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Study · Animal study (in vivo) · rat · 2003

3 results

Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injection.

Safieh-Garabedian B, Ochoa-Chaar CI, Poole S, Massaad CA, Atweh SF, Jabbur SJ, Saadé NE

Neuroscience1 Jan 2003Cited by 17 (Europe PMC)

PMID14580936 (opens in a new tab)DOI10.1016/s0306-4522(03)00500-1 (opens in a new tab)PepBankPUB-14580936
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, intracerebroventricular thymulin at different doses had no significant effect on pain-related behavior.

    In plain wordsIn rats, intracerebroventricular thymulin had no significant effect on pain-related behavior.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changePain-related behavior without endotoxin
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    However, thymulin at different doses, when injected (i.c.v.), had no significant effect on pain related behavior.
    1 context sentence
    Summary · context
    In this study, we have examined the effect of i.c.v. injections of either endotoxin (ET) or thymulin, in separate groups of conscious rats, on pain-related behavior and cytokine levels in different areas of the brain.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular thymulin before endotoxin reduced hyperalgesia in a dose-dependent manner.

    In plain wordsIn rats, thymulin before intracerebroventricular endotoxin reduced hyperalgesia in a dose-dependent manner.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseEndotoxin-induced hyperalgesia
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.1, 0.5 and 1 microg in 5 microl saline · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment (i.c.v.) with thymulin (0.1, 0.5 and 1 microg in 5 microl saline) 20 min before endotoxin (i.c.v.) injection (1 microg in 5 microl saline) reduced, in a dose dependent manner, the endotoxin-induced hyperalgesia
    1 context sentence
    Summary · context
    In this study, we have examined the effect of i.c.v. injections of either endotoxin (ET) or thymulin, in separate groups of conscious rats, on pain-related behavior and cytokine levels in different areas of the brain.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, intracerebroventricular thymulin before endotoxin had differential effects on upregulated cytokines across brain areas.

    In plain wordsIn rats, thymulin before intracerebroventricular endotoxin had different effects on raised cytokine levels across brain areas.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    MixedBrain cytokine upregulation
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    0.1, 0.5 and 1 microg in 5 microl saline · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment (i.c.v.) with thymulin (0.1, 0.5 and 1 microg in 5 microl saline) 20 min before endotoxin (i.c.v.) injection (1 microg in 5 microl saline) reduced, in a dose dependent manner, the endotoxin-induced hyperalgesia and exerted differential effects on the up-regulated levels of cytokines in…
    1 context sentence
    Summary · context
    In this study, we have examined the effect of i.c.v. injections of either endotoxin (ET) or thymulin, in separate groups of conscious rats, on pain-related behavior and cytokine levels in different areas of the brain.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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