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Study · Not a test of the peptide alone · 2003

3 results

PEGylation of growth hormone-releasing hormone (GRF) analogues.

Esposito P, Barbero L, Caccia P, Caliceti P, D'Antonio M, Piquet G, Veronese FM

Advanced drug delivery reviews1 Sept 2003Cited by 55 (Europe PMC)

PMID14499707 (opens in a new tab)DOI10.1016/s0169-409x(03)00109-1 (opens in a new tab)PepBankPUB-14499707
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Sermorelin.

  1. 01AnimalNot a test of Sermorelin aloneAnimal study (in vivo)Activity measurement

    Mono-PEGylated GRF isomers with PEG5000 at Lys 12 or Lys 21 gave a higher pharmacodynamic response than unmodified GRF.

    In plain wordsIn animal tests, GRF with one PEG chain attached gave a stronger hormone response than unmodified GRF.

    Peptide
    Sermorelin
    Outcome
    IncreasePharmacodynamic response to mono-PEGylated GRF isomers
    Study

    rat, pign: not reported in source

    Comparator
    Unmodified GRF
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Mono-PEGylated isomers with a PEG5000 polymer chain linked to Lys 12 or Lys 21 residues, showed high biological activity in vitro, which is similar to that of hGRF1-29, and a higher pharmacodynamic response as compared to unmodified GRF molecule.
    1 context sentence
    Summary · context
    Different PEGylated GRF conjugates were obtained and their bioactivity was tested in vitro and in vivo by monitoring endogenous growth hormone (GH) serum levels after intravenous (i.v.) injection in rats, and intravenous and subcutaneous (s.c.) injection in pigs.

    In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.

  2. 02LabNot a test of Sermorelin aloneIn vitro (cells)Activity measurement

    PEGylated GRF conjugates bound and activated the human GRF receptor, with different potency between conjugates.

    In plain wordsIn lab tests, GRF peptides with PEG attached could bind and switch on the human GRF receptor, with varying strength.

    Peptide
    Sermorelin
    Outcome
    Not applicableGRF receptor binding and activation by GRF-PEG conjugates
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    It was found that GRF-PEG conjugates are able to bind and activate the human GRF receptor, although with different potency.
    1 context sentence
    Summary · context
    Different PEGylated GRF conjugates were obtained and their bioactivity was tested in vitro and in vivo by monitoring endogenous growth hormone (GH) serum levels after intravenous (i.v.) injection in rats, and intravenous and subcutaneous (s.c.) injection in pigs.

    In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.

  3. 03LabNot a test of Sermorelin aloneIn vitro (cells)Activity measurement

    Mono-PEGylated GRF isomers with PEG5000 at Lys 12 or Lys 21 had in vitro biological activity similar to hGRF1-29.

    In plain wordsIn lab tests, GRF with one PEG chain attached worked about as strongly as unmodified hGRF1-29.

    Peptide
    Sermorelin
    Outcome
    No significant changeIn vitro bioactivity of mono-PEGylated GRF isomers
    Study

    n: not reported in source

    Comparator
    hGRF1-29
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Mono-PEGylated isomers with a PEG5000 polymer chain linked to Lys 12 or Lys 21 residues, showed high biological activity in vitro, which is similar to that of hGRF1-29
    1 context sentence
    Summary · context
    Different PEGylated GRF conjugates were obtained and their bioactivity was tested in vitro and in vivo by monitoring endogenous growth hormone (GH) serum levels after intravenous (i.v.) injection in rats, and intravenous and subcutaneous (s.c.) injection in pigs.

    In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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