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Study · Animal study (in vivo) · rat · 2004

5 results

Melanocortin receptors mediate the excitatory effects of blood-borne murine leptin on hypothalamic paraventricular neurons in rat.

Zhang ZH, Felder RB

American journal of physiology. Regulatory, integrative and comparative physiology1 Feb 2004Cited by 28 (Europe PMC)

PMID14707012 (opens in a new tab)DOI10.1152/ajpregu.00504.2003 (opens in a new tab)PepBankPUB-14707012
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In anesthetized rats, intracerebroventricular MTII activated neurons of the hypothalamic paraventricular nucleus.

    In plain wordsIn anesthetized rats, MTII injected into the brain activated neurons in a hypothalamic region.

    Peptide
    Melanotan II
    Outcome
    IncreaseActivation of paraventricular nucleus neurons
    Study

    ratn: not reported in source

    Urethane-anesthetized rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.6 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The MC3/4-R agonist MTII (0.6 nmol icv) activated PVN neurons.
    1 context sentence
    Summary · context
    In urethane-anesthetized rats, ipsilateral intracarotid artery (ICA) injection of murine leptin (100 microg/kg) activated most PVN neurons tested.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In anesthetized rats, intracerebroventricular MTII excited presympathetic rostral ventrolateral medulla neurons, mimicking the effect of leptin.

    In plain wordsIn anesthetized rats, MTII injected into the brain excited nerve cells in the brainstem, like leptin did.

    Peptide
    Melanotan II
    Outcome
    IncreasePresympathetic rostral ventrolateral medulla neuron activity
    Study

    ratn: not reported in source

    Urethane-anesthetized rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.6 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    ICA leptin (100 microg/kg) excited presympathetic rostral ventrolateral medulla neurons and renal sympathetic nerve activity without significant change in blood pressure or heart rate; these effects were mimicked by intracerebroventricular injection of MTII (0.6 nmol).
    1 context sentence
    Summary · context
    In urethane-anesthetized rats, ipsilateral intracarotid artery (ICA) injection of murine leptin (100 microg/kg) activated most PVN neurons tested.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In anesthetized rats, intracerebroventricular MTII increased renal sympathetic nerve activity, mimicking the effect of leptin.

    In plain wordsIn anesthetized rats, MTII injected into the brain raised kidney nerve activity, like leptin did.

    Peptide
    Melanotan II
    Outcome
    IncreaseRenal sympathetic nerve activity
    Study

    ratn: not reported in source

    Urethane-anesthetized rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.6 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    ICA leptin (100 microg/kg) excited presympathetic rostral ventrolateral medulla neurons and renal sympathetic nerve activity without significant change in blood pressure or heart rate; these effects were mimicked by intracerebroventricular injection of MTII (0.6 nmol).
    1 context sentence
    Summary · context
    In urethane-anesthetized rats, ipsilateral intracarotid artery (ICA) injection of murine leptin (100 microg/kg) activated most PVN neurons tested.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, intracerebroventricular MTII did not significantly change blood pressure, as with leptin.

    In plain wordsIn anesthetized rats, MTII injected into the brain did not significantly change blood pressure.

    Peptide
    Melanotan II
    Outcome
    No significant changeBlood pressure
    Study

    ratn: not reported in source

    Urethane-anesthetized rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    0.6 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    ICA leptin (100 microg/kg) excited presympathetic rostral ventrolateral medulla neurons and renal sympathetic nerve activity without significant change in blood pressure or heart rate; these effects were mimicked by intracerebroventricular injection of MTII (0.6 nmol).
    1 context sentence
    Summary · context
    In urethane-anesthetized rats, ipsilateral intracarotid artery (ICA) injection of murine leptin (100 microg/kg) activated most PVN neurons tested.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, intracerebroventricular MTII did not significantly change heart rate, as with leptin.

    In plain wordsIn anesthetized rats, MTII injected into the brain did not significantly change heart rate.

    Peptide
    Melanotan II
    Outcome
    No significant changeHeart rate
    Study

    ratn: not reported in source

    Urethane-anesthetized rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.6 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    ICA leptin (100 microg/kg) excited presympathetic rostral ventrolateral medulla neurons and renal sympathetic nerve activity without significant change in blood pressure or heart rate; these effects were mimicked by intracerebroventricular injection of MTII (0.6 nmol).
    1 context sentence
    Summary · context
    In urethane-anesthetized rats, ipsilateral intracarotid artery (ICA) injection of murine leptin (100 microg/kg) activated most PVN neurons tested.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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