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Study · In vitro (cells) · rat · 2003

4 results

Thymosin alpha-1 modulates excitatory synaptic transmission in cultured hippocampal neurons in rats.

Yang S, Liu ZW, Zhou WX, Zhang YX

Neuroscience letters1 Oct 2003Cited by 11 (Europe PMC)

PMID12972158 (opens in a new tab)DOI10.1016/s0304-3940(03)00862-0 (opens in a new tab)PepBankPUB-12972158
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cultured rat hippocampal neurons, acute thymosin alpha‑1 at 1 and 10 µg/ml increased the frequency of AMPA-mediated spontaneous excitatory postsynaptic currents.

    In plain wordsIn rat brain cells in a dish, thymosin alpha‑1 made spontaneous excitatory signals occur more often.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasesEPSC frequency (AMPA-mediated)
    Study

    ratn: not reported in source

    cultured hippocampal neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 and 10 µg/ml · acuteAs given in this study (rat).

    Measurements

    concentration
    1 to 10 microg/ml
    sEPSC frequency

    Source sentences

    Summary
    acute treatment with Talpha1 significantly enhanced the frequency of AMPA-mediated spontaneous excitatory postsynaptic current (sEPSC) at the concentrations of 1 and 10 microg/ml
    1 context sentence
    Summary · context
    To further elucidate the role of Talpha1 in the CNS, the whole-cell recording technique was used to observe the effect of Talpha1 on the spontaneous excitatory synaptic transmission in cultured rat hippocampal neurons.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured rat hippocampal neurons, acute thymosin alpha‑1 at 10 µg/ml increased the frequency of AMPA-mediated miniature excitatory postsynaptic currents.

    In plain wordsIn rat brain cells in a dish, thymosin alpha‑1 made miniature excitatory signals occur more often at the higher concentration.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasemEPSC frequency (AMPA-mediated)
    Study

    ratn: not reported in source

    cultured hippocampal neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 µg/ml · acuteAs given in this study (rat).

    Measurements

    concentration
    10 microg/ml
    mEPSC frequency

    Source sentences

    Summary
    also enhanced the frequency of AMPA-mediated miniature excitatory postsynaptic current (mEPSC) at 10 microg/ml.
    1 context sentence
    Summary · context
    To further elucidate the role of Talpha1 in the CNS, the whole-cell recording technique was used to observe the effect of Talpha1 on the spontaneous excitatory synaptic transmission in cultured rat hippocampal neurons.
  3. 03LabIn vitro (cells)Activity measurement

    In cultured rat hippocampal neurons, thymosin alpha‑1 did not change the amplitude of spontaneous excitatory postsynaptic currents.

    In plain wordsIn rat brain cells in a dish, thymosin alpha‑1 did not change the size of spontaneous signals.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changesEPSC amplitude
    Study

    ratn: not reported in source

    cultured hippocampal neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · acuteAs given in this study (rat).

    Source sentences

    Summary
    However, the amplitude of both sEPSC and mEPSC were not changed by Talpha1.
    1 context sentence
    Summary · context
    To further elucidate the role of Talpha1 in the CNS, the whole-cell recording technique was used to observe the effect of Talpha1 on the spontaneous excitatory synaptic transmission in cultured rat hippocampal neurons.
  4. 04LabIn vitro (cells)Activity measurement

    In cultured rat hippocampal neurons, thymosin alpha‑1 did not change the amplitude of miniature excitatory postsynaptic currents.

    In plain wordsIn rat brain cells in a dish, thymosin alpha‑1 did not change the size of miniature signals.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changemEPSC amplitude
    Study

    ratn: not reported in source

    cultured hippocampal neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · acuteAs given in this study (rat).

    Source sentences

    Summary
    However, the amplitude of both sEPSC and mEPSC were not changed by Talpha1.
    1 context sentence
    Summary · context
    To further elucidate the role of Talpha1 in the CNS, the whole-cell recording technique was used to observe the effect of Talpha1 on the spontaneous excitatory synaptic transmission in cultured rat hippocampal neurons.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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