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Study · Animal study (in vivo) · rat · 2003

4 results

The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats.

Kozlovskii II, Danchev ND

Neuroscience and behavioral physiology1 Sept 2003Cited by 6 (Europe PMC)

PMID14552529 (opens in a new tab)DOI10.1023/a:1024444321191 (opens in a new tab)PepBankPUB-14552529
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with initially poor learning ability, repeated Selank significantly activated the learning process, with effects apparent after the first dose on training day 1.

    In plain wordsIn rats with poor learning ability, Selank improved learning from the first day of training.

    Peptide
    Selank
    Outcome
    IncreaseLearning in rats with initially poor learning ability
    Study

    ratn: not reported in source

    conditioned active avoidance reflex
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 microg/kg · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    These experiments showed that Selank significantly activated the learning process in rats with initially poor learning ability, with effects apparent after first dose on training day 1.
    1 context sentence
    Summary · context
    The actions of the synthetic heptapeptide preparation Selank on learning and memory processes in rats with initially low levels of learning ability were compared with those in normal rats, using a method based on acquisition of a conditioned active avoidance reflex, with repeated administration of p…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, repeated Selank administration progressively increased the total number of correct solutions (p < 0.05).

    In plain wordsIn rats given Selank repeatedly, correct answers in learning tests increased over the days.

    Peptide
    Selank
    Outcome
    IncreaseNumber of correct solutions
    Study

    ratn: not reported in source

    conditioned active avoidance reflex
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 microg/kg · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    The effect progressively increased on repeated administration of Selank: the total number of correct solutions increased and the number of errors decreased (p < 0.05).
    1 context sentence
    Summary · context
    The actions of the synthetic heptapeptide preparation Selank on learning and memory processes in rats with initially low levels of learning ability were compared with those in normal rats, using a method based on acquisition of a conditioned active avoidance reflex, with repeated administration of p…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, repeated Selank administration progressively decreased the number of errors (p < 0.05).

    In plain wordsIn rats given Selank repeatedly, errors in learning tests decreased over the days.

    Peptide
    Selank
    Outcome
    DecreaseNumber of errors
    Study

    ratn: not reported in source

    conditioned active avoidance reflex
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 microg/kg · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    The effect progressively increased on repeated administration of Selank: the total number of correct solutions increased and the number of errors decreased (p < 0.05).
    1 context sentence
    Summary · context
    The actions of the synthetic heptapeptide preparation Selank on learning and memory processes in rats with initially low levels of learning ability were compared with those in normal rats, using a method based on acquisition of a conditioned active avoidance reflex, with repeated administration of p…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In normal rats, the maximum optimizing activity of Selank on learning was seen on day 3 of repeated administration and training.

    In plain wordsIn normal rats, Selank improved learning most on day 3 of repeated dosing and training.

    Peptide
    Selank
    Outcome
    IncreaseLearning in normal rats
    Study

    ratn: not reported in source

    conditioned active avoidance reflex
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 microg/kg · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    The maximum optimizing activity of Selank on learning in normal rats was seen on day 3 of repeated administration and training, i.e., after formation of the initial consolidation phase.
    1 context sentence
    Summary · context
    The actions of the synthetic heptapeptide preparation Selank on learning and memory processes in rats with initially low levels of learning ability were compared with those in normal rats, using a method based on acquisition of a conditioned active avoidance reflex, with repeated administration of p…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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