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Study · Measured the body's own peptide · 2004

2 results

Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice.

Bielsky IF, Hu SB, Szegda KL, Westphal H, Young LJ

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology1 Mar 2004Cited by 395 (Europe PMC)

PMID14647484 (opens in a new tab)DOI10.1038/sj.npp.1300360 (opens in a new tab)PepBankPUB-14647484
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In male mice lacking the V1a receptor, the body's own oxytocin mRNA levels were similar to wild-type mice.

    In plain wordsIn male mice lacking the V1a receptor, the body's own oxytocin mRNA levels were similar to normal mice.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin mRNA level
    Study

    mousen: not reported in source

    Comparator
    Wild-type mice
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    AVP and oxytocin (OT) mRNA and OT receptor-binding levels were similar in WT and V1aRKO mice.
    1 context sentence
    Summary · context
    Here we report the behavioral effects of a null mutation in the V1a receptor (V1aR) in male mice.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other

    In male mice lacking the V1a receptor, oxytocin receptor binding levels were similar to wild-type mice.

    In plain wordsIn male mice lacking the V1a receptor, oxytocin receptor levels were similar to normal mice.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin receptor binding
    Study

    mousen: not reported in source

    Comparator
    Wild-type mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    AVP and oxytocin (OT) mRNA and OT receptor-binding levels were similar in WT and V1aRKO mice.
    1 context sentence
    Summary · context
    Here we report the behavioral effects of a null mutation in the V1a receptor (V1aR) in male mice.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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