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Study · In vitro (cells) · 2003

3 results

Peptide Epitalon activates chromatin at the old age.

Khavinson VKh, Lezhava TA, Monaselidze JR, Jokhadze TA, Dvalishvili NA, Bablishvili NK, Trofimova SV

Neuro endocrinology letters1 Oct 2003Cited by 10 (Europe PMC)

PMID14647006 (opens in a new tab)PepBankPUB-14647006
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured lymphocytes of elderly persons, epitalon activated ribosomal genes.

    In plain wordsIn lab-grown cells from elderly donors, epitalon switched on ribosomal genes.

    Peptide
    Epitalon
    Outcome
    IncreaseRibosomal gene activity
    Study

    humann: not reported in source

    cultured lymphocytes of persons aged 76-80 years
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epitalon induces the activation of ribosomal genes
    1 context sentence
    Summary · context
    We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturation parameters of total heterochromatin, polymorphism of structural C-heterochromatin and the variability of facultative heterochromatin in cultured lymphocytes of persons aged 76-80 years.
  2. 02LabIn vitro (cells)Mechanism

    In cultured lymphocytes of elderly persons, epitalon decondensed pericentromeric structural heterochromatin.

    In plain wordsIn lab-grown cells from elderly donors, epitalon loosened packed chromatin near the centre of chromosomes.

    Peptide
    Epitalon
    Outcome
    DecreasePericentromeric structural heterochromatin condensation
    Study

    humann: not reported in source

    cultured lymphocytes of persons aged 76-80 years
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epitalon induces the activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin
    1 context sentence
    Summary · context
    We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturation parameters of total heterochromatin, polymorphism of structural C-heterochromatin and the variability of facultative heterochromatin in cultured lymphocytes of persons aged 76-80 years.
  3. 03LabIn vitro (cells)Mechanism

    In cultured lymphocytes of elderly persons, epitalon released genes repressed by age-related condensation of euchromatic chromosome regions.

    In plain wordsIn lab-grown cells from elderly donors, epitalon released genes that age-related chromatin packing had switched off.

    Peptide
    Epitalon
    Outcome
    IncreaseRelease of genes repressed by age-related euchromatin condensation
    Study

    humann: not reported in source

    cultured lymphocytes of persons aged 76-80 years
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epitalon induces the activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin and the release of genes repressed due to the age-related condensation of euchromatic chromosome regions.
    1 context sentence
    Summary · context
    We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturation parameters of total heterochromatin, polymorphism of structural C-heterochromatin and the variability of facultative heterochromatin in cultured lymphocytes of persons aged 76-80 years.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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