cells in the SON of anaesthetized rats while stimulating the contralateral optic nerve a…
Summary · context
Neurones in the SON region were identified by antidromic activation and classified as oxytocin or vasopressin cells, on the basis of their spontaneous firing patterns.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1476399901
02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anaesthetized rats, very few supraoptic cells classified as oxytocin neurones (3/108) were inhibited by optic nerve stimulation.
In plain wordsIn rats, very few cells classified as oxytocin neurones fired less when the optic nerve was stimulated.
Peptide
Oxytocin
Outcome
Not applicableOxytocin neurones inhibited by optic nerve stimulation
Study
ratn: not reported in source
Anaesthetized rats, extracellular single cell recordings in the supraoptic nucleus
Outcome group
Brain and neuronal activity · Nervous system and cognition
Source sentences
Summary
Very few oxytocin (3/108) and vasopressin cells (2/147) were inhibited by stimulation of the optic nerve.
2 context sentences(design, population, supporting numbers)
Summary · context
To determine whether the daily rhythms of spike activity in the supraoptic nucleus (SON) were accompanied by changes in the behaviour of its inputs, we used conventional extracellular single cell recordings from cells in the SON of anaesthetized rats while stimulating the contralateral optic nerve a…
Summary · context
Neurones in the SON region were identified by antidromic activation and classified as oxytocin or vasopressin cells, on the basis of their spontaneous firing patterns.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1476399902
03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anaesthetized rats, responses of cells classified as oxytocin neurones to optic nerve stimulation were significantly related to time of day (P = 0.012).
In plain wordsIn rats, responses of cells classified as oxytocin neurones to optic nerve stimulation varied with the time of day.
Peptide
Oxytocin
Outcome
MixedOxytocin neurone response pattern to optic nerve stimulation by time of day
Study
ratn: not reported in source
Anaesthetized rats, extracellular single cell recordings in the supraoptic nucleus
Outcome group
Brain and neuronal activity · Nervous system and cognition
Source sentences
Summary
The pattern of the responses (excitatory, inhibitory or nonresponsive) of oxytocin and vasopressin cells to stimulation of the optic nerve was significantly related to the time of day (chi-square test; P = 0.012, oxytocin cells
2 context sentences(design, population, supporting numbers)
Summary · context
To determine whether the daily rhythms of spike activity in the supraoptic nucleus (SON) were accompanied by changes in the behaviour of its inputs, we used conventional extracellular single cell recordings from cells in the SON of anaesthetized rats while stimulating the contralateral optic nerve a…
Summary · context
Neurones in the SON region were identified by antidromic activation and classified as oxytocin or vasopressin cells, on the basis of their spontaneous firing patterns.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1476399903
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anaesthetized rats, the proportion of cells classified as oxytocin neurones excited by optic nerve stimulation was highest at ZT 4-8 and lowest at ZT 20-24.
In plain wordsIn rats, optic-nerve stimulation excited the largest share of classified oxytocin cells at ZT 4-8 and the smallest at ZT 20-24.
Peptide
Oxytocin
Outcome
MixedProportion of oxytocin cells excited by optic nerve stimulation across the light/dark cycle
Study
ratn: not reported in source
Anaesthetized rats, extracellular single cell recordings in the supraoptic nucleus
Outcome group
Brain and neuronal activity · Nervous system and cognition
Source sentences
Summary
The proportion of oxytocin cells excited by stimulation of the optic nerve was highest at ZT 4-8 and lowest at ZT 20-24.
2 context sentences(design, population, supporting numbers)
Summary · context
To determine whether the daily rhythms of spike activity in the supraoptic nucleus (SON) were accompanied by changes in the behaviour of its inputs, we used conventional extracellular single cell recordings from cells in the SON of anaesthetized rats while stimulating the contralateral optic nerve a…
Summary · context
Neurones in the SON region were identified by antidromic activation and classified as oxytocin or vasopressin cells, on the basis of their spontaneous firing patterns.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1476399904
05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anaesthetized rats, responses of cells classified as oxytocin neurones to suprachiasmatic nucleus stimulation differed significantly by time of day (P = 0.029).
In plain wordsIn rats, responses of cells classified as oxytocin neurones to body-clock-area stimulation varied with the time of day.
Peptide
Oxytocin
Outcome
MixedOxytocin cell responses to suprachiasmatic nucleus stimulation by time of day
Study
ratn: not reported in source
Anaesthetized rats, extracellular single cell recordings in the supraoptic nucleus
Outcome group
Brain and neuronal activity · Nervous system and cognition
Source sentences
Summary
The proportion of excitatory, inhibitory and complex responses seen in oxytocin and vasopressin cells following stimulation of the SCN also changed and was significantly different at different times of day (oxytocin cells: highest proportion of excitatory responses at ZT 12-16, P = 0.029
2 context sentences(design, population, supporting numbers)
Summary · context
To determine whether the daily rhythms of spike activity in the supraoptic nucleus (SON) were accompanied by changes in the behaviour of its inputs, we used conventional extracellular single cell recordings from cells in the SON of anaesthetized rats while stimulating the contralateral optic nerve a…
Summary · context
Neurones in the SON region were identified by antidromic activation and classified as oxytocin or vasopressin cells, on the basis of their spontaneous firing patterns.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1476399905

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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