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Study · Not a test of the peptide alone · 2003

4 results

Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles.

Liu Y, Wang ZX

Neuroscience1 Jan 2003Cited by 414 (Europe PMC)

PMID14568015 (opens in a new tab)DOI10.1016/s0306-4522(03)00555-4 (opens in a new tab)PepBankPUB-14568015
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In female prairie voles, blocking oxytocin receptors or D2-type dopamine receptors prevented the partner preferences that oxytocin induced.

    In plain wordsIn female prairie voles, blocking oxytocin or D2-type dopamine receptors stopped partner preferences that oxytocin caused.

    Peptide
    Oxytocin
    Outcome
    DecreaseOT-induced partner preference after OT receptor or D2-type receptor blockade
    Study

    prairie vole (Microtus ochrogaster)n: not reported in source

    female prairie voles
    Outcome group
    Social behavior and cognition · Nervous system and cognition

    Source sentences

    Summary
    Here, we demonstrated that access to both OT and DA D2-type receptors is necessary for pair bond formation, as blockade of either type of receptor prevented partner preferences induced by OT or a D2-type agonist.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In the nucleus accumbens of female prairie voles, blocking oxytocin receptors prevented partner preferences induced by a D2-type agonist.

    In plain wordsIn female prairie voles, blocking oxytocin receptors in one brain area stopped partner preferences caused by a dopamine-type drug.

    Peptide
    Oxytocin
    Outcome
    DecreaseD2-type agonist-induced partner preference after OT receptor blockade in NAcc
    Study

    prairie vole (Microtus ochrogaster)n: not reported in source

    female prairie voles
    Outcome group
    Social behavior and cognition · Nervous system and cognition

    Source sentences

    Summary
    In NAcc, blockade of OT receptors prevented partner preferences induced by a D2-type agonist

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In the nucleus accumbens of female prairie voles, blocking D2-type dopamine receptors blocked partner preferences induced by oxytocin.

    In plain wordsIn female prairie voles, blocking D2-type dopamine receptors in one brain area stopped partner preferences that oxytocin caused.

    Peptide
    Oxytocin
    Outcome
    DecreaseOT-induced partner preference after D2-type receptor blockade in NAcc
    Study

    prairie vole (Microtus ochrogaster)n: not reported in source

    female prairie voles
    Outcome group
    Social behavior and cognition · Nervous system and cognition

    Source sentences

    Summary
    blockade of D2-type, but not D1-type, DA receptors blocked OT-induced partner preferences

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In the nucleus accumbens of female prairie voles, blocking D1-type dopamine receptors did not block partner preferences induced by oxytocin.

    In plain wordsIn female prairie voles, blocking D1-type dopamine receptors did not stop partner preferences that oxytocin caused.

    Peptide
    Oxytocin
    Outcome
    No significant changeOT-induced partner preference after D1-type receptor blockade in NAcc
    Study

    prairie vole (Microtus ochrogaster)n: not reported in source

    female prairie voles
    Outcome group
    Social behavior and cognition · Nervous system and cognition

    Source sentences

    Summary
    blockade of D2-type, but not D1-type, DA receptors blocked OT-induced partner preferences

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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