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Study · Animal study (in vivo) · rat · 2003

4 results

Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax.

Umarova BA, Kopylova GN, Smirnova EA, Guseva AA, Zhuikova SE

Bulletin of experimental biology and medicine1 Oct 2003Cited by 2 (Europe PMC)

PMID14714073 (opens in a new tab)DOI10.1023/b:bebm.0000010942.14275.50 (opens in a new tab)PepBankPUB-14714073
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats under stress, intraperitoneal Semax 1 h before stress abolished the stress-induced increase in mast cell secretory activity.

    In plain wordsIn rats, Semax injected 1 hour before stress prevented the stress-related rise in mast cell secretion.

    Peptide
    Semax
    Outcome
    DecreaseStress-induced increase in mast cell secretory activity
    Study

    ratn: not reported in source

    Stress model, mesentery and subcutaneous fat mast cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.05 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect.
    1 context sentence
    Summary · context
    Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In unstressed animals, Semax did not modulate the secretory activity of mast cells.

    In plain wordsIn unstressed rats, Semax did not change mast cell secretion.

    Peptide
    Semax
    Outcome
    No significant changeMast cell secretory activity in unstressed animals
    Study

    ratn: not reported in source

    Unstressed animals, mast cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The test preparations did not modulate secretory activity of mast cells in unstressed animals.
  3. 03LabIn vitro (cells)Activity measurement

    In vitro, Semax prevented the activation of mast cells with synacten.

    In plain wordsIn cells, Semax prevented mast cells from being activated by synacten.

    Peptide
    Semax
    Outcome
    DecreaseMast cell activation by synacten
    Study

    n: not reported in source

    Mast cells in vitro
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten
  4. 04LabIn vitro (cells)Activity measurement

    In vitro, Semax prevented the activation of mast cells with acetylcholine.

    In plain wordsIn cells, Semax prevented mast cells from being activated by acetylcholine.

    Peptide
    Semax
    Outcome
    DecreaseMast cell activation by acetylcholine
    Study

    n: not reported in source

    Mast cells in vitro
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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