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Study · Animal study (in vivo) · rat · 2003

2 results

Electrophysiological effects of melanocortin receptor ligands on neuronal activities of monoaminergic neurons in rats.

Kawashima N, Chaki S, Okuyama S

Neuroscience letters1 Dec 2003Cited by 20 (Europe PMC)

PMID14664915 (opens in a new tab)DOI10.1016/j.neulet.2003.09.024 (opens in a new tab)PepBankPUB-14664915
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, intracerebroventricular MTII increased the firing rate of dorsal raphe nucleus serotonergic neurons.

    In plain wordsIn rats, melanotan II injected into the brain increased the firing rate of serotonin neurons in the dorsal raphe.

    Peptide
    Melanotan II
    Outcome
    IncreaseFiring rate of DRN serotonergic neurons
    Study

    ratn: not reported in source

    Rat dorsal raphe nucleus and locus coeruleus neurons
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The firing rate of DRN serotonergic neurons was increased by MTII
    1 context sentence
    Summary · context
    we examined effects of an intracerebroventricular injection of the MC4 receptor agonist, Ac-[Nle4,Asp5,D-Phe7,Lys10]-alpha-MSH 4-10-NH2 (MT II)
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, intracerebroventricular MTII significantly reduced the firing rate of locus coeruleus noradrenergic neurons.

    In plain wordsIn rats, melanotan II injected into the brain reduced the firing rate of noradrenaline neurons in the locus coeruleus.

    Peptide
    Melanotan II
    Outcome
    DecreaseFiring rate of LC noradrenergic neurons
    Study

    ratn: not reported in source

    Rat dorsal raphe nucleus and locus coeruleus neurons
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    In comparison with the DRN, MTII significantly reduced the firing rate of LC noradrenergic neurons
    1 context sentence
    Summary · context
    we examined effects of an intracerebroventricular injection of the MC4 receptor agonist, Ac-[Nle4,Asp5,D-Phe7,Lys10]-alpha-MSH 4-10-NH2 (MT II)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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