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Study · Measured the body's own peptide · 2003

3 results

The effects of serotonin on the differentiation of neurons producing vasoactive intestinal polypeptide in the suprachiasmatic nucleus of the rat.

Mirochnik VV, Ugryumov MV, Bosler O, Calas A

Neuroscience and behavioral physiology1 Sept 2003Cited by 3 (Europe PMC)

PMID14552543 (opens in a new tab)DOI10.1023/a:1024477227552 (opens in a new tab)PepBankPUB-14552543
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In adult rats whose mothers had PCPA-induced serotonin deficiency, VIP mRNA concentrations in suprachiasmatic nucleus neurons did not differ from controls.

    In plain wordsIn rats with serotonin deficiency before birth, the body's own VIP gene activity in these brain cells did not differ from controls.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeVIP mRNA concentration in suprachiasmatic neurons
    Study

    ratn: not reported in source

    Suprachiasmatic nucleus of adult rats after prenatal serotonin deficiency
    Comparator
    Control rats (mothers treated with 0.9% NaCl)
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    VIP neurons in experimental and control animals were found to show no differences in VIP mRNA concentrations and, probably, in the level of VIP synthesis.
    2 context sentences
    Summary · context
    This was addressed by comparative morphofunctional analysis of VIP neurons in adult rats whose brains developed prenatally in conditions of normal and deficient serotonin metabolism.
    Summary · context
    Serotonin deficiency was created in fetuses by treatment of their mothers with p-chlorophenylalanine (PCPA).

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In adult rats whose mothers had PCPA-induced serotonin deficiency, the number of VIP-immunoreactive neurons in the suprachiasmatic nucleus was higher than in controls.

    In plain wordsIn rats with serotonin deficiency before birth, the body's own VIP-producing brain cells were more numerous than in controls.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseNumber of VIP-immunoreactive neurons
    Study

    ratn: not reported in source

    Suprachiasmatic nucleus of adult rats after prenatal serotonin deficiency
    Comparator
    Control rats (mothers treated with 0.9% NaCl)
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    However, inhibition of serotonin synthesis led to an increase in the number of VIP-immunoreactive neurons and an increase in the VIP concentration within these cells.
    2 context sentences
    Summary · context
    This was addressed by comparative morphofunctional analysis of VIP neurons in adult rats whose brains developed prenatally in conditions of normal and deficient serotonin metabolism.
    Summary · context
    Serotonin deficiency was created in fetuses by treatment of their mothers with p-chlorophenylalanine (PCPA).

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In adult rats whose mothers had PCPA-induced serotonin deficiency, the VIP concentration within suprachiasmatic neurons was higher than in controls.

    In plain wordsIn rats with serotonin deficiency before birth, the body's own VIP inside these brain cells was higher than in controls.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP concentration within suprachiasmatic neurons
    Study

    ratn: not reported in source

    Suprachiasmatic nucleus of adult rats after prenatal serotonin deficiency
    Comparator
    Control rats (mothers treated with 0.9% NaCl)
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    However, inhibition of serotonin synthesis led to an increase in the number of VIP-immunoreactive neurons and an increase in the VIP concentration within these cells.
    2 context sentences
    Summary · context
    This was addressed by comparative morphofunctional analysis of VIP neurons in adult rats whose brains developed prenatally in conditions of normal and deficient serotonin metabolism.
    Summary · context
    Serotonin deficiency was created in fetuses by treatment of their mothers with p-chlorophenylalanine (PCPA).

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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