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Study · Animal study (in vivo) · mouse (female swiss-derived shr) · 2003

9 results

Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.

Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NY, Semenchenko AV, Yashin AI

Biogerontology1 Jan 2003Cited by 10 (Europe PMC)

PMID14501183 (opens in a new tab)DOI10.1023/a:1025114230714 (opens in a new tab)PepBankPUB-14501183
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In female SHR mice, long-term Epitalon treatment did not influence food consumption.

    In plain wordsIn mice, long-term Epitalon did not change food intake compared with saline.

    Peptide
    Epitalon
    Outcome
    No significant changeFood consumption
    Study

    Mouse (female Swiss-derived SHR)n = 54

    Comparator
    Saline control
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1.0 µg/mouse · subcutaneous · From 3 months of age until natural death, 5 consecutive days every monthAs given in this study (Mouse (female Swiss-derived SHR)).

    Source sentences

    Summary
    The results of this study show that treatment with Epitalon did not influence food consumption, body weight or mean life span of mice.
    1 context sentence
    Summary · context
    From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In female SHR mice, long-term Epitalon treatment did not influence body weight.

    In plain wordsIn mice, long-term Epitalon did not change body weight compared with saline.

    Peptide
    Epitalon
    Outcome
    No significant changeBody weight
    Study

    Mouse (female Swiss-derived SHR)n = 54

    Comparator
    Saline control
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1.0 µg/mouse · subcutaneous · From 3 months of age until natural death, 5 consecutive days every monthAs given in this study (Mouse (female Swiss-derived SHR)).

    Source sentences

    Summary
    The results of this study show that treatment with Epitalon did not influence food consumption, body weight or mean life span of mice.
    1 context sentence
    Summary · context
    From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female SHR mice, Epitalon treatment did not influence mean life span.

    In plain wordsIn mice, Epitalon did not change average life span compared with saline.

    Peptide
    Epitalon
    Outcome
    No significant changeMean life span
    Study

    Mouse (female Swiss-derived SHR)n = 54

    Comparator
    Saline control
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    1.0 µg/mouse · subcutaneous · From 3 months of age until natural death, 5 consecutive days every monthAs given in this study (Mouse (female Swiss-derived SHR)).

    Source sentences

    Summary
    The results of this study show that treatment with Epitalon did not influence food consumption, body weight or mean life span of mice.
    1 context sentence
    Summary · context
    From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female SHR mice, Epitalon slowed down the age-related switching-off of estrous function.

    In plain wordsIn female mice, Epitalon slowed the age-related loss of estrous cycles compared with saline.

    Peptide
    Epitalon
    Outcome
    DecreaseAge-related switching-off of estrous function
    Study

    Mouse (female Swiss-derived SHR)n = 54

    Comparator
    Saline control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1.0 µg/mouse · subcutaneous · From 3 months of age until natural death, 5 consecutive days every monthAs given in this study (Mouse (female Swiss-derived SHR)).

    Source sentences

    Summary
    However, it slowed down the age-related switching-off of estrous function
    1 context sentence
    Summary · context
    From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In female SHR mice, Epitalon increased by 13.3% the life span of the last 10% of survivors (P<0.01).

    In plain wordsIn mice, Epitalon extended the life span of the longest-lived 10% compared with saline.

    Peptide
    Epitalon
    Outcome
    IncreaseLife span of the last 10% of survivors
    Study

    Mouse (female Swiss-derived SHR)n = 54

    Comparator
    Saline control
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    1.0 µg/mouse · subcutaneous · From 3 months of age until natural death, 5 consecutive days every monthAs given in this study (Mouse (female Swiss-derived SHR)).

    Measurements

    Increase in life span of last 10% of survivors
    13.3%
    Epitalon vs control

    Source sentences

    Summary
    It also increased by 13.3% the life span of the last 10% of the survivors (P<0.01)
    1 context sentence
    Summary · context
    From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In female SHR mice, Epitalon increased the maximum life span by 12.3% compared with the control group.

    In plain wordsIn mice, Epitalon increased the maximum life span compared with saline.

    Peptide
    Epitalon
    Outcome
    IncreaseMaximum life span
    Study

    Mouse (female Swiss-derived SHR)n = 54

    Comparator
    Saline control
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    1.0 µg/mouse · subcutaneous · From 3 months of age until natural death, 5 consecutive days every monthAs given in this study (Mouse (female Swiss-derived SHR)).

    Measurements

    Increase in maximum life span
    12.3%
    Epitalon vs control

    Source sentences

    Summary
    and by 12.3% the maximum life span in comparison with the control group.
    1 context sentence
    Summary · context
    From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline.
  7. 07AnimalAnimal study (in vivo)Safety outcome

    In female SHR mice, Epitalon treatment did not influence total spontaneous tumor incidence.

    In plain wordsIn mice, Epitalon did not change the overall rate of spontaneous tumors compared with saline.

    Peptide
    Epitalon
    Outcome
    No significant changeTotal spontaneous tumor incidence
    Study

    Mouse (female Swiss-derived SHR)n = 54

    Comparator
    Saline control
    Outcome group
    Tumor growth · Cancer
    Studied dose
    1.0 µg/mouse · subcutaneous · From 3 months of age until natural death, 5 consecutive days every monthAs given in this study (Mouse (female Swiss-derived SHR)).

    Source sentences

    Summary
    We also found that treatment with Epitalon did not influence total spontaneous tumor incidence
    1 context sentence
    Summary · context
    From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In female SHR mice, Epitalon inhibited the development of leukemia (6.0-fold) compared with the control group.

    In plain wordsIn mice, Epitalon reduced the development of leukemia compared with saline.

    Peptide
    Epitalon
    Outcome
    DecreaseDevelopment of leukemia
    Study

    Mouse (female Swiss-derived SHR)n = 54

    Comparator
    Saline control
    Outcome group
    Tumor growth · Cancer
    Studied dose
    1.0 µg/mouse · subcutaneous · From 3 months of age until natural death, 5 consecutive days every monthAs given in this study (Mouse (female Swiss-derived SHR)).

    Measurements

    Reduction in leukemia development
    6 fold
    Epitalon vs control

    Source sentences

    Summary
    but inhibited the development of leukemia (6.0-fold), as compared with the control group.
    1 context sentence
    Summary · context
    From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In female SHR mice, Epitalon decreased the frequency of chromosome aberrations in bone marrow cells by 17.1% (P<0.05).

    In plain wordsIn mice, Epitalon lowered the rate of chromosome damage in bone marrow cells compared with saline.

    Peptide
    Epitalon
    Outcome
    DecreaseFrequency of chromosome aberrations in bone marrow cells
    Study

    Mouse (female Swiss-derived SHR)n: not reported in source

    Comparator
    Saline control
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    1.0 µg/mouse · subcutaneous · From 3 months of age until natural death, 5 consecutive days every monthAs given in this study (Mouse (female Swiss-derived SHR)).

    Measurements

    Decrease in chromosome aberration frequency
    17.1%
    Epitalon vs control

    Source sentences

    Summary
    decreased the frequency of chromosome aberrations in bone marrow cells (by 17.1%, P<0.05).
    1 context sentence
    Summary · context
    From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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