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Study · Animal study (in vivo) · mouse · 2003

5 results

[Combined effect of vilon and cyclophosphane on tumor transplants and lymphoid tissue explants in mice and rats of various age].

Barykina OP, Iuzhakov VV, Chalisova NI, Kvetnoĭ IM, Konovalov SS

Advances in gerontology = Uspekhi gerontologii1 Jan 2003Cited by 1 (Europe PMC)

PMID14743610 (opens in a new tab)PepBankPUB-14743610
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with transplanted Lewis lung carcinoma, Vilon injections significantly increased survival.

    In plain wordsIn mice with transplanted lung tumors, Vilon increased survival.

    Peptide
    Vilon (KE)
    Outcome
    IncreaseSurvival with Vilon alone
    Study

    mousen: not reported in source

    Transplanted Lewis lung carcinoma
    Outcome group
    Mortality · Cancer
    Studied dose
    1 mg/kg · injectionAs given in this study (mouse).

    Source sentences

    Summary
    The injections of synthetic peptide vilon at the doses 1 mg/kg significantly increased the survival of mice.
    1 context sentence
    Summary · context
    The experiments were performed in mice with transplanted Lewis lung carcinoma.
  2. 02LabEx vivo tissueEfficacy outcome

    In spleen cultures from young rats, Vilon stimulated apoptosis.

    In plain wordsIn lab tests, Vilon increased cell death in spleen cultures from young rats.

    Peptide
    Vilon (KE)
    Outcome
    IncreaseApoptosis in young spleen explants
    Study

    ratn: not reported in source

    Spleen organotypic explants from young and old rats
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vilon stimulated apoptosis both in young and old rats,
    1 context sentence
    Summary · context
    There was also studied in spleen organotypic tissue culture the effect of vilon and cyclophosphan on the development of explants of rats of various age: 1 day and 2 years old.
  3. 03LabEx vivo tissueEfficacy outcome

    In spleen cultures from old rats, Vilon stimulated apoptosis.

    In plain wordsIn lab tests, Vilon increased cell death in spleen cultures from old rats.

    Peptide
    Vilon (KE)
    Outcome
    IncreaseApoptosis in old spleen explants
    Study

    ratn: not reported in source

    Spleen organotypic explants from young and old rats
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vilon stimulated apoptosis both in young and old rats,
    1 context sentence
    Summary · context
    There was also studied in spleen organotypic tissue culture the effect of vilon and cyclophosphan on the development of explants of rats of various age: 1 day and 2 years old.
  4. 04LabEx vivo tissueEfficacy outcome

    In rat spleen cultures, Vilon abolished cyclophosphan's inhibitory effect on explant development.

    In plain wordsIn lab tests, adding Vilon removed cyclophosphan's inhibition of rat spleen explant development.

    Peptide
    Vilon (KE)
    Outcome
    DecreaseCyclophosphan inhibition of explant development
    Study

    ratn: not reported in source

    Spleen organotypic explants
    Comparator
    Cyclophosphan without Vilon
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    but the inhibitory effect of cyclophosphan was abolished in the presence of vilon in culture media at the dose 5 ng/ml.
    1 context sentence
    Summary · context
    There was also studied in spleen organotypic tissue culture the effect of vilon and cyclophosphan on the development of explants of rats of various age: 1 day and 2 years old.

Studies that did not test the peptide alone1

In this study, Vilon (KE) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vilon (KE).

  1. 05AnimalNot a test of Vilon (KE) aloneAnimal study (in vivo)Efficacy outcome

    In mice with transplanted Lewis lung carcinoma, synchronous Vilon and cyclophosphan injections decreased survival.

    In plain wordsIn mice with transplanted lung tumors, simultaneous Vilon and cyclophosphan treatment decreased survival.

    Peptide
    Vilon (KE)
    Outcome
    DecreaseSurvival with Vilon and cyclophosphan
    Study

    mousen: not reported in source

    Transplanted Lewis lung carcinoma
    Outcome group
    Mortality · Cancer

    Source sentences

    Summary
    The synchronous injection both of vilon and cyclophosphan at the doses 100 mg/kg decreases the survival of mice.
    1 context sentence
    Summary · context
    The experiments were performed in mice with transplanted Lewis lung carcinoma.

    In this study, Vilon (KE) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vilon (KE).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 17:05 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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