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Study · Animal study (in vivo) · rat (sprague-dawley) · 2003

3 results

Early exposure to oxytocin affects the age of vaginal opening and first estrus in female rats.

Withuhn TF, Kramer KM, Cushing BS

Physiology & behavior1 Oct 2003Cited by 17 (Europe PMC)

PMID14568318 (opens in a new tab)DOI10.1016/s0031-9384(03)00222-1 (opens in a new tab)PepBankPUB-14568318
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, neonatal oxytocin treatment significantly delayed the age of vaginal opening.

    In plain wordsIn female rats, oxytocin given just after birth delayed the age at which the vagina opened.

    Peptide
    Oxytocin
    Outcome
    IncreaseAge of vaginal opening
    Study

    rat (Sprague-Dawley)n: not reported in source

    female Sprague-Dawley rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mug/g · intraperitoneal · from the day of birth for the next 6 daysAs given in this study (rat (Sprague-Dawley)).

    Source sentences

    Summary
    Treatment with OT significantly delayed the age of vaginal opening
    2 context sentences
    Summary · context
    To test this hypothesis, female Sprague-Dawley rats received one of four treatments beginning on the day of birth and continuing for the next 6 days.
    Summary · context
    Three groups received an intraperitoneal injection of one of the following: OT (1 mug/g), an OT antagonist (OTA, 0.1 mug/g) or isotonic saline (vehicle control).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, neonatal oxytocin treatment significantly delayed the onset of first estrus.

    In plain wordsIn female rats, oxytocin given just after birth delayed the first estrus.

    Peptide
    Oxytocin
    Outcome
    IncreaseAge at onset of first estrus
    Study

    rat (Sprague-Dawley)n: not reported in source

    female Sprague-Dawley rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mug/g · intraperitoneal · from the day of birth for the next 6 daysAs given in this study (rat (Sprague-Dawley)).

    Source sentences

    Summary
    Treatment with OT significantly delayed the age of vaginal opening and the onset of first estrus.
    2 context sentences
    Summary · context
    To test this hypothesis, female Sprague-Dawley rats received one of four treatments beginning on the day of birth and continuing for the next 6 days.
    Summary · context
    Three groups received an intraperitoneal injection of one of the following: OT (1 mug/g), an OT antagonist (OTA, 0.1 mug/g) or isotonic saline (vehicle control).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, neonatal oxytocin treatment had no effect on body weight.

    In plain wordsIn female rats, oxytocin given just after birth did not change body weight.

    Peptide
    Oxytocin
    Outcome
    No significant changeBody weight
    Study

    rat (Sprague-Dawley)n: not reported in source

    female Sprague-Dawley rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1 mug/g · intraperitoneal · from the day of birth for the next 6 daysAs given in this study (rat (Sprague-Dawley)).

    Source sentences

    Summary
    There was no effect on weight.
    3 context sentences
    Summary · context
    The potential effects of OT on body weight were also measured, with females being weighed on postnatal days 1-7, 70, 91 and 136.
    Summary · context
    To test this hypothesis, female Sprague-Dawley rats received one of four treatments beginning on the day of birth and continuing for the next 6 days.
    Summary · context
    Three groups received an intraperitoneal injection of one of the following: OT (1 mug/g), an OT antagonist (OTA, 0.1 mug/g) or isotonic saline (vehicle control).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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