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Study · Ex vivo tissue · chicken · 2003

2 results

Cyclic AMP formation in chicken brain: effect of vasoactive intestinal peptide, peptide histidine-isoleucine (PHI), and some PHI-related peptides.

Dejda A, Matczak I, Wiktorowska-Owczarek A, Nowak JZ

Polish journal of pharmacology1 Sept 2003

PMID14704471 (opens in a new tab)PepBankPUB-14704471
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In slices of chick hypothalamus and cerebral cortex, chicken VIP stimulated cAMP production in a concentration-dependent way at 0.1-3 µM.

    In plain wordsIn lab tests on chick brain slices, chicken VIP raised cAMP, a cell signal, in a dose-dependent way.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreasecAMP production in chick hypothalamus and cerebral cortex
    Study

    chickenn: not reported in source

    Slices of chick cerebral cortex and hypothalamus
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.1-3 microMAs given in this study (chicken).

    Source sentences

    Summary
    The chVIP (0.1-3 microM) concentration-dependently and potently stimulated cAMP production in HTh and CCx
    1 context sentence
    Summary · context
    Vasoactive intestinal peptide (chicken form; chVIP), peptide histidine-isoleucine (porcine and rat forms; pPHI and rPHI), D-Phe(4) derivative of porcine PHI (D-Phe(4)-pPHI), peptide histidine-methionine (PHM; human PHI), and helodermin, were tested for their ability to stimulate cAMP production in […
  2. 02LabEx vivo tissueActivity measurement

    In slices of chick brain, the cAMP response to 3 µM chicken VIP was comparable to that of 0.1 µM PACAP38.

    In plain wordsIn lab tests on chick brain slices, chicken VIP at 3 µM gave a cAMP response similar to PACAP38 at a lower dose.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changecAMP response to chicken VIP versus PACAP38
    Study

    chickenn: not reported in source

    Slices of chick cerebral cortex and hypothalamus
    Comparator
    0.1 microM PACAP38
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    3 microMAs given in this study (chicken).

    Source sentences

    Summary
    the responses observed after 3 microM of chVIP were comparable to those produced by 0.1 microM PACAP38
    1 context sentence
    Summary · context
    Vasoactive intestinal peptide (chicken form; chVIP), peptide histidine-isoleucine (porcine and rat forms; pPHI and rPHI), D-Phe(4) derivative of porcine PHI (D-Phe(4)-pPHI), peptide histidine-methionine (PHM; human PHI), and helodermin, were tested for their ability to stimulate cAMP production in […

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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