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Study · Not a test of the peptide alone · 2003

1 result

Agonist-dependent internalization of the human melanocortin-4 receptors in human embryonic kidney 293 cells.

Gao Z, Lei D, Welch J, Le K, Lin J, Leng S, Duhl D

The Journal of pharmacology and experimental therapeutics8 Oct 2003Cited by 29 (Europe PMC)

PMID14534363 (opens in a new tab)DOI10.1124/jpet.103.055525 (opens in a new tab)PepBankPUB-14534363
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 01LabNot a test of Melanotan II aloneIn vitro (cells)Mechanism

    In HEK-293 cells, a fluorescent rhodamine derivative of MTII co-internalized with MC4R-GFP into intracellular vesicles.

    In plain wordsIn cells, a glowing version of MTII entered the cell together with its receptor.

    Peptide
    Melanotan II
    Outcome
    Not applicableCo-internalization of rhodamine-MTII with MC4R-GFP
    Study

    humann: not reported in source

    HEK-293 cells expressing MC4R-GFP
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Rhodamine-[AcNle-c[Asp-His-d-Phe-Arg-Trp-Lys]-NH2] (MTII), a fluorescent derivative of an MC4R agonist, was found to cointernalize with MC4R-GFP into intracellular vesicles.
    1 context sentence
    Summary · context
    As observed with a confocal microscope, in human embryonic kidney (HEK)-293 cells MC4R/GFP was distributed evenly along the cell membrane.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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