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Study · In vitro (cells) · mouse · 2003

5 results

Suppressor mechanism of serum thymic factor on tumor necrosis factor-alpha-induced apoptosis in the mouse pancreatic beta-cell line.

Yasuda J, Nishioka W, Sakudo A, Yama S, Setoguchi R, Saeki K, Matsumoto Y, Awaya A, Onodera T

Biochemical and biophysical research communications1 Nov 2003Cited by 5 (Europe PMC)

PMID14592444 (opens in a new tab)DOI10.1016/j.bbrc.2003.10.025 (opens in a new tab)PepBankPUB-14592444
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In MIN6 cells, FTS reduced TNF-alpha-induced DNA fragmentation at 1 ng/ml.

    In plain wordsIn cells, FTS reduced DNA fragmentation compared with TNF-alpha alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseDNA fragmentation
    Study

    mousen: not reported in source

    TNF-alpha-treated MIN6 pancreatic beta cells
    Comparator
    TNF-alpha without FTS
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    1 ng/mlAs given in this study (mouse).

    Measurements

    FTS concentration
    1 ng/ml
    Reduced DNA fragmentation

    Source sentences

    Summary
    The data indicate a distinct reduction of fragmented DNA at a concentration of 1 ng/ml FTS.
    2 context sentences
    Summary · context
    In this study, the effect of TNF-alpha on the murine pancreatic beta-cell line MIN6 was examined.
    Summary · context
    FTS was treated with TNF-alpha and the percentage of fragmented DNA was analyzed.
  2. 02LabIn vitro (cells)Mechanism

    In TNF-alpha-treated MIN6 cells, FTS suppressed iNOS mRNA expression.

    In plain wordsIn cells, FTS reduced iNOS gene activity compared with TNF-alpha alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseiNOS mRNA
    Study

    mousen: not reported in source

    TNF-alpha-treated MIN6 pancreatic beta cells
    Comparator
    TNF-alpha without FTS
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    FTS treatment suppressed the expression of iNOS and Bcl-2 mRNA in TNF-alpha-treated cells.
    2 context sentences
    Summary · context
    In this study, the effect of TNF-alpha on the murine pancreatic beta-cell line MIN6 was examined.
    Summary · context
    FTS was treated with TNF-alpha and the percentage of fragmented DNA was analyzed.
  3. 03LabIn vitro (cells)Mechanism

    In TNF-alpha-treated MIN6 cells, FTS suppressed Bcl-2 mRNA expression.

    In plain wordsIn cells, FTS reduced Bcl-2 gene activity compared with TNF-alpha alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseBcl-2 mRNA
    Study

    mousen: not reported in source

    TNF-alpha-treated MIN6 pancreatic beta cells
    Comparator
    TNF-alpha without FTS
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    FTS treatment suppressed the expression of iNOS and Bcl-2 mRNA in TNF-alpha-treated cells.
    2 context sentences
    Summary · context
    In this study, the effect of TNF-alpha on the murine pancreatic beta-cell line MIN6 was examined.
    Summary · context
    FTS was treated with TNF-alpha and the percentage of fragmented DNA was analyzed.
  4. 04LabIn vitro (cells)Mechanism

    In TNF-alpha-treated MIN6 cells, FTS enhanced NF-kappa B mRNA expression.

    In plain wordsIn cells, FTS increased NF-kappa B gene activity compared with TNF-alpha alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseNF-kappa B mRNA
    Study

    mousen: not reported in source

    TNF-alpha-treated MIN6 pancreatic beta cells
    Comparator
    TNF-alpha without FTS
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression of NF-kappa B mRNA in TNF-alpha-treated cells was enhanced after FTS treatment, while that of ICE mRNA did not change in TNF-alpha-treated cells with or without FTS treatment.
    2 context sentences
    Summary · context
    In this study, the effect of TNF-alpha on the murine pancreatic beta-cell line MIN6 was examined.
    Summary · context
    FTS was treated with TNF-alpha and the percentage of fragmented DNA was analyzed.
  5. 05LabIn vitro (cells)Mechanism

    In TNF-alpha-treated MIN6 cells, ICE mRNA expression did not change with FTS treatment.

    In plain wordsIn cells, FTS did not change ICE gene activity compared with TNF-alpha alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeICE mRNA
    Study

    mousen: not reported in source

    TNF-alpha-treated MIN6 pancreatic beta cells
    Comparator
    TNF-alpha without FTS
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression of NF-kappa B mRNA in TNF-alpha-treated cells was enhanced after FTS treatment, while that of ICE mRNA did not change in TNF-alpha-treated cells with or without FTS treatment.
    2 context sentences
    Summary · context
    In this study, the effect of TNF-alpha on the murine pancreatic beta-cell line MIN6 was examined.
    Summary · context
    FTS was treated with TNF-alpha and the percentage of fragmented DNA was analyzed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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