Centrally administered galanin modifies vasopressin and oxytocin release from the hypothalamo-neurohypophysial system of euhydrated and dehydrated rats.

Ciosek J, Cisowska A

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Dec 2003Cited by 14 (Europe PMC)

PMID14726616PepBankPUB-14726616

Publisher pageAsk about this study

Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Mechanism
In euhydrated rats, intracerebroventricular galanin did not change hypothalamic oxytocin content.
In plain wordsIn rats with normal water balance, galanin did not change the body's own oxytocin stored in the hypothalamus.
Peptide
Oxytocin
Outcome
No significant changeHypothalamic oxytocin content, euhydrated rats
Study
ratn: not reported in source
In vivo, intracerebroventricular galanin
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In not dehydrated rats intracerebroventricular (i.c.v.) injections of Gal did not affect the hypothalamic and neurohypophysial OT content, however, distinctly increased plasma OT concentration.
1 context sentence(design, population, supporting numbers)
Summary · context
Vasopressin and oxytocin content in the hypothalamus and neurohypophysis as well as plasma level of both neurohormones were studied after galanin treatment in euhydrated and dehydrated rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1472661601
02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In euhydrated rats, intracerebroventricular galanin did not change neurohypophysial oxytocin content.
In plain wordsIn rats with normal water balance, galanin did not change the body's own oxytocin stored in the pituitary's back lobe.
Peptide
Oxytocin
Outcome
No significant changeNeurohypophysial oxytocin content, euhydrated rats
Study
ratn: not reported in source
In vivo, intracerebroventricular galanin
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In not dehydrated rats intracerebroventricular (i.c.v.) injections of Gal did not affect the hypothalamic and neurohypophysial OT content, however, distinctly increased plasma OT concentration.
1 context sentence(design, population, supporting numbers)
Summary · context
Vasopressin and oxytocin content in the hypothalamus and neurohypophysis as well as plasma level of both neurohormones were studied after galanin treatment in euhydrated and dehydrated rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1472661602
03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In euhydrated rats, intracerebroventricular galanin increased plasma oxytocin concentration.
In plain wordsIn rats with normal water balance, galanin raised the body's own oxytocin level in blood.
Peptide
Oxytocin
Outcome
IncreasePlasma oxytocin concentration, euhydrated rats
Study
ratn: not reported in source
In vivo, intracerebroventricular galanin
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In not dehydrated rats intracerebroventricular (i.c.v.) injections of Gal did not affect the hypothalamic and neurohypophysial OT content, however, distinctly increased plasma OT concentration.
1 context sentence(design, population, supporting numbers)
Summary · context
Vasopressin and oxytocin content in the hypothalamus and neurohypophysis as well as plasma level of both neurohormones were studied after galanin treatment in euhydrated and dehydrated rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1472661603
04AnimalEndogenous levelAnimal study (in vivo)Mechanism
In water-deprived rats, intracerebroventricular galanin inhibited oxytocin release from the hypothalamo-neurohypophysial system.
In plain wordsIn rats deprived of water, galanin reduced release of the body's own oxytocin from the brain system that makes it.
Peptide
Oxytocin
Outcome
DecreaseOxytocin release from hypothalamo-neurohypophysial system, dehydrated rats
Study
ratn: not reported in source
In vivo, intracerebroventricular galanin
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Galanin, administered i.c.v. to rats deprived of water, distinctly inhibited AVP and OT release from the hypothalamo-neurohypophysial system.
1 context sentence(design, population, supporting numbers)
Summary · context
Vasopressin and oxytocin content in the hypothalamus and neurohypophysis as well as plasma level of both neurohormones were studied after galanin treatment in euhydrated and dehydrated rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1472661604
05AnimalEndogenous levelAnimal study (in vivo)Mechanism
In water-deprived rats, galanin treatment significantly lowered plasma oxytocin level.
In plain wordsIn rats deprived of water, galanin lowered the body's own oxytocin level in blood.
Peptide
Oxytocin
Outcome
DecreasePlasma oxytocin level, dehydrated rats
Study
ratn: not reported in source
In vivo, intracerebroventricular galanin
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Simultaneously, plasma AVP and OT level was significantly diminished after Gal treatment in dehydrated rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Vasopressin and oxytocin content in the hypothalamus and neurohypophysis as well as plasma level of both neurohormones were studied after galanin treatment in euhydrated and dehydrated rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1472661605

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.