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Study · Animal study (in vivo) · rat · 2003

1 result

Interrelationships between mu opioid and melanocortin receptors in mediating food intake in rats.

Grossman HC, Hadjimarkou MM, Silva RM, Giraudo SQ, Bodnar RJ

Brain research1 Nov 2003Cited by 36 (Europe PMC)

PMID14575897 (opens in a new tab)DOI10.1016/s0006-8993(03)03442-5 (opens in a new tab)PepBankPUB-14575897
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, pretreatment with intracerebroventricular melanotan II significantly and dose-dependently reduced feeding induced by beta-endorphin.

    In plain wordsIn rats, melanotan II given into the brain reduced the eating that beta-endorphin caused, more so at higher doses.

    Peptide
    Melanotan II
    Outcome
    DecreaseBeta-endorphin-induced feeding
    Study

    ratn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.01-10 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Feeding induced by the mu-sensitive opioid peptide, beta-endorphin (betaEND, 10 microg, i.c.v.) was significantly and dose-dependently reduced by pretreatment with the MC-3/4 receptor agonist, melanotan-II (MTII: 0.01-10 nmol, i.c.v.).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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