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Study · Not a test of the peptide alone · 2003

3 results

Interaction of bovine granulosa and theca cells in a novel serum-free co-culture system.

Allegrucci C, Hunter MG, Webb R, Luck MR

Reproduction (Cambridge, England)1 Oct 2003Cited by 21 (Europe PMC)

PMID14525535 (opens in a new tab)DOI10.1530/rep.0.1260527 (opens in a new tab)PepBankPUB-14525535
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

  1. 01LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Activity measurement

    In a bovine granulosa and theca cell co-culture, treatment A (FSH, LH and LR3 IGF-I) increased androstenedione secretion versus controls.

    In plain wordsIn cow ovary cells in the lab, a mix of FSH, LH and LR3 IGF-I raised androstenedione compared with controls.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseAndrostenedione secretion with treatment A
    Study

    bovinen: not reported in source

    Bovine granulosa and theca cell co-culture, serum-free
    Comparator
    Controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Significantly more androstenedione was secreted in the presence of treatment A compared with controls.
    2 context sentences
    Summary · context
    Granulosa and theca cells from follicles 4-6 mm in diameter were cultured on either side of laminin-coated BioCoat cell culture inserts in a serum-free medium containing 10 ng insulin ml(-1) at plating densities of 10(5) and 3 x 10(5) cells per membrane side.
    Summary · context
    Co-cultures at both cell plating densities were responsive to treatment with physiological combinations of either FSH, LH and LR3 insulin-like growth factor I (IGF-I) (treatment A) or FSH, LR3 IGF-I and androstenedione (treatment B).

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  2. 02LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Activity measurement

    In a bovine granulosa and theca cell co-culture, estradiol secretion increased only with treatment B (FSH, LR3 IGF-I and androstenedione).

    In plain wordsIn cow ovary cells in the lab, estradiol rose only with the mix of FSH, LR3 IGF-I and androstenedione.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseEstradiol secretion with treatment B
    Study

    bovinen: not reported in source

    Bovine granulosa and theca cell co-culture, serum-free
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In contrast, oestradiol secretion was increased only by treatment B.
    2 context sentences
    Summary · context
    Granulosa and theca cells from follicles 4-6 mm in diameter were cultured on either side of laminin-coated BioCoat cell culture inserts in a serum-free medium containing 10 ng insulin ml(-1) at plating densities of 10(5) and 3 x 10(5) cells per membrane side.
    Summary · context
    Co-cultures at both cell plating densities were responsive to treatment with physiological combinations of either FSH, LH and LR3 insulin-like growth factor I (IGF-I) (treatment A) or FSH, LR3 IGF-I and androstenedione (treatment B).

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  3. 03LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Activity measurement

    In a bovine granulosa and theca cell co-culture, progesterone secretion was unaffected by treatments A and B.

    In plain wordsIn cow ovary cells in the lab, the hormone mixes did not change progesterone secretion.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeProgesterone secretion
    Study

    bovinen: not reported in source

    Bovine granulosa and theca cell co-culture, serum-free
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Progesterone secretion was unaffected by treatment and did not increase during culture.
    2 context sentences
    Summary · context
    Granulosa and theca cells from follicles 4-6 mm in diameter were cultured on either side of laminin-coated BioCoat cell culture inserts in a serum-free medium containing 10 ng insulin ml(-1) at plating densities of 10(5) and 3 x 10(5) cells per membrane side.
    Summary · context
    Co-cultures at both cell plating densities were responsive to treatment with physiological combinations of either FSH, LH and LR3 insulin-like growth factor I (IGF-I) (treatment A) or FSH, LR3 IGF-I and androstenedione (treatment B).

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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