Skip to content

Study · Animal study (in vivo) · rat · 2003

3 results

Learned meal initiation attenuates the anorexic effects of the melanocortin agonist MTII.

Benoit SC, Clegg DJ, Barrera JG, Seeley RJ, Woods SC

Diabetes1 Nov 2003Cited by 21 (Europe PMC)

PMID14578286 (opens in a new tab)DOI10.2337/diabetes.52.11.2684 (opens in a new tab)PepBankPUB-14578286
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, long-term maintenance on a meal-feeding schedule attenuated the response to central MTII.

    In plain wordsIn rats, long-term meal feeding on a schedule made the food-reducing effect of melanotan II weaker.

    Peptide
    Melanotan II
    Outcome
    DecreaseMTII-induced anorexia after long-term meal feeding
    Study

    ratn: not reported in source

    Rats on meal-feeding schedules
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · central administrationAs given in this study (rat).

    Source sentences

    Summary
    In the first experiment, we identified that long-term maintenance on a meal-feeding schedule attenuated rats' sensitivity to central administration of the melanocortin agonist MTII.
    1 context sentence
    Summary · context
    An important unanswered question has been whether melanocortin agonists would also reduce food intake that is driven by factors other than homeostatic mechanisms (e.g., conditioned eating).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the attenuated MTII-induced anorexia was due to learned schedules of food intake rather than food deprivation per se.

    In plain wordsIn rats, the weaker food-reducing effect of melanotan II came from learned eating schedules, not from going without food.

    Peptide
    Melanotan II
    Outcome
    DecreaseCause of attenuated MTII anorexia (learned schedule versus food deprivation)
    Study

    ratn: not reported in source

    Rats on meal-feeding schedules
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · central administrationAs given in this study (rat).

    Source sentences

    Summary
    The results from a second experiment demonstrate that the attenuation of the MTII-induced anorexia was due to learned schedules of food intake rather than food deprivation per se.
    1 context sentence
    Summary · context
    An important unanswered question has been whether melanocortin agonists would also reduce food intake that is driven by factors other than homeostatic mechanisms (e.g., conditioned eating).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the attenuation of MTII-induced anorexia may be independent of the decreased sensitivity caused by a high-fat diet.

    In plain wordsIn rats, the weaker effect of melanotan II on eating may not depend on the lower sensitivity caused by a high-fat diet.

    Peptide
    Melanotan II
    Outcome
    Not applicableMTII-induced anorexia with a high-fat diet
    Study

    ratn: not reported in source

    Rats on meal-feeding schedules
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · central administrationAs given in this study (rat).

    Source sentences

    Summary
    Results from the final experiment suggest that this attenuation of MTII-induced anorexia may be independent of the decreased sensitivity caused by a high-fat diet.
    1 context sentence
    Summary · context
    An important unanswered question has been whether melanocortin agonists would also reduce food intake that is driven by factors other than homeostatic mechanisms (e.g., conditioned eating).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.