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Study · Not a test of the peptide alone · 2003

1 result

Adrenalectomy alters the sensitivity of the central nervous system melanocortin system.

Drazen DL, Wortman MD, Schwartz MW, Clegg DJ, van Dijk G, Woods SC, Seeley RJ

Diabetes1 Dec 2003Cited by 32 (Europe PMC)

PMID14633853 (opens in a new tab)DOI10.2337/diabetes.52.12.2928 (opens in a new tab)PepBankPUB-14633853
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 01AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Efficacy outcome

    In rats, adrenalectomy enhanced the food-intake-reducing response to melanotan II through a glucocorticoid-dependent mechanism.

    In plain wordsIn rats, removing the adrenal glands made melanotan II reduce eating more strongly, and a steroid hormone was needed for this.

    Peptide
    Melanotan II
    Outcome
    IncreaseHypophagic response to melanotan II in adrenalectomized rats
    Study

    ratn: not reported in source

    adrenalectomized (ADX) rats
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Next we tested rats for their sensitivity to the melanocortin agonist melanotan II and found that, as for leptin, ADX enhanced the hypophagic response via a glucocorticoid-dependent mechanism.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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