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Study · Animal study (in vivo) · prairie vole (microtus ochrogaster) · 2003

3 results

Sex differences and developmental effects of oxytocin on aggression and social behavior in prairie voles (Microtus ochrogaster).

Bales KL, Carter CS

Hormones and behavior1 Sept 2003Cited by 140 (Europe PMC)

PMID14609540 (opens in a new tab)DOI10.1016/s0018-506x(03)00154-5 (opens in a new tab)PepBankPUB-14609540
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult prairie voles, neonatal oxytocin treatment caused no significant treatment differences in aggression within either sex before exposure to an animal of the opposite sex.

    In plain wordsIn adult prairie voles, oxytocin given at birth made no difference to behavior before they met an animal of the opposite sex.

    Peptide
    Oxytocin
    Outcome
    No significant changeIntrasexual aggression in Test 1 (before exposure to opposite sex)
    Study

    prairie vole (Microtus ochrogaster)n: not reported in source

    prairie voles injected within 24 h of birth
    Comparator
    oxytocin antagonist or control groups
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No significant treatment differences were observed within either sex in Test 1.
    1 context sentence
    Summary · context
    Within 24 h of birth, infants were randomly assigned to receive either an injection of oxytocin (OT) or oxytocin antagonist (OTA) or to one of two control (CTL) groups receiving either isotonic saline or handling without injection.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult female prairie voles, neonatal oxytocin treatment made females more aggressive after brief exposure to a male than antagonist-treated or control females.

    In plain wordsIn female prairie voles, oxytocin given at birth made them more aggressive after meeting a male, compared with antagonist or control females.

    Peptide
    Oxytocin
    Outcome
    IncreaseAggression in Test 2 in females after exposure to a male
    Study

    prairie vole (Microtus ochrogaster)n: not reported in source

    prairie voles injected within 24 h of birth
    Comparator
    oxytocin antagonist or control groups
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In Test 2, after brief exposure to a male, females treated with OT became more aggressive and less social than OTA or CTL females.
    1 context sentence
    Summary · context
    Within 24 h of birth, infants were randomly assigned to receive either an injection of oxytocin (OT) or oxytocin antagonist (OTA) or to one of two control (CTL) groups receiving either isotonic saline or handling without injection.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult female prairie voles, neonatal oxytocin treatment made females less social after brief exposure to a male than antagonist-treated or control females.

    In plain wordsIn female prairie voles, oxytocin given at birth made them less social after meeting a male, compared with antagonist or control females.

    Peptide
    Oxytocin
    Outcome
    DecreaseSocial behavior in Test 2 in females after exposure to a male
    Study

    prairie vole (Microtus ochrogaster)n: not reported in source

    prairie voles injected within 24 h of birth
    Comparator
    oxytocin antagonist or control groups
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In Test 2, after brief exposure to a male, females treated with OT became more aggressive and less social than OTA or CTL females.
    1 context sentence
    Summary · context
    Within 24 h of birth, infants were randomly assigned to receive either an injection of oxytocin (OT) or oxytocin antagonist (OTA) or to one of two control (CTL) groups receiving either isotonic saline or handling without injection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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