The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men.

Hameed M, Lange KH, Andersen JL, Schjerling P, Kjaer M, Harridge SD, Goldspink G

The Journal of physiology17 Oct 2003Cited by 118 (Europe PMC)

PMID14565994DOI10.1113/jphysiol.2003.051722PepBankPUB-14565994

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. 3 results from people.

01HumanNon-randomized trialMechanism
In healthy elderly men, GH alone did not change muscle MGF mRNA at 5 weeks versus baseline.
In plain wordsIn elderly men, GH alone did not change muscle MGF mRNA at 5 weeks versus baseline.
Peptide
HGH (somatotropin)
Outcome
No significant changeMGF mRNA at 5 weeks
Study
n: not reported in source
Comparator
Baseline
Outcome group
Growth hormone and IGF-1 · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
GH administration did not change MGF mRNA at 5 weeks, but significantly increased IGF-IEa mRNA (237%).
3 context sentences(design, population, supporting numbers)
Summary · context
The expression of two isoforms of insulin-like growth factor-I (IGF-I): mechano growth factor (MGF) and IGF-IEa were studied in muscle in response to growth hormone (GH) administration with and without resistance training in healthy elderly men.
Summary · context
The subjects (age 74 +/- 1 years, mean +/- S.E.M) were assigned to either resistance training with placebo, resistance training combined with GH administration or GH administration alone.
Summary · context
Real-time quantitative RT-PCR was used to determine mRNA levels in biopsies from the vastus lateralis muscle at baseline, after 5 and 12 weeks in the three groups.
Report a problemFND-1456599405
02HumanNon-randomized trialMechanism
In healthy elderly men, GH alone significantly increased muscle IGF-IEa mRNA by 237% at 5 weeks versus baseline.
In plain wordsIn elderly men, GH alone increased muscle IGF-IEa mRNA by 237% at 5 weeks versus baseline.
Peptide
HGH (somatotropin)
Outcome
IncreaseIGF-IEa mRNA at 5 weeks
Study
n: not reported in source
Comparator
Baseline
Outcome group
Growth hormone and IGF-1 · Musculoskeletal
Studied dose
Dose not stated
Measurements
IGF-IEa mRNA increase
237%
GH alone at 5 weeks
Source sentences
Summary
GH administration did not change MGF mRNA at 5 weeks, but significantly increased IGF-IEa mRNA (237%).
3 context sentences(design, population, supporting numbers)
Summary · context
The expression of two isoforms of insulin-like growth factor-I (IGF-I): mechano growth factor (MGF) and IGF-IEa were studied in muscle in response to growth hormone (GH) administration with and without resistance training in healthy elderly men.
Summary · context
The subjects (age 74 +/- 1 years, mean +/- S.E.M) were assigned to either resistance training with placebo, resistance training combined with GH administration or GH administration alone.
Summary · context
Real-time quantitative RT-PCR was used to determine mRNA levels in biopsies from the vastus lateralis muscle at baseline, after 5 and 12 weeks in the three groups.
Report a problemFND-1456599406
03HumanNon-randomized trialMechanism
In healthy elderly men, GH alone significantly increased muscle MGF mRNA by 80% at 12 weeks versus baseline.
In plain wordsIn elderly men, GH alone increased muscle MGF mRNA by 80% at 12 weeks versus baseline.
Peptide
HGH (somatotropin)
Outcome
IncreaseMGF mRNA at 12 weeks
Study
n: not reported in source
Comparator
Baseline
Outcome group
Growth hormone and IGF-1 · Musculoskeletal
Studied dose
Dose not stated
Measurements
MGF mRNA increase
80%
GH alone at 12 weeks
Source sentences
Summary
After 12 weeks, MGF mRNA was significantly increased (80%) compared to baseline.
3 context sentences(design, population, supporting numbers)
Summary · context
The expression of two isoforms of insulin-like growth factor-I (IGF-I): mechano growth factor (MGF) and IGF-IEa were studied in muscle in response to growth hormone (GH) administration with and without resistance training in healthy elderly men.
Summary · context
The subjects (age 74 +/- 1 years, mean +/- S.E.M) were assigned to either resistance training with placebo, resistance training combined with GH administration or GH administration alone.
Summary · context
Real-time quantitative RT-PCR was used to determine mRNA levels in biopsies from the vastus lateralis muscle at baseline, after 5 and 12 weeks in the three groups.
Report a problemFND-1456599407

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

04HumanEndogenous levelRandomized controlled trialMechanism
In healthy elderly men, 5 weeks of growth hormone administration alone did not change MGF mRNA levels in vastus lateralis muscle.
In plain wordsIn elderly men, growth hormone alone did not change the body's own MGF activity in muscle after 5 weeks.
Peptide
MGF / PEG-MGF
Outcome
No significant changeMuscle MGF mRNA after GH alone, week 5
Study
n: not reported in source
Comparator
Baseline
Outcome group
Growth hormone and IGF-1 · Musculoskeletal
Source sentences
Summary
GH administration did not change MGF mRNA at 5 weeks
2 context sentences(design, population, supporting numbers)
Summary · context
The expression of two isoforms of insulin-like growth factor-I (IGF-I): mechano growth factor (MGF) and IGF-IEa were studied in muscle in response to growth hormone (GH) administration with and without resistance training in healthy elderly men.
Summary · context
The subjects (age 74 +/- 1 years, mean +/- S.E.M) were assigned to either resistance training with placebo, resistance training combined with GH administration or GH administration alone.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1456599401
05HumanEndogenous levelRandomized controlled trialMechanism
In healthy elderly men, MGF mRNA in muscle was 80% higher than baseline after 12 weeks, in the growth hormone group.
In plain wordsIn elderly men, the body's own MGF activity in muscle rose after 12 weeks of growth hormone compared with baseline.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMuscle MGF mRNA after GH alone, week 12
Study
n: not reported in source
Comparator
Baseline
Outcome group
Growth hormone and IGF-1 · Musculoskeletal
Measurements
MGF mRNA change
80%
12 weeks
Source sentences
Summary
After 12 weeks, MGF mRNA was significantly increased (80%) compared to baseline.
2 context sentences(design, population, supporting numbers)
Summary · context
The expression of two isoforms of insulin-like growth factor-I (IGF-I): mechano growth factor (MGF) and IGF-IEa were studied in muscle in response to growth hormone (GH) administration with and without resistance training in healthy elderly men.
Summary · context
The subjects (age 74 +/- 1 years, mean +/- S.E.M) were assigned to either resistance training with placebo, resistance training combined with GH administration or GH administration alone.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1456599402
06HumanEndogenous levelRandomized controlled trialMechanism
In healthy elderly men, 5 weeks of resistance training increased MGF mRNA in muscle by 163%.
In plain wordsIn elderly men, 5 weeks of resistance training raised the body's own MGF activity in muscle.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMuscle MGF mRNA after resistance training, week 5
Study
n: not reported in source
Comparator
Baseline
Outcome group
Growth hormone and IGF-1 · Musculoskeletal
Measurements
MGF mRNA change
163%
resistance training, 5 weeks
Source sentences
Summary
Five weeks of resistance training significantly increased the mRNA expression of MGF (163%)
2 context sentences(design, population, supporting numbers)
Summary · context
The expression of two isoforms of insulin-like growth factor-I (IGF-I): mechano growth factor (MGF) and IGF-IEa were studied in muscle in response to growth hormone (GH) administration with and without resistance training in healthy elderly men.
Summary · context
The subjects (age 74 +/- 1 years, mean +/- S.E.M) were assigned to either resistance training with placebo, resistance training combined with GH administration or GH administration alone.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1456599403
07HumanEndogenous levelRandomized controlled trialMechanism
In healthy elderly men, 5 weeks of resistance training combined with growth hormone increased MGF mRNA in muscle by 456%.
In plain wordsIn elderly men, training combined with growth hormone raised the body's own MGF activity in muscle after 5 weeks, compared with baseline.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMuscle MGF mRNA after training plus GH, week 5
Study
n: not reported in source
Comparator
Baseline
Outcome group
Growth hormone and IGF-1 · Musculoskeletal
Measurements
MGF mRNA change
456%
training plus GH, 5 weeks
Source sentences
Summary
after 5 weeks of training combined with GH treatment, MGF mRNA increased significantly (456%)
2 context sentences(design, population, supporting numbers)
Summary · context
The expression of two isoforms of insulin-like growth factor-I (IGF-I): mechano growth factor (MGF) and IGF-IEa were studied in muscle in response to growth hormone (GH) administration with and without resistance training in healthy elderly men.
Summary · context
The subjects (age 74 +/- 1 years, mean +/- S.E.M) were assigned to either resistance training with placebo, resistance training combined with GH administration or GH administration alone.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1456599404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:36 UTC
Study data updated · source update from Europe PMC
Version 2
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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