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Study · Animal study (in vivo) · mouse · 2003

1 result

Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test.

Bellasio S, Nicolussi E, Bertorelli R, Reggiani A

European journal of pharmacology1 Dec 2003Cited by 21 (Europe PMC)

PMID14660013 (opens in a new tab)DOI10.1016/j.ejphar.2003.09.017 (opens in a new tab)PepBankPUB-14660013
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intrathecal MTII 5 nmol significantly increased nociception in both phases of the formalin test.

    In plain wordsIn mice, melanotan II injected into the spinal canal increased pain behaviour in both phases of the formalin test.

    Peptide
    Melanotan II
    Outcome
    IncreaseNociception in the formalin test
    Study

    mousen: not reported in source

    Mouse formalin test
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    5 nmol · intrathecalAs given in this study (mouse).

    Source sentences

    Summary
    The intrathecal injection of the melanocortin receptor agonist MTII ([Ac-Nle(4),Asp(5),D-Phe(7),Lys(10)]cyclo-alpha-MSH-(4-10) amide) (5 nmol; P<0.05) significantly increased nociception in both phases of the formalin test
    1 context sentence
    Summary · context
    We investigated the effect of melanocortin receptor agonist and antagonists on nociceptive behaviour induced by formalin in the mouse.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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