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Study · Randomized controlled trial · n = 49 · 2003

6 results

Lack of effect of a single i.v. dose of oxytocin on sperm output in severely oligozoospermic men.

Byrne MM, Rolf C, Depenbusch M, Cooper TG, Nieschlag E

Human reproduction (Oxford, England)1 Oct 2003Cited by 12 (Europe PMC)

PMID14507828 (opens in a new tab)DOI10.1093/humrep/deg416 (opens in a new tab)PepBankPUB-14507828
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In men with severe oligozoospermia, a single intravenous dose of oxytocin did not change ejaculate volume compared with saline.

    In plain wordsIn men with very low sperm counts, one oxytocin injection did not change semen volume compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeEjaculate volume
    Study

    n = 49

    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.75 IU · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    A single i.v. dose of oxytocin resulted in no change in ejaculate volume (P = 0.4)
    2 context sentences
    Summary · context
    Forty-nine infertile men with sperm concentrations <0.2 x 10(6)/ml were studied on two occasions after 3-4 days of sexual abstinence.
    Summary · context
    They received an i.v. injection of saline or oxytocin 0.75 IU in random order, and commenced masturbation within 5 min.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In men with severe oligozoospermia, a single intravenous dose of oxytocin did not change total sperm count compared with saline.

    In plain wordsIn men with very low sperm counts, one oxytocin injection did not change total sperm count compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeTotal sperm count
    Study

    n = 49

    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.75 IU · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    total sperm count (P = 0.14) or sperm motility (P = 0.9).
    2 context sentences
    Summary · context
    Forty-nine infertile men with sperm concentrations <0.2 x 10(6)/ml were studied on two occasions after 3-4 days of sexual abstinence.
    Summary · context
    They received an i.v. injection of saline or oxytocin 0.75 IU in random order, and commenced masturbation within 5 min.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In men with severe oligozoospermia, a single intravenous dose of oxytocin did not change sperm motility compared with saline.

    In plain wordsIn men with very low sperm counts, one oxytocin injection did not change sperm motility compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeSperm motility
    Study

    n = 49

    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.75 IU · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    sperm motility (P = 0.9).
    2 context sentences
    Summary · context
    Forty-nine infertile men with sperm concentrations <0.2 x 10(6)/ml were studied on two occasions after 3-4 days of sexual abstinence.
    Summary · context
    They received an i.v. injection of saline or oxytocin 0.75 IU in random order, and commenced masturbation within 5 min.
  4. 04HumanRandomized controlled trialOther

    In men with severe oligozoospermia given oxytocin, the change in total sperm count was not significantly correlated with FSH levels.

    In plain wordsIn men with very low sperm counts, the change in sperm count after oxytocin was not linked to FSH levels.

    Peptide
    Oxytocin
    Outcome
    No significant changeCorrelation of change in total sperm count with FSH
    Study

    n = 49

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.75 IU · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    There was no significant correlation between the change in total sperm count and FSH levels (r = -0.32, P = 0.2)
    2 context sentences
    Summary · context
    Forty-nine infertile men with sperm concentrations <0.2 x 10(6)/ml were studied on two occasions after 3-4 days of sexual abstinence.
    Summary · context
    They received an i.v. injection of saline or oxytocin 0.75 IU in random order, and commenced masturbation within 5 min.
  5. 05HumanRandomized controlled trialOther

    In men with severe oligozoospermia given oxytocin, the change in total sperm count was not significantly correlated with estradiol levels.

    In plain wordsIn men with very low sperm counts, the change in sperm count after oxytocin was not linked to estradiol levels.

    Peptide
    Oxytocin
    Outcome
    No significant changeCorrelation of change in total sperm count with estradiol
    Study

    n = 49

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.75 IU · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    or the change in total sperm count and estradiol levels (r = -0.02, P = 0.9).
    2 context sentences
    Summary · context
    Forty-nine infertile men with sperm concentrations <0.2 x 10(6)/ml were studied on two occasions after 3-4 days of sexual abstinence.
    Summary · context
    They received an i.v. injection of saline or oxytocin 0.75 IU in random order, and commenced masturbation within 5 min.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In a subgroup of men with total sperm counts below 100, oxytocin gave similar results, with no change in seminal parameters.

    In plain wordsIn the subgroup of men with the lowest sperm counts, one oxytocin injection gave similar results with no change.

    Peptide
    Oxytocin
    Outcome
    No significant changeSeminal parameters in men with total sperm counts below 100
    Study

    n: not reported in source

    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.75 IU · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    Similar results were found in a subgroup of men with total sperm counts of <100.
    2 context sentences
    Summary · context
    Forty-nine infertile men with sperm concentrations <0.2 x 10(6)/ml were studied on two occasions after 3-4 days of sexual abstinence.
    Summary · context
    They received an i.v. injection of saline or oxytocin 0.75 IU in random order, and commenced masturbation within 5 min.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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