Endocrine and metabolic effects of growth hormone (GH) compared with GH-releasing peptide, thyrotropin-releasing hormone, and insulin infusion in a rabbit model of prolonged critical illness.

Weekers F, Michalaki M, Coopmans W, Van Herck E, Veldhuis JD, Darras VM, Van den Berghe G

Endocrinology9 Oct 2003Cited by 32 (Europe PMC)

PMID14551231DOI10.1210/en.2003-1005PepBankPUB-14551231

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone12

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

01AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, mortality was equal in the saline, GHRP‑2 plus TRH plus insulin, and rhGH groups.
In plain wordsIn ill rabbits, death rates were the same with saline, GHRP‑2 plus TRH plus insulin, and growth hormone.
Peptide
GHRP-2
Outcome
No significant changeMortality in three groups
Study
rabbitn = 24
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Outcome group
Mortality · Whole body
Source sentences
Summary
Mortality, organ system function, hyperglycemia, and insulin requirement were equal in the three groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123101
02AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, organ system function was equal in the three treatment groups.
In plain wordsIn ill rabbits, organ function was the same in all three treatment groups.
Peptide
GHRP-2
Outcome
No significant changeOrgan system function in three groups
Study
rabbitn = 24
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Outcome group
Adverse events · Whole body
Source sentences
Summary
Mortality, organ system function, hyperglycemia, and insulin requirement were equal in the three groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123102
03AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, hyperglycemia was equal in the three treatment groups.
In plain wordsIn ill rabbits, high blood sugar was the same in all three treatment groups.
Peptide
GHRP-2
Outcome
No significant changeHyperglycemia in three groups
Study
rabbitn = 24
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Mortality, organ system function, hyperglycemia, and insulin requirement were equal in the three groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123103
04AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, insulin requirement was equal in the three treatment groups.
In plain wordsIn ill rabbits, the insulin needed was the same in all three treatment groups.
Peptide
GHRP-2
Outcome
No significant changeInsulin requirement in three groups
Study
rabbitn = 24
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Mortality, organ system function, hyperglycemia, and insulin requirement were equal in the three groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123104
05AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, IGF-I rose less with GHRP‑2 plus TRH than with rhGH.
In plain wordsIn ill rabbits, IGF-I rose less with GHRP‑2 plus TRH than with growth hormone.
Peptide
GHRP-2
Outcome
DecreaseIGF-I, GHRP-2 plus TRH versus rhGH
Study
rabbitn = 16
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Comparator
rhGH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
increased IGF-I more than GHRP-2+TRH without altering thyroid hormone levels.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123112
06AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, GHRP‑2 plus TRH increased pulsatile rabbit GH release on day 1.
In plain wordsIn ill rabbits, GHRP‑2 plus TRH raised pulses of growth hormone release on day 1.
Peptide
GHRP-2
Outcome
IncreasePulsatile rabbit GH release on day 1
Study
rabbitn = 9
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
GHRP-2+TRH increased pulsatile rabbit GH (rGH) and TSH release on d 1.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123105
07AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, GHRP‑2 plus TRH increased pulsatile TSH release on day 1.
In plain wordsIn ill rabbits, GHRP‑2 plus TRH raised pulses of TSH release on day 1.
Peptide
GHRP-2
Outcome
IncreasePulsatile TSH release on day 1
Study
rabbitn = 9
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Outcome group
Thyroid function · Endocrine and hormones
Source sentences
Summary
GHRP-2+TRH increased pulsatile rabbit GH (rGH) and TSH release on d 1.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123106
08AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, rabbit GH secretion was elevated after 4 days of GHRP‑2 plus TRH.
In plain wordsIn ill rabbits, growth hormone release was higher after 4 days of GHRP‑2 plus TRH.
Peptide
GHRP-2
Outcome
IncreaseRabbit GH secretion after 4 days
Study
rabbitn = 9
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
After 4 d, rGH secretion and T4 and T3 concentrations were elevated, with a significant increase in hepatic activity of type 1 deiodinase and a decrease in type 3 deiodinase.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123107
09AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, T4 concentrations were elevated after 4 days of GHRP‑2 plus TRH.
In plain wordsIn ill rabbits, T4 thyroid hormone was higher after 4 days of GHRP‑2 plus TRH.
Peptide
GHRP-2
Outcome
IncreaseT4 concentration after 4 days
Study
rabbitn = 9
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Outcome group
Thyroid function · Endocrine and hormones
Source sentences
Summary
After 4 d, rGH secretion and T4 and T3 concentrations were elevated, with a significant increase in hepatic activity of type 1 deiodinase and a decrease in type 3 deiodinase.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123108
10AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, T3 concentrations were elevated after 4 days of GHRP‑2 plus TRH.
In plain wordsIn ill rabbits, T3 thyroid hormone was higher after 4 days of GHRP‑2 plus TRH.
Peptide
GHRP-2
Outcome
IncreaseT3 concentration after 4 days
Study
rabbitn = 9
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Outcome group
Thyroid function · Endocrine and hormones
Source sentences
Summary
After 4 d, rGH secretion and T4 and T3 concentrations were elevated, with a significant increase in hepatic activity of type 1 deiodinase and a decrease in type 3 deiodinase.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123109
11AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, GHRP‑2 plus TRH significantly increased hepatic type 1 deiodinase activity.
In plain wordsIn ill rabbits, GHRP‑2 plus TRH raised the activity of a liver enzyme that makes active thyroid hormone.
Peptide
GHRP-2
Outcome
IncreaseHepatic type 1 deiodinase activity
Study
rabbitn = 9
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Outcome group
Thyroid function · Endocrine and hormones
Source sentences
Summary
After 4 d, rGH secretion and T4 and T3 concentrations were elevated, with a significant increase in hepatic activity of type 1 deiodinase and a decrease in type 3 deiodinase.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123110
12AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In burn-injured rabbits, GHRP‑2 plus TRH decreased hepatic type 3 deiodinase activity.
In plain wordsIn ill rabbits, GHRP‑2 plus TRH lowered the activity of a liver enzyme that inactivates thyroid hormone.
Peptide
GHRP-2
Outcome
DecreaseHepatic type 3 deiodinase activity
Study
rabbitn = 9
Burn-injured, parenterally fed New Zealand White rabbits (prolonged critical illness)
Outcome group
Thyroid function · Endocrine and hormones
Source sentences
Summary
After 4 d, rGH secretion and T4 and T3 concentrations were elevated, with a significant increase in hepatic activity of type 1 deiodinase and a decrease in type 3 deiodinase.
2 context sentences(design, population, supporting numbers)
Summary · context
Burn-injured, parenterally fed, New Zealand White rabbits were randomized to receive 4-d treatment with saline (n=8); 60 microg/kg.h GHRP-2 and 60 microg/kg.h TRH, i.v. (n=9); or 3.5 mg/kg rhGH, s.c. (n=7).
Summary · context
In the GHRP-2+TRH group, insulin was adjusted to maintain blood glucose below 180 mg/dl.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1455123111

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.