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Study · Animal study (in vivo) · rat · 2003

4 results

Growth hormone-releasing peptide-6 inhibits cerebellar cell death in aged rats.

Pañeda C, Arroba AI, Frago LM, Holm AM, Rømer J, Argente J, Chowen JA

Neuroreport1 Aug 2003Cited by 18 (Europe PMC)

PMID14502090 (opens in a new tab)DOI10.1097/00001756-200308260-00018 (opens in a new tab)PepBankPUB-14502090
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats, GHRP‑6 increased IGF-I mRNA levels in the cerebellum.

    In plain wordsIn aged rats, GHRP‑6 raised the level of IGF-I messenger RNA in the cerebellum.

    Peptide
    GHRP-6
    Outcome
    IncreaseCerebellar IGF-I mRNA level
    Study

    ratn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Growth hormone-releasing peptide (GHRP)-6, a synthetic ligand for the ghrelin receptor, increased IGF-I mRNA levels, decreased cell death and inhibited caspase 3 and 9 activation in the cerebellum of aged rats.
    1 context sentence
    Summary · context
    Here we show that IGF-I mRNA levels are decreased in the cerebellum of old rats compared with young rats and this was associated with increased cell death and activation of caspases 3 and 9.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats, GHRP‑6 decreased cell death in the cerebellum.

    In plain wordsIn aged rats, GHRP‑6 reduced cell death in the cerebellum.

    Peptide
    GHRP-6
    Outcome
    DecreaseCerebellar cell death
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Growth hormone-releasing peptide (GHRP)-6, a synthetic ligand for the ghrelin receptor, increased IGF-I mRNA levels, decreased cell death and inhibited caspase 3 and 9 activation in the cerebellum of aged rats.
    1 context sentence
    Summary · context
    Here we show that IGF-I mRNA levels are decreased in the cerebellum of old rats compared with young rats and this was associated with increased cell death and activation of caspases 3 and 9.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In aged rats, GHRP‑6 inhibited caspase 3 activation in the cerebellum.

    In plain wordsIn aged rats, GHRP‑6 blocked activation of the cell-death enzyme caspase 3 in the cerebellum.

    Peptide
    GHRP-6
    Outcome
    DecreaseCerebellar caspase 3 activation
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Growth hormone-releasing peptide (GHRP)-6, a synthetic ligand for the ghrelin receptor, increased IGF-I mRNA levels, decreased cell death and inhibited caspase 3 and 9 activation in the cerebellum of aged rats.
    1 context sentence
    Summary · context
    Here we show that IGF-I mRNA levels are decreased in the cerebellum of old rats compared with young rats and this was associated with increased cell death and activation of caspases 3 and 9.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In aged rats, GHRP‑6 inhibited caspase 9 activation in the cerebellum.

    In plain wordsIn aged rats, GHRP‑6 blocked activation of the cell-death enzyme caspase 9 in the cerebellum.

    Peptide
    GHRP-6
    Outcome
    DecreaseCerebellar caspase 9 activation
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Growth hormone-releasing peptide (GHRP)-6, a synthetic ligand for the ghrelin receptor, increased IGF-I mRNA levels, decreased cell death and inhibited caspase 3 and 9 activation in the cerebellum of aged rats.
    1 context sentence
    Summary · context
    Here we show that IGF-I mRNA levels are decreased in the cerebellum of old rats compared with young rats and this was associated with increased cell death and activation of caspases 3 and 9.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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