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Study · Animal study (in vivo) · mouse · 2004

12 results

Responsiveness to peripherally administered melanocortins in lean and obese mice.

Blüher S, Ziotopoulou M, Bullen JW Jr, Moschos SJ, Ungsunan L, Kokkotou E, Maratos-Flier E, Mantzoros CS

Diabetes1 Jan 2004Cited by 68 (Europe PMC)

PMID14693701 (opens in a new tab)DOI10.2337/diabetes.53.1.82 (opens in a new tab)PepBankPUB-14693701
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MTII for 24 h decreased food intake more strongly in diet-induced obese mice than in lean mice.

    In plain wordsIn mice, MTII cut food intake more in diet-induced obese mice than in lean mice after 24 hours.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake after 24 h
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Comparator
    Lean mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 24 hAs given in this study (mouse).

    Source sentences

    Summary
    MTII administration (100 microg q.i.d. i.p.) for 24 h results in similar weight loss but a more pronounced decrease of food intake in DIO mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, MTII for 24 h caused similar weight loss in diet-induced obese and lean mice.

    In plain wordsIn mice, MTII caused similar weight loss in diet-induced obese and lean mice after 24 hours.

    Peptide
    Melanotan II
    Outcome
    No significant changeBody weight loss after 24 h
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Comparator
    Lean mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 24 hAs given in this study (mouse).

    Source sentences

    Summary
    MTII administration (100 microg q.i.d. i.p.) for 24 h results in similar weight loss but a more pronounced decrease of food intake in DIO mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, after 4 and 8 days of MTII the reduction in food intake was more pronounced in diet-induced obese mice than in lean mice.

    In plain wordsIn mice, after 4 and 8 days MTII reduced food intake more in diet-induced obese mice than in lean mice.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake after 4 and 8 days
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Comparator
    Lean mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 4 and 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    After 4 and 8 days of MTII treatment, however, the reduction in both food intake and body weight is more pronounced in DIO mice than in lean mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, after 4 and 8 days of MTII the reduction in body weight was more pronounced in diet-induced obese mice than in lean mice.

    In plain wordsIn mice, after 4 and 8 days MTII reduced body weight more in diet-induced obese mice than in lean mice.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody weight after 4 and 8 days
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Comparator
    Lean mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 4 and 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    After 4 and 8 days of MTII treatment, however, the reduction in both food intake and body weight is more pronounced in DIO mice than in lean mice.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, 24 h of MTII prevented food deprivation-induced alterations in hypothalamic neuropeptide Y mRNA expression.

    In plain wordsIn mice, MTII prevented the changes in hypothalamic NPY gene activity that food deprivation causes.

    Peptide
    Melanotan II
    Outcome
    Direction not reportedHypothalamic NPY mRNA after food deprivation
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 24 hAs given in this study (mouse).

    Source sentences

    Summary
    MTII administration for 24 h prevents food deprivation-induced alterations in hypothalamic neuropeptide Y (NPY) and liver adiponectin receptor 1 and adiponectin receptor 2 mRNA expression, but does not alter hypothalamic mRNA expression of melanocortin 4 receptor or adiponectin serum and mRNA expression levels.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice, 24 h of MTII prevented food deprivation-induced alterations in liver adiponectin receptor 1 mRNA expression.

    In plain wordsIn mice, MTII prevented the changes in liver adiponectin receptor 1 gene activity that food deprivation causes.

    Peptide
    Melanotan II
    Outcome
    Direction not reportedLiver adiponectin receptor 1 mRNA after food deprivation
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 24 hAs given in this study (mouse).

    Source sentences

    Summary
    MTII administration for 24 h prevents food deprivation-induced alterations in hypothalamic neuropeptide Y (NPY) and liver adiponectin receptor 1 and adiponectin receptor 2 mRNA expression, but does not alter hypothalamic mRNA expression of melanocortin 4 receptor or adiponectin serum and mRNA expression levels.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice, 24 h of MTII prevented food deprivation-induced alterations in liver adiponectin receptor 2 mRNA expression.

    In plain wordsIn mice, MTII prevented the changes in liver adiponectin receptor 2 gene activity that food deprivation causes.

    Peptide
    Melanotan II
    Outcome
    Direction not reportedLiver adiponectin receptor 2 mRNA after food deprivation
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 24 hAs given in this study (mouse).

    Source sentences

    Summary
    MTII administration for 24 h prevents food deprivation-induced alterations in hypothalamic neuropeptide Y (NPY) and liver adiponectin receptor 1 and adiponectin receptor 2 mRNA expression, but does not alter hypothalamic mRNA expression of melanocortin 4 receptor or adiponectin serum and mRNA expression levels.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice, 24 h of MTII did not alter hypothalamic melanocortin 4 receptor mRNA expression.

    In plain wordsIn mice, MTII did not change hypothalamic melanocortin 4 receptor gene activity after 24 hours.

    Peptide
    Melanotan II
    Outcome
    No significant changeHypothalamic melanocortin 4 receptor mRNA
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 24 hAs given in this study (mouse).

    Source sentences

    Summary
    MTII administration for 24 h prevents food deprivation-induced alterations in hypothalamic neuropeptide Y (NPY) and liver adiponectin receptor 1 and adiponectin receptor 2 mRNA expression, but does not alter hypothalamic mRNA expression of melanocortin 4 receptor or adiponectin serum and mRNA expression levels.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice, 24 h of MTII did not alter serum adiponectin levels.

    In plain wordsIn mice, MTII did not change blood adiponectin levels after 24 hours.

    Peptide
    Melanotan II
    Outcome
    No significant changeSerum adiponectin
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 24 hAs given in this study (mouse).

    Source sentences

    Summary
    MTII administration for 24 h prevents food deprivation-induced alterations in hypothalamic neuropeptide Y (NPY) and liver adiponectin receptor 1 and adiponectin receptor 2 mRNA expression, but does not alter hypothalamic mRNA expression of melanocortin 4 receptor or adiponectin serum and mRNA expression levels.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mice, 24 h of MTII did not alter adiponectin mRNA expression.

    In plain wordsIn mice, MTII did not change adiponectin gene activity after 24 hours.

    Peptide
    Melanotan II
    Outcome
    No significant changeAdiponectin mRNA expression
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 24 hAs given in this study (mouse).

    Source sentences

    Summary
    MTII administration for 24 h prevents food deprivation-induced alterations in hypothalamic neuropeptide Y (NPY) and liver adiponectin receptor 1 and adiponectin receptor 2 mRNA expression, but does not alter hypothalamic mRNA expression of melanocortin 4 receptor or adiponectin serum and mRNA expression levels.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice, NPY mRNA expression after 8 days of MTII increased to levels comparable to pair-fed mice.

    In plain wordsIn mice, 8 days of MTII raised NPY gene activity to levels similar to food-restricted mice.

    Peptide
    Melanotan II
    Outcome
    IncreaseNPY mRNA after 8 days
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Comparator
    Pair-fed mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    NPY and agouti gene-related protein (AgRP) mRNA expression after 8 days of MTII is increased to levels comparable to pair-fed mice.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In mice, AgRP mRNA expression after 8 days of MTII increased to levels comparable to pair-fed mice.

    In plain wordsIn mice, 8 days of MTII raised AgRP gene activity to levels similar to food-restricted mice.

    Peptide
    Melanotan II
    Outcome
    IncreaseAgRP mRNA after 8 days
    Study

    mousen: not reported in source

    Lean C57BL/6J and obese (DIO, ob/ob, UCP1-DTA) mice
    Comparator
    Pair-fed mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    100 µg four times daily · intraperitoneal · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    NPY and agouti gene-related protein (AgRP) mRNA expression after 8 days of MTII is increased to levels comparable to pair-fed mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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