Acute decrease in circulating T3 levels enhances, but does not normalise, the GH response to GHRP-6 plus GHRH in thyrotoxicosis.

Nascif SO, Senger MH, Ramos-Dias JC, Lengyel AM

Journal of endocrinological investigation1 Aug 2003Cited by 2 (Europe PMC)

PMID14669827DOI10.1007/bf03347355PepBankPUB-14669827

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
In treated hyperthyroid patients, GH peaks after GHRP‑6 plus GHRH remained lower than in controls.
In plain wordsIn treated hyperthyroid patients, GH peaks after the combined test remained lower than in controls.
Peptide
GHRP-6
Outcome
DecreasePost-treatment GH peak versus controls
Study
n = 18
Comparator
Normal controls
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
Peak GH
18.3 microg/l
Treated hyperthyroid patients
Peak GH
83.7 microg/l
Normal controls
Source sentences
Summary
Despite the significant enhancement of the GH responsiveness to GHRP-6 plus GHRH after treatment with iopanoic acid, this response remained significantly blunted when compared to controls both in terms of peak GH (18.3 +/- 3.0 vs 83.7 +/- 15.2; p<0.05) and AUC values (1227.9 +/- 212.9 vs 4956.5 +/- 889.3; p<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
We have now studied the effect of a decrease in serum T3 levels on the GH response to GHRP-6 (1 microg/kg) plus GHRH (100 microg) in 9 hyperthyroid patients before and after 15 days of treatment with iopanoic acid (3 g every 3 days) and propylthiouracil (600 mg/day).
Summary · context
Nine normal subjects were also studied.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1466982703
02HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
In treated hyperthyroid patients, GH AUC after GHRP‑6 plus GHRH remained lower than in controls.
In plain wordsIn treated hyperthyroid patients, overall GH responses after the combined test remained lower than in controls.
Peptide
GHRP-6
Outcome
DecreasePost-treatment GH AUC versus controls
Study
n = 18
Comparator
Normal controls
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
1227.9 microg/l x 120 min
hyperthyroid patients on day 15 after iopanoic acid, mean (SE 212.9)
GH AUC
4956.5 microg/l x 120 min
normal controls, mean (SE 889.3)
Source sentences
Summary
Despite the significant enhancement of the GH responsiveness to GHRP-6 plus GHRH after treatment with iopanoic acid, this response remained significantly blunted when compared to controls both in terms of peak GH (18.3 +/- 3.0 vs 83.7 +/- 15.2; p<0.05) and AUC values (1227.9 +/- 212.9 vs 4956.5 +/- 889.3; p<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
We have now studied the effect of a decrease in serum T3 levels on the GH response to GHRP-6 (1 microg/kg) plus GHRH (100 microg) in 9 hyperthyroid patients before and after 15 days of treatment with iopanoic acid (3 g every 3 days) and propylthiouracil (600 mg/day).
Summary · context
Nine normal subjects were also studied.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1466982704
03HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
In hyperthyroid patients, GH peaks after GHRP‑6 plus GHRH rose after thyroid-directed treatment.
In plain wordsIn hyperthyroid patients, GH peaks after the combined test rose after treatment compared with pretreatment.
Peptide
GHRP-6
Outcome
IncreaseGH peak after treatment
Study
n = 9
Comparator
Pretreatment
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
Peak GH
18.3 microg/l
Day 15 of treatment
Peak GH
13.4 microg/l
Pretreatment
Source sentences
Summary
In these subjects peak GH (microg/l; mean +/- SE) and AUC (microg/l x 120 min) values after GHRP-6 plus GHRH were significantly higher on day 15 compared to pretreatment values (peak, 18.3 +/- 3.0 vs 13.4 +/- 1.9; AUC, 1227.9 +/- 212.9 vs 968.5 +/- 160.4; p<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
We have now studied the effect of a decrease in serum T3 levels on the GH response to GHRP-6 (1 microg/kg) plus GHRH (100 microg) in 9 hyperthyroid patients before and after 15 days of treatment with iopanoic acid (3 g every 3 days) and propylthiouracil (600 mg/day).
Summary · context
Nine normal subjects were also studied.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1466982701
04HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
In hyperthyroid patients, GH AUC after GHRP‑6 plus GHRH rose after thyroid-directed treatment.
In plain wordsIn hyperthyroid patients, overall GH responses after the combined test rose after treatment compared with pretreatment.
Peptide
GHRP-6
Outcome
IncreaseGH AUC after treatment
Study
n = 9
Comparator
Pretreatment
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
1227.9 microg/l x 120 min
Day 15 of treatment
GH AUC
968.5 microg/l x 120 min
Pretreatment
Source sentences
Summary
In these subjects peak GH (microg/l; mean +/- SE) and AUC (microg/l x 120 min) values after GHRP-6 plus GHRH were significantly higher on day 15 compared to pretreatment values (peak, 18.3 +/- 3.0 vs 13.4 +/- 1.9; AUC, 1227.9 +/- 212.9 vs 968.5 +/- 160.4; p<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
We have now studied the effect of a decrease in serum T3 levels on the GH response to GHRP-6 (1 microg/kg) plus GHRH (100 microg) in 9 hyperthyroid patients before and after 15 days of treatment with iopanoic acid (3 g every 3 days) and propylthiouracil (600 mg/day).
Summary · context
Nine normal subjects were also studied.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1466982702

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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