Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin.

Blevins JE, Eakin TJ, Murphy JA, Schwartz MW, Baskin DG

Brain research1 Dec 2003Cited by 131 (Europe PMC)

PMID14642828DOI10.1016/j.brainres.2003.08.036PepBankPUB-14642828

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In rats, the medial and gelatinosus subdivisions of the nucleus tractus solitarius, where CCK increased Fos, received dense innervation by oxytocin axons.
In plain wordsIn rats, brain areas that respond to the meal signal CCK contained many of the body's own oxytocin nerve fibers.
Peptide
Oxytocin
Outcome
Not applicableOxytocin axon innervation of medial and gelatinosus NTS
Study
ratn: not reported in source
rats
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
These same regions received dense oxytocin axon innervation, whereas CRH immunoreactivity was not as prevalent in these areas.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats received injections of either an anorexic dose of CCK (8 nmol/kg, i.p.) or vehicle and were perfused 2 h later with 4% paraformaldehyde.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1464282801
02AnimalEndogenous levelAnimal study (in vivo)Other
In rats, the dorsal motor nucleus of the vagus had dense oxytocin innervation but showed no Fos activation after CCK.
In plain wordsIn rats, one brain area had many of the body's own oxytocin fibers but showed no activity marker after CCK.
Peptide
Oxytocin
Outcome
Not applicableOxytocin innervation of the dorsal motor nucleus of the vagus
Study
ratn: not reported in source
rats
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
In areas outside the NTS, such as the dorsal motor nucleus of the vagus (DMV), Fos activation was absent despite a dense oxytocin and CRH innervation.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats received injections of either an anorexic dose of CCK (8 nmol/kg, i.p.) or vehicle and were perfused 2 h later with 4% paraformaldehyde.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1464282802

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In rats, CCK was 23% less effective at inhibiting food intake at 30 min after a fourth-ventricle oxytocin receptor antagonist (OVT).
In plain wordsIn rats, blocking oxytocin receptors made CCK 23% less able to reduce food intake at 30 minutes.
Peptide
Oxytocin
Outcome
DecreaseCCK inhibition of food intake at 30 min after oxytocin receptor antagonist
Study
ratn: not reported in source
rats
Outcome group
Appetite and food intake · Metabolic and weight
Measurements
Reduction of CCK effect on food intake at 30 min
23%
with OVT
Source sentences
Summary
This study showed CCK was 23% and 22% less effective at inhibiting food intake at 30 min (p<0.05) and 1 h (p<0.05) food intake, respectively, in the presence of OVT.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate whether CCK-induced reductions of food intake require intact oxytocin signaling, we performed a separate study in which CCK injection was preceded by injection into the fourth ventricle of an oxytocin receptor antagonist [d(CH(2))(5), Tyr (Me)(2), Orn(8)]-vasotocin (OVT).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1464282803
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In rats, CCK was 22% less effective at inhibiting food intake at 1 h after a fourth-ventricle oxytocin receptor antagonist (OVT).
In plain wordsIn rats, blocking oxytocin receptors made CCK 22% less able to reduce food intake at one hour.
Peptide
Oxytocin
Outcome
DecreaseCCK inhibition of food intake at 1 h after oxytocin receptor antagonist
Study
ratn: not reported in source
rats
Outcome group
Appetite and food intake · Metabolic and weight
Measurements
Reduction of CCK effect on food intake at 1 h
22%
with OVT
Source sentences
Summary
This study showed CCK was 23% and 22% less effective at inhibiting food intake at 30 min (p<0.05) and 1 h (p<0.05) food intake, respectively, in the presence of OVT.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate whether CCK-induced reductions of food intake require intact oxytocin signaling, we performed a separate study in which CCK injection was preceded by injection into the fourth ventricle of an oxytocin receptor antagonist [d(CH(2))(5), Tyr (Me)(2), Orn(8)]-vasotocin (OVT).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1464282804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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