Skip to content

Study · Animal study (in vivo) · rat · 2004

3 results

Protective effect of vasoactive intestinal peptide on testicular torsion-detorsion injury: association with heparin-containing mast cells.

Can C, Töre F, Tunçel N, Uysal O, Gürer F, Ak D, Tunçel M

Urology1 Jan 2004Cited by 26 (Europe PMC)

PMID14751391 (opens in a new tab)DOI10.1016/j.urology.2003.08.010 (opens in a new tab)PepBankPUB-14751391
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal rats with testicular torsion and detorsion, VIP protected the testicular tissue from detorsion injury compared with saline.

    In plain wordsIn young rats with testicular torsion, VIP protected the testis from injury after blood flow returned, compared with saline.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseTesticular tissue damage after detorsion
    Study

    ratn: not reported in source

    Prepubertal male Sprague-Dawley rats with testicular torsion-detorsion
    Comparator
    Saline
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    25 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    VIP significantly protected the testicular tissue from detorsion injury.
    2 context sentences
    Summary · context
    Prepubertal male Sprague-Dawley rats were used in six groups.
    Summary · context
    VIP (25 ng/kg) was injected intraperitoneally 1 minute before the 1 and 4 hours of detorsion.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In prepubertal rats with testicular torsion and detorsion, VIP inhibited mast cell activity in the testes.

    In plain wordsIn young rats with testicular torsion, VIP reduced mast cell activity in the testis.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseMast cell activity
    Study

    ratn: not reported in source

    Prepubertal male Sprague-Dawley rats with testicular torsion-detorsion
    Comparator
    Saline
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    25 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    It also inhibited mast cell activity while increasing the heparin content.
    2 context sentences
    Summary · context
    Prepubertal male Sprague-Dawley rats were used in six groups.
    Summary · context
    VIP (25 ng/kg) was injected intraperitoneally 1 minute before the 1 and 4 hours of detorsion.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In prepubertal rats with testicular torsion and detorsion, VIP increased the heparin content of testicular mast cells.

    In plain wordsIn young rats with testicular torsion, VIP raised the heparin content in the testis.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseHeparin content of testicular mast cells
    Study

    ratn: not reported in source

    Prepubertal male Sprague-Dawley rats with testicular torsion-detorsion
    Comparator
    Saline
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    25 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    It also inhibited mast cell activity while increasing the heparin content.
    2 context sentences
    Summary · context
    Prepubertal male Sprague-Dawley rats were used in six groups.
    Summary · context
    VIP (25 ng/kg) was injected intraperitoneally 1 minute before the 1 and 4 hours of detorsion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.