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Study · Animal study (in vivo) · mouse · 2003

6 results

The neuroprotective effects of Cerebrolysin in a transgenic model of Alzheimer's disease are associated with improved behavioral performance.

Rockenstein E, Adame A, Mante M, Moessler H, Windisch M, Masliah E

Journal of neural transmission (Vienna, Austria : 1996)1 Nov 2003Cited by 59 (Europe PMC)

PMID14628195 (opens in a new tab)DOI10.1007/s00702-003-0025-7 (opens in a new tab)PepBankPUB-14628195
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In younger APP transgenic mice, Cerebrolysin significantly improved water maze performance versus saline.

    In plain wordsIn younger transgenic mice, Cerebrolysin improved maze performance compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseWater maze performance in younger cohort
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    Performance analysis in the water maze showed that in the younger tg mice cohort, Cerebrolysin treatment significantly ameliorated the performance deficits.
    1 context sentence
    Summary · context
    transgenic (tg) mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cerebrolysin or saline alone starting at 3 or 6 months of age for a total of three months.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In older APP transgenic mice, Cerebrolysin showed a trend toward improved learning-curve performance versus saline.

    In plain wordsIn older transgenic mice, Cerebrolysin showed a trend toward better learning performance compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseLearning curve in older cohort
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    In the older cohort, there was a trend toward improved performance in the learning curve.
    1 context sentence
    Summary · context
    transgenic (tg) mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cerebrolysin or saline alone starting at 3 or 6 months of age for a total of three months.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In both age groups of APP transgenic mice, Cerebrolysin promoted synaptic regeneration versus saline.

    In plain wordsIn transgenic mice of both age groups, Cerebrolysin increased synapse regeneration compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSynaptic regeneration
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    Neuropathological examination showed that in both age/treatment groups, Cerebrolysin promoted synaptic regeneration, and reduced the proportion of neurons displaying DNA fragmentation by the (TdT)-mediated dUTP-biotin nick-end labeling (TUNEL) method.
    1 context sentence
    Summary · context
    transgenic (tg) mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cerebrolysin or saline alone starting at 3 or 6 months of age for a total of three months.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In both age groups of APP transgenic mice, Cerebrolysin reduced the proportion of neurons with DNA fragmentation versus saline.

    In plain wordsIn transgenic mice of both age groups, Cerebrolysin reduced neurons with fragmented DNA compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseNeuronal DNA fragmentation
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    Neuropathological examination showed that in both age/treatment groups, Cerebrolysin promoted synaptic regeneration, and reduced the proportion of neurons displaying DNA fragmentation by the (TdT)-mediated dUTP-biotin nick-end labeling (TUNEL) method.
    1 context sentence
    Summary · context
    transgenic (tg) mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cerebrolysin or saline alone starting at 3 or 6 months of age for a total of three months.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In young APP transgenic mice, Cerebrolysin reduced amyloid beta burden by 43% versus saline.

    In plain wordsIn young transgenic mice, Cerebrolysin reduced amyloid burden by 43% compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAmyloid burden in young cohort
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Measurements

    Amyloid burden reduction
    43%
    young group

    Source sentences

    Summary
    Moreover, Cerebrolysin treatment reduced A beta burden by 43% in the young group and by 27% in the older group.
    1 context sentence
    Summary · context
    transgenic (tg) mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cerebrolysin or saline alone starting at 3 or 6 months of age for a total of three months.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In older APP transgenic mice, Cerebrolysin reduced amyloid beta burden by 27% versus saline.

    In plain wordsIn older transgenic mice, Cerebrolysin reduced amyloid burden by 27% compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAmyloid burden in older cohort
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Measurements

    Amyloid burden reduction
    27%
    older group

    Source sentences

    Summary
    Moreover, Cerebrolysin treatment reduced A beta burden by 43% in the young group and by 27% in the older group.
    1 context sentence
    Summary · context
    transgenic (tg) mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cerebrolysin or saline alone starting at 3 or 6 months of age for a total of three months.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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