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Study · In vitro (cells) · sheep · 2004

7 results

Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH, pituitary transcription factor-1, GHRH-receptor, GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells.

Yan M, Hernandez M, Xu R, Chen C

European journal of endocrinology1 Feb 2004Cited by 17 (Europe PMC)

PMID14763922 (opens in a new tab)DOI10.1530/eje.0.1500235 (opens in a new tab)PepBankPUB-14763922
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In ovine pituitary somatotropes, GHRP‑2 increased GH mRNA levels from 0.5 to 2 h in a time-dependent manner.

    In plain wordsIn sheep pituitary cells, GHRP‑2 raised growth hormone gene activity over 2 hours.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH mRNA level
    Study

    sheepn: not reported in source

    Ovine pituitary somatotropes
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 nM · 0.5 to 2 hAs given in this study (sheep).

    Source sentences

    Summary
    GHRH (10 nM), GHRP-2 (100 nM) and combined GHRH-GHRP-2 increased the levels of GH mRNA and GH release from 0.5 to 2 h in a time-dependent manner.
    1 context sentence
    Summary · context
    To clarify the mechanism of action, ovine somatotropes were used to measure the expression of mRNAs encoding for GH, pituitary transcription factor-1 (Pit-1), GH-secretagogue receptor (GHS-R), GHRH-R, somatostatin receptor subtypes (sst-1 and sst-2) and GH release after GHRH and GHRP-2 treatment for…
  2. 02LabIn vitro (cells)Mechanism

    In ovine pituitary somatotropes, GHRP‑2 increased GH release from 0.5 to 2 h in a time-dependent manner.

    In plain wordsIn sheep pituitary cells, GHRP‑2 raised growth hormone release over 2 hours.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH release
    Study

    sheepn: not reported in source

    Ovine pituitary somatotropes
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 nM · 0.5 to 2 hAs given in this study (sheep).

    Source sentences

    Summary
    GHRH (10 nM), GHRP-2 (100 nM) and combined GHRH-GHRP-2 increased the levels of GH mRNA and GH release from 0.5 to 2 h in a time-dependent manner.
    1 context sentence
    Summary · context
    To clarify the mechanism of action, ovine somatotropes were used to measure the expression of mRNAs encoding for GH, pituitary transcription factor-1 (Pit-1), GH-secretagogue receptor (GHS-R), GHRH-R, somatostatin receptor subtypes (sst-1 and sst-2) and GH release after GHRH and GHRP-2 treatment for…
  3. 03LabIn vitro (cells)Mechanism

    In ovine pituitary somatotropes, GHRP‑2 increased Pit-1 mRNA after 0.5 h.

    In plain wordsIn sheep pituitary cells, GHRP‑2 raised Pit-1 gene activity after half an hour.

    Peptide
    GHRP-2
    Outcome
    IncreasePit-1 mRNA level
    Study

    sheepn: not reported in source

    Ovine pituitary somatotropes
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 nM · 0.5 hAs given in this study (sheep).

    Source sentences

    Summary
    The levels of Pit-1, GHRH-R and GHS-R mRNA were increased after 0.5 h treatment of cells with GHRH and GHRP-2.
    1 context sentence
    Summary · context
    To clarify the mechanism of action, ovine somatotropes were used to measure the expression of mRNAs encoding for GH, pituitary transcription factor-1 (Pit-1), GH-secretagogue receptor (GHS-R), GHRH-R, somatostatin receptor subtypes (sst-1 and sst-2) and GH release after GHRH and GHRP-2 treatment for…
  4. 04LabIn vitro (cells)Mechanism

    In ovine pituitary somatotropes, GHRP‑2 increased GHRH-R mRNA after 0.5 h.

    In plain wordsIn sheep pituitary cells, GHRP‑2 raised GHRH receptor gene activity after half an hour.

    Peptide
    GHRP-2
    Outcome
    IncreaseGHRH-R mRNA level
    Study

    sheepn: not reported in source

    Ovine pituitary somatotropes
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 nM · 0.5 hAs given in this study (sheep).

    Source sentences

    Summary
    The levels of Pit-1, GHRH-R and GHS-R mRNA were increased after 0.5 h treatment of cells with GHRH and GHRP-2.
    1 context sentence
    Summary · context
    To clarify the mechanism of action, ovine somatotropes were used to measure the expression of mRNAs encoding for GH, pituitary transcription factor-1 (Pit-1), GH-secretagogue receptor (GHS-R), GHRH-R, somatostatin receptor subtypes (sst-1 and sst-2) and GH release after GHRH and GHRP-2 treatment for…
  5. 05LabIn vitro (cells)Mechanism

    In ovine pituitary somatotropes, GHRP‑2 increased GHS-R mRNA after 0.5 h.

    In plain wordsIn sheep pituitary cells, GHRP‑2 raised GH secretagogue receptor gene activity after half an hour.

    Peptide
    GHRP-2
    Outcome
    IncreaseGHS-R mRNA level
    Study

    sheepn: not reported in source

    Ovine pituitary somatotropes
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 nM · 0.5 hAs given in this study (sheep).

    Source sentences

    Summary
    The levels of Pit-1, GHRH-R and GHS-R mRNA were increased after 0.5 h treatment of cells with GHRH and GHRP-2.
    1 context sentence
    Summary · context
    To clarify the mechanism of action, ovine somatotropes were used to measure the expression of mRNAs encoding for GH, pituitary transcription factor-1 (Pit-1), GH-secretagogue receptor (GHS-R), GHRH-R, somatostatin receptor subtypes (sst-1 and sst-2) and GH release after GHRH and GHRP-2 treatment for…
  6. 06LabIn vitro (cells)Mechanism

    In ovine pituitary somatotropes, GHRP‑2 inhibited sst-1 mRNA expression after 0.5-2 h.

    In plain wordsIn sheep pituitary cells, GHRP‑2 lowered somatostatin receptor 1 gene activity over 2 hours.

    Peptide
    GHRP-2
    Outcome
    Decreasesst-1 mRNA level
    Study

    sheepn: not reported in source

    Ovine pituitary somatotropes
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 nM · 0.5-2 hAs given in this study (sheep).

    Source sentences

    Summary
    In contrast, both sst-1 and sst-2 mRNA expression was inhibited after 0.5-2 h of GHRP treatment.
    1 context sentence
    Summary · context
    To clarify the mechanism of action, ovine somatotropes were used to measure the expression of mRNAs encoding for GH, pituitary transcription factor-1 (Pit-1), GH-secretagogue receptor (GHS-R), GHRH-R, somatostatin receptor subtypes (sst-1 and sst-2) and GH release after GHRH and GHRP-2 treatment for…
  7. 07LabIn vitro (cells)Mechanism

    In ovine pituitary somatotropes, GHRP‑2 inhibited sst-2 mRNA expression after 0.5-2 h.

    In plain wordsIn sheep pituitary cells, GHRP‑2 lowered somatostatin receptor 2 gene activity over 2 hours.

    Peptide
    GHRP-2
    Outcome
    Decreasesst-2 mRNA level
    Study

    sheepn: not reported in source

    Ovine pituitary somatotropes
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 nM · 0.5-2 hAs given in this study (sheep).

    Source sentences

    Summary
    In contrast, both sst-1 and sst-2 mRNA expression was inhibited after 0.5-2 h of GHRP treatment.
    1 context sentence
    Summary · context
    To clarify the mechanism of action, ovine somatotropes were used to measure the expression of mRNAs encoding for GH, pituitary transcription factor-1 (Pit-1), GH-secretagogue receptor (GHS-R), GHRH-R, somatostatin receptor subtypes (sst-1 and sst-2) and GH release after GHRH and GHRP-2 treatment for…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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